In vitro Intervention of Lactobacillus paracasei N1115 Can Alter Fecal Microbiota and Their SCFAs Metabolism of Pregnant Women with Constipation and Diarrhea

Dang, Chongshu; Zhao, Kexin; Xun, Yiping; Li, Feng; Zhang, Dong; Cui, Liru; Cui, Yue; Jia, Xianxian; Wang, Shijie

doi:10.1007/s00284-022-02906-5

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…In the present study, we found that WECSL treatment significantly decreased the abundance of Prevotellaceae, Bacteroidaceae, Erysipelotrichaceae, a n d Desulfovibrionaceae but increased the abundance of Lachnospiraceae, Ruminococcaceae, Lactobacillaceae, and Spirochaetaceae in constipated mice. Besides the beneficial effect of Lactobacillus from Lactobacillaceae in patients with constipation, studies have also confirmed that intervention of Lactobacillus can improve intestinal mobility in pregnancy, thus improving quality of life (Liu et al, 2021;Dang et al, 2022). Both LDA and LEfSe analyses revealed that the abundance of Ruminococcaceae was significantly enriched after WECSL treatment.…”

Section: Discussionmentioning

confidence: 95%

“…Studies using a dextran sulfate sodium-induced colitis mouse model showed that Parasutterella was a harmful bacterium and that diet modification (Li et al, 2022) or crocetin (Dang et al, 2022) could decrease the abundance of Parasutterella. Maternal intake of inulin can aggravate intestinal damage and inflammation in the offspring of rats with colitis through regulating the intestinal microbiota, Frontiers in Pharmacology frontiersin.org including increasing the abundance of Parasutterella.…”

Section: Discussionmentioning

confidence: 99%

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Cannabis sativa L. alleviates loperamide-induced constipation by modulating the composition of gut microbiota in mice

et al. 2022

Front. Pharmacol.

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MaZiRenWan (MZRW) is the most frequently used Traditional Chinese Medicine formula to treat chronic constipation, Cannabis sativa L. is regarded as a monarch drug in MZRW. However, the targets of Cannabis sativa L. that enhance colonic motility and improve constipation symptoms remain unknown. This study was designed to investigate the laxative effect and underlying mechanism of the water extract of Cannabis sativa L. (WECSL) using a loperamide-induced constipation mouse model. We found that WECSL treatment significantly improved intestinal motility and water-electrolyte metabolism, decreased inflammatory responses, prevented gut barrier damage, and relieved anxiety and depression in constipated mice. WECSL also structurally remodeled the composition of the gut microbiota and altered the abundance of bacteria related to inflammation, specifically Butyricicoccus and Parasutterella. Moreover, WECSL failed to relieve constipation symptoms following intestinal flora depletion, indicating that WECSL alleviates constipation symptoms depending on the gut microbiota. Our research provides a basis for WECSL to be further investigated in the treatment of constipation from the perspective of modern medicine.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Cannabis sativa L. alleviates loperamide-induced constipation by modulating the composition of gut microbiota in mice

et al. 2022

Front. Pharmacol.

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“…Lactobacillus paracasei N1115 (Lp N1115) was isolated from fermented milk products that have long been consumed by herders in Mongolia [24] and has potential probiotic properties such as the ability to promote intestinal development [25], improve intestinal symptoms [26], and regulate immunity [27]. However, the current research on Lp N1115 is mostly conducted on animals or in adults, and fewer trials are conducted on infants and young children.…”

Section: Introductionmentioning

confidence: 99%

Effect of Lacticaseibacillus paracasei N1115 on Immunomodulatory and Gut Microbial Composition in Young Children: A Randomized, Placebo-Controlled Study

Ren

Zhou

et al. 2023

Nutrients

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Lactobacillus paracasei N1115 (Lp N1115) was isolated from fermented milk products. The administration of Lp N1115 is safe and well tolerated in Chinese children, but its effectiveness among young Chinese children is still unclear. To investigate the efficacy of Lp N1115 as a probiotic to enhance gut development in Chinese infants and toddlers born by cesarean section, 109 healthy and cesarean-delivered infants aged 6–24 months were recruited for a 12-week randomized, placebo-controlled trial, with 101 finally completing the study. Saliva and stool samples were collected and detected at weeks 0, 4, 8, and 12 of the intervention. Statistical analyses were performed by using a per-protocol (PP) approach. After 12 weeks of intervention, the fecal pH in the control group increased (p = 0.003), while the fecal pH in the experimental group did not change. Salivary cortisol decreased from baseline in the experimental group (p = 0.023), while the control group showed little change. In addition, Lp N1115 increased the fecal sIgA content of infants aged 6–12 months (p = 0.044) but had no obvious effect on fecal calprotectin and saliva sIgA. At week 4, the increase in Lactobacillus relative to baseline was higher in the experimental group than in the control group (p = 0.019). Further analysis showed a trend toward a higher detection rate of Lactobacillus in the experimental group than in the control group (p = 0.039). In conclusion, Lp N1115 was able to enhance the content of Lactobacillus and maintain fecal pH levels. Its beneficial effects on gut development were more obvious in 6–12-month-old infants.

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Probiotic treatment induces changes in intestinal microbiota but does not alter SCFA levels in peritoneal dialysis patients—a randomized, placebo-controlled trial

Zhou,

Yan,

Chu

et al. 2024

Sci Rep

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In vitro Intervention of Lactobacillus paracasei N1115 Can Alter Fecal Microbiota and Their SCFAs Metabolism of Pregnant Women with Constipation and Diarrhea

Cited by 5 publications

References 49 publications

Cannabis sativa L. alleviates loperamide-induced constipation by modulating the composition of gut microbiota in mice

Cannabis sativa L. alleviates loperamide-induced constipation by modulating the composition of gut microbiota in mice

Effect of Lacticaseibacillus paracasei N1115 on Immunomodulatory and Gut Microbial Composition in Young Children: A Randomized, Placebo-Controlled Study

Probiotic treatment induces changes in intestinal microbiota but does not alter SCFA levels in peritoneal dialysis patients—a randomized, placebo-controlled trial

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