In vitro inhibitory effects on α-glucosidase and α-amylase level and antioxidant potential of seeds of Phoenix dactylifera L.

Khan, Shah Alam; Kiyumi, Amira Rashid Al; Sheidi, Manal Saif Al; Khusaibi, Tagreed Salim Al; Shehhi, Noura Mohammed Al; Alam, Tanveer

doi:10.1016/j.apjtb.2015.11.008

Cited by 56 publications

(38 citation statements)

References 23 publications

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“…Indeed, the fenugreek seeds [34], Marrubium vulgare [35], N. sativa [36], A. sativum [37], Carum carvi, and Ziziphus lotus [38,39] shows an antidiabetic effects in streptozotocininduced diabetic in rat and alloxan-induced diabetes in mice. Khan et al demonstrated in vitro that P. dactylifera seeds extract inhibit α-glucosidase and α-amylase level [40]. Our results revealed some MP with antidiabetic effects to be cited for the first time in southeastern of morocco, namely, C. cinerea L.,…”

Section: Discussionmentioning

confidence: 62%

Ethnopharmacological survey of medicinal plants with hallucinogenic effect and plants used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora Morocco.

Boufous¹,

Marhoume²,

Chait³

et al. 2017

J Intercult Ethnopharmacol

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Aim:The aim of this study was to identify different plants used in folk medicine for treating pain, inflammatory diseases, diabetes and kidney stones by the population of Zagora province, in Southeastern of Morocco. This investigation was undertaken during more than 2 years started in 2013 and ended in 2015. Materials and Methods: A total of 1400 person with different ages between 20 and 80 years, in 12 areas, was included in this survey; 348 were diabetics, 292 were suffering from kidney stones and 760 healthy. Data collected was separated in two parts. The first part concerned interviewee information's (age, sex, and level of education) and the second part was designed for plants uses (vernacular names, uses, parts used, and mode of preparation). Use value (UV), fidelity level and family UV (FUV) were calculated. Results: We inventoried 83 plants species belonging to 40 families that were used. Ranunculaceae family showed the highest significance (FUV = 0.36). Six species with the highest UV were Zygophyllum gaetulum L. We identified 50 species used for treating or managing pain, 45 for diabetes, 19 for kidney stone, 7 for treating inflammatory diseases, and only 3 species that were recognized with hallucinogenic effects. Conclusions: This study shows that folk medicine in Zagora still occupies a high level in primary health care. Data collected may help to preserve knowledge about different plants used and their mode of preparation.

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Section: Discussionmentioning

confidence: 62%

Ethnopharmacological survey of medicinal plants with hallucinogenic effect and plants used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora Morocco.

Boufous¹,

Marhoume²,

Chait³

et al. 2017

J Intercult Ethnopharmacol

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“…Regarding the medical uses, the date fruits are extensively studied and they are claimed to have anti-tumor agents, anti-inflammatory, anti-microbial, anti-oxidant, nephro-protective, hepato-protective, anti-diabetic and sex hormone modulator [10]. Although, the seeds of dates are less explored in biomedical research, they were found to have an antioxidant and anti-diabetic activity [11]. Investigations on leaves of date palm are scant, it was reported that they have anti-diabetic activity [12].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity and antioxidant potential of the methanolic leaf extracts of three cultivars of date palm trees (Phoenix dactylifera) from Saudi Arabia

Abdallah¹,

Musa²,

Qureshi³

et al. 2017

Med-Science

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The date palm tree (Phoenix dactylifera) is one of the oldest cultivated plants ever known; it is considered the life tree for Arabs. However, there is no adequate information about the bioactivity of the leaves. In this study, the methanol extract of leaves demonstrated the presence of some compounds with potential biomedical properties for human, such as cardiac steroids, flavonoids, phenols/polyphenols, phytosterols, quinines, saponins, tannins and resin. The results of the antimicrobial test indicate that the methanol leaf extracts of the three date palm cultivars contained potential antibacterial agents, particularly against Gram-positive bacteria and no antifungal effect can be detected on Candida albicans. The most susceptible bacteria were Staphylococcus aureus, Staphylococcus epidermidis, Bacillus cereus and Enterococcus faecalis, respectively. The antioxidant activities of methanol extracts of different leaf cultivars were also investigated, using DPPH (2, 2-diphenyl-2-picrymhydrasyl hydrate) radical-scavenging activity assay, all extracts showed considerable antioxidant potential. The current investigation suggests that leaves of date palm can be used as a promising source of natural antibacterial and antioxidant drugs.

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“…It is known as an antidiabetic drug. As a result, these inhibitors help to prevent the breakdown of sugars and also control the postprandial blood glucose levels . The herbal drug is first‐line of treatment of hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

Exploring the antidiabetic and anti‐obesity properties of Samanea saman through in vitro and in vivo approaches

Vinodhini

Rajeswari

2018

J of Cellular Biochemistry

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In recent years, diabetes and obesity have become a major problem in global health care because of changes in lifestyle, food habits, and age‐related metabolic disorders. Diabetes mellitus is one of the most common diseases, affecting millions of people worldwide. Currently, herbal drugs are used to control obesity and diabetes. The present study investigates the anti‐obesity, antidiabetic, and antioxidant activities of Samanea saman leaf extract. A methanolic extract of S. saman leaves was prepared by a maceration method. The S. saman leaf extract was studied for its inhibitory effect on glucose utilization using specific in vitro procedures to analyze its antioxidant, anti‐obesity, and antidiabetic activities via different assays, such as α‐amylase and α‐glucosidase inhibition assay, glucose uptake by yeast cells, nonenzymatic glycosylation assay followed by glucose diffusion assay. The outcome of the study showed that the methanolic extract strongly inhibited the pancreatic lipase, α‐amylase, and glucosidase activities, compared with the standard drug. The results showed that the extract possessed considerable antioxidant and antidiabetic activities, and further studies are needed to confirm the results using an in vivo model. Thus, it is proposed that S. saman can be used as a therapeutic agent.

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In vitro inhibitory effects on α-glucosidase and α-amylase level and antioxidant potential of seeds of Phoenix dactylifera L.

Cited by 56 publications

References 23 publications

Ethnopharmacological survey of medicinal plants with hallucinogenic effect and plants used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora Morocco.

Ethnopharmacological survey of medicinal plants with hallucinogenic effect and plants used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora Morocco.

Antimicrobial activity and antioxidant potential of the methanolic leaf extracts of three cultivars of date palm trees (Phoenix dactylifera) from Saudi Arabia

Exploring the antidiabetic and anti‐obesity properties of Samanea saman through in vitro and in vivo approaches

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In vitro inhibitory effects on α-glucosidase and α-amylase level and antioxidant potential of seeds of Phoenix dactylifera L.

Cited by 56 publications

References 23 publications

Ethnopharmacological survey of medicinal plants with hallucinogenic effect and plants used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora Morocco.

Ethnopharmacological survey of medicinal plants with hallucinogenic effect and plants used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora Morocco.

Antimicrobial activity and antioxidant potential of the methanolic leaf extracts of three cultivars of date palm trees (Phoenix dactylifera) from Saudi Arabia

Exploring the antidiabetic and anti‐obesity properties of Samanea saman through in vitro and in vivo approaches

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Product

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Ethnopharmacological survey of medicinal plants with hallucinogenic effect and plants used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora Morocco.

Ethnopharmacological survey of medicinal plants with hallucinogenic effect and plants used against pain, inflammatory diseases, diabetes and urinary lithiasis in Zagora Morocco.