In vitro Investigation of Antioxidant Phenolic Compounds in Extracts of Senna alata

Okpuzor, Joy; Ogbunugafor, H. A.; Kareem, G. K.; Igwo-Ezikpe, Miriam

doi:10.3923/rjphyto.2009.68.76

Cited by 42 publications

(28 citation statements)

References 12 publications

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“…Phenolics possess a wide spectrum of biochemical activities such as antioxidant, antimutagenic, anticarcinogenic as well as ability to modify the gene expression[2]. Phenolics are the largest group of phytochemicals that account for most of the antioxidant activity in plants or plant products[3]. …”

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confidence: 99%

Total phenolics and total flavonoids in selected Indian medicinal plants

Sulaiman¹,

Balachandran²

2012

Indian J Pharm Sci

172

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Plant phenolics and flavonoids have a powerful biological activity, which outlines the necessity of their determination. The phenolics and flavonoids content of 20 medicinal plants were determined in the present investigation. The phenolic content was determined by using Folin-Ciocalteu assay. The total flavonoids were measured spectrophotometrically by using the aluminium chloride colorimetric assay. The results showed that the family Mimosaceae is the richest source of phenolics, (Acacia nilotica: 80.63 mg gallic acid equivalents, Acacia catechu 78.12 mg gallic acid equivalents, Albizia lebbeck 66.23 mg gallic acid equivalents). The highest total flavonoid content was revealed in Senna tora which belongs to the family Caesalpiniaceae. The present study also shows the ratio of flavonoids to the phenolics in each sample for their specificity.

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confidence: 99%

Total phenolics and total flavonoids in selected Indian medicinal plants

Sulaiman¹,

Balachandran²

2012

Indian J Pharm Sci

172

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“…Phenolic compounds, including flavonoids, are considered the largest group of phytochemicals that account for most of the antioxidant activity of plants and plant products [46] . They are particularly beneficial, acting as antioxidant due to their polyphenolic nature, which enables them to donate electrons [47] and scavenge injurious free radicals [48] .…”

Section: Table 1: Antioxidant Activities and Total Phenolic Flavonoimentioning

confidence: 99%

Evaluation of Antioxidant Capacity and Identification of Bioactive Compounds of Crude Methanol Extracts of Caesalpinia pulcherrima (L.) Swartz

Torre¹

2017

ijps

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PhilippinesDela Torre, et al.: Antioxidant Capacity of C. pulcherrimaThe study was conducted to determine the antioxidant capacity, expressed as half maximal inhibitory concentration, IC 50 , of Caesalpinia pulcherrima leaf, flower and seed methanol extracts, and their correlation to their total phenolic, flavonoid and triterpenoid contents. Thin layer chromatographic profiling of the methanol extracts was also conducted followed by ultra-performance liquid chromatography quadruple time-of-flight mass spectrometric analysis for the identification of antioxidant compounds. Based on the quantitative antioxidant assays, all extracts exhibited comparable activity with the reference standard at 800 µg/ml (P>0.05). Correlation data revealed a strong negative correlation between the IC 50 and the total phenolic, flavonoid and triterpenoid contents of the extracts, with statistically significant negative correlations observed between the flavonoids of leaf (r=−0.997) and flower (r=−0.998) with reducing power assay, and triterpenoids of flower (r=−1.000) with 2,2-diphenyl-1-picrylhydrazyl scavenging assay. Two common spots with antioxidant activity in the thin layer chromatography profiles were subjected to ultra-performance liquid chromatography quadruple time-of-flight mass spectrometric. The majority of compounds were identified in the library as triterpenoids, flavonoids and phenolics, and still a large quantity of compounds were unidentified. Hyperforin, 3-(4'-hydroxy-benzyl)-5,7-dihydroxy-6,8-dimethyl-chroman-4-one and platycodigenin were identified to be the common compounds present on the three plant parts.

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“…The extract demonstrated signifi cant antioxidant and radical scavenging activities, namely, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and hydroxyl radical scavenging activities, high lipid peroxidation inhibitory activity but low nitric oxide radical scavenging activity. The ethyl acetate extract of S. alata aerial parts was found to possess antioxidant properties as expressed by increase in antioxidant enzymes and the presence of phenolic compounds fl avonoids naringin and apigenin (Okpuzor et al 2009 ).…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Cassia alata extract is used in traditional medicine practice for the treatment of some external skin infections in Nigeria, the juice expressed from the young leaves being applied topically to the skin (Benjamin and Lamikanra 1981 ; Alalor et al 2012 ). Senna alata is widely used in ethnomedicine practice for the treatment of hypertension, sickle cell anaemia and diabetes in southwestern Nigeria (Okpuzor et al 2009 ). Saye, a combination remedy prepared from Cochlospermum planchonii, Cassia alata and Phyllanthus amarus ; N'Dribala, a Cochlospermum planchonii root decoction; and a fruit preparation of Azadirachta indica are plant remedies of the folk medicine in Burkina Faso and are commonly used by traditional healers for the treatment of malaria (Yerbanga et al 2012 ) Leaves are commonly employed for constipation in Nigeria and other African countries.…”

Section: Traditional Medicinal Usesmentioning

confidence: 99%

Senna alata

Lim¹

2013

Edible Medicinal and Non-Medicinal Plants

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In vitro Investigation of Antioxidant Phenolic Compounds in Extracts of Senna alata

Cited by 42 publications

References 12 publications

Total phenolics and total flavonoids in selected Indian medicinal plants

Total phenolics and total flavonoids in selected Indian medicinal plants

Evaluation of Antioxidant Capacity and Identification of Bioactive Compounds of Crude Methanol Extracts of Caesalpinia pulcherrima (L.) Swartz

Senna alata

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