In vitro lymphocyte proliferation induced by radio‐frequency electromagnetic radiation under isothermal conditions

Cleary, Stephen F.; Liu, Liming; Merchant, Randall E.

doi:10.1002/bem.2250110107

Cited by 49 publications

(19 citation statements)

References 13 publications

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“…Studies on the effects of microwave exposure conducted by the Rochester Group and by Cleary et al [1990] can not be readily compared. The experiment conducted by the Rochester Group consisted in exposure of human lymphocytes for 2 h before stimulation with PHA, subsequent addition of PHA and evaluation of the preparations extended by determination of thymidine incorporation.…”

Section: Resultsmentioning

confidence: 97%

Effects of continuous and pulsed 2450‐MHz radiation on spontaneous lymphoblastoid transformation of human lymphocytes in vitro

Czerska

Elson

Davis

et al. 1992

Bioelectromagnetics

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Normal human lymphocytes were isolated from the peripheral blood of healthy donors. One-ml samples containing (10(6)) cells in chromosome medium 1A were exposed for 5 days to conventional heating or to continuous wave (CW) or pulsed wave (PW) 2450-MHz radiation at non-heating (37 degrees C) and various heating levels (temperature increases of 0.5, 1.0, 1.5, and 2 degrees C). The pulsed exposures involved 1-microsecond pulses at pulse repetition frequencies from 100 to 1,000 pulses per second at the same average SAR levels as the CW exposures. Actual average SARs ranged to 12.3 W/kg. Following termination of the incubation period, spontaneous lymphoblastoid transformation was determined with an image analysis system. The results were compared among each of the experimental conditions and with sham-exposed cultures. At non-heating levels, CW exposure did not affect transformation. At heating levels both conventional and CW heating enhanced transformation to the same extent and correlate with the increases in incubation temperature. PW exposure enhanced transformation at non-heating levels. This finding is significant (P less than .002). At heating levels PW exposure enhanced transformation to a greater extent than did conventional or CW heating. This finding is significant at the .02 level. We conclude that PW 2450-MHz radiation acts differently on the process of lymphoblastoid transformation in vitro compared with CW 2450-MHz radiation at the same average SARs.

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Section: Resultsmentioning

confidence: 97%

Effects of continuous and pulsed 2450‐MHz radiation on spontaneous lymphoblastoid transformation of human lymphocytes in vitro

Czerska

Elson

Davis

et al. 1992

Bioelectromagnetics

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“…Notice that previous investigations of effects of low-intensive microwave radiation also show the immunomodulating effects at certain frequency ranges and intensities (see, e.g. [9,26]). These findings stimulate our interest to study the influence of weak centimetre electromagnetic waves on tumour-immune dynamics.…”

Section: Introductionmentioning

confidence: 94%

Modelling of Anti‐Tumour Immune Response: Immunocorrective Effect of Weak Centimetre Electromagnetic Waves

Isaeva

Osipov

2008

Computational and Mathematical Methods in Medicine

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We formulate the dynamical model for the anti-tumour immune response based on intercellular cytokine-mediated interactions with the interleukin-2 (IL-2) taken into account. The analysis shows that the expression level of tumour antigens on antigen presenting cells has a distinct influence on the tumour dynamics. At low antigen presentation, a progressive tumour growth takes place to the highest possible value. At high antigen presentation, there is a decrease in tumour size to some value when the dynamical equilibrium between the tumour and the immune system is reached. In the case of the medium antigen presentation, both these regimes can be realized depending on the initial tumour size and the condition of the immune system. A pronounced immunomodulating effect (the suppression of tumour growth and the normalization of IL-2 concentration) is established by considering the influence of low-intensity electromagnetic microwaves as a parametric perturbation of the dynamical system. This finding is in qualitative agreement with the recent experimental results on immunocorrective effects of centimetre electromagnetic waves in tumour-bearing mice.

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“…Athermal effects on gross transcription, as measured by incorporation of the specific RNA precursor 3H-uridine, have been reported following the exposure of glioma cells to CW RF and microwave radiation (31). Similar effects on cellular proliferation, assayed as the incorporation of the specific DNA precursor 3H-thymidine, were also reported following exposure of human lymphocytes (32) or glioma cells (31). Both transcription and proliferation were elevated at an SAR of 25 (34).…”

Section: Promotion and Progression Studiesmentioning

confidence: 80%

Radiofrequency field exposure and cancer: what do the laboratory studies suggest?

Repacholi

1997

Environ Health Perspect

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Significant concern has been raised about possible health effects from exposure to radiofrequency (RF) electromagnetic fields, especially after the rapid introduction of mobile telecommunications systems. Parents are especially concerned with the possibility that children might develop cancer after exposure to the RF emissions from mobile telephone base stations erected in or near schools. These questions have followed scientific reports suggesting that residence near high voltage power lines may to be associated with an increased childhood leukemia risk. Epidemiologic studies have been plagued by poor RF exposure assessment and differences in methodology. There are no high-quality epidemiologic studies that can be used to evaluate health risks from RF exposure. Laboratory studies in this area have been somewhat confusing. Some animal studies suggest that RF fields accelerate the development of sarcoma colonies in the lung, mammary tumors, skin tumors, hepatomas, and sarcomas. A substantial RF-induced increase in lymphoma incidence in transgenic mice exposed for up to 18 months has also been reported. In contrast, other studies have not found carcinogenic effects. These conflicting results indicate the need for more well-conducted studies on laboratory animals, supplemented with high-quality in vitro studies to identify effects that need further research in vivo, and to characterize any acting mechanisms, especially at low RF field levels. This paper provides a review of the laboratory studies and indicates what conclusions about RF-induced cancer can be drawn. Environ Health Perspect 1 05(Suppl 6): 1565-1568 (1997)

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In vitro lymphocyte proliferation induced by radio‐frequency electromagnetic radiation under isothermal conditions

Cited by 49 publications

References 13 publications

Effects of continuous and pulsed 2450‐MHz radiation on spontaneous lymphoblastoid transformation of human lymphocytes in vitro

Effects of continuous and pulsed 2450‐MHz radiation on spontaneous lymphoblastoid transformation of human lymphocytes in vitro

Modelling of Anti‐Tumour Immune Response: Immunocorrective Effect of Weak Centimetre Electromagnetic Waves

Radiofrequency field exposure and cancer: what do the laboratory studies suggest?

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