In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars

Renò, Filippo; Sabbatini, Maurizio; Lombardi, Francesca; Stella, Maurizio; Pezzuto, Carla; Magliacani, G.; Cannas, M.

doi:10.1046/j.1524-475x.2003.11504.x

Cited by 115 publications

(76 citation statements)

References 39 publications

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“…is less unlikely, but the absence of any specific clue, together with the rarity of the rash and the impossibility to perform epicutaneous testing, works against this hypothesis. A plausible explanation may be that a circulating factor would home into (or be already present in) the skin and elicit an inflammatory response, which may be turned off in areas prone to external pressure, as already demonstrated in other skin conditions [110,111]. …”

Section: Discussionmentioning

confidence: 99%

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Torchia

Miteva

et al. 2010

Dermatology

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Background: Even after the description of papuloerythroderma of Ofuji (PEO) in 1984, little is known about this clinical entity. Objective:To report on 2 new cases of PEO and review of the worldwide literature on this topic. Methods: Article citations were searched on several biomedical search engines (PubMed, EMBASE, SCOPUS, Google Scholar). Papers were retrieved either online or in print. Results: A grand total of 170 PEO cases were identified. Most patients were older than 55 years and of Asian or white descent, with an overall male/female ratio of 4.0. Itch and the deck-chair sign were observed in all patients. Peripheral eosinophilia, lymphocytopenia and increased serum IgE were common findings. Histopathology mostly showed aspecific inflammation, while 17 showed histological features of cutaneous T-cell lymphoma (CTCL). Atopy, malignancies, infections and drugs were rarely linked to PEO. Conclusion: PEO represents a rather monomorphous entity both clinically and, with the remarkable exception of CTCL, also histologically. Nonetheless, no causative factor could be identified in the vast majority of cases. An etiological classification and diagnostic criteria are proposed in the attempt to contribute framing this puzzling clinical entity.

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Section: Discussionmentioning

confidence: 99%

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Torchia

Miteva

et al. 2010

Dermatology

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“…Currently, pressure garments are predominantly used for the prophylaxis of hypertrophic burn scar formation, despite controversial data regarding their value in reducing excessive scarring and little scientific evidence supporting their use (5). The mechanism of action of pressure therapy remains poorly understood; however, possible mechanisms are decreased collagen synthesis attributable to limiting of the supply of blood, oxygen and nutrients to the scar tissue (86)(87)(88) and increased apoptosis (89).…”

Section: Prophylaxismentioning

confidence: 99%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,178

1,012

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Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies.

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“…Compression therapy reduces tension around the wound. It has been found to decrease in the burden of hypertrophic scarring in 60-85% of patients [34]. In vitro, compression of hypertrophic scars has been found to induce apoptosis of fibroblasts [34].…”

Section: Current and Future Therapymentioning

confidence: 99%

Pathophysiology of post-operative scars

Qureshi

Orgill

2012

Eur Surg

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Background: Major surgical procedures result in varying degrees of scar as a visible endpoint of wound healing. Efforts to minimize post-operative scar formation that can lead to painful or unsightly scars have been motivated by the unpredictability and potential for abnormal scarring. The formation of scars following surgery is of particular interest to plastic surgeons. We review here the classic stages of wound repair and the mechanical forces that affect post-operative scarring.Methods: The peer-reviewed literature within the last 10 years was studied using an evidence-based approach.Results: Pre-clinical and clinical studies suggest that post-operative scar formation begins with the surgical incision and is influenced by the local wound environment as it passes through the classic stages of inflammation, proliferation and remodeling. Mechanical forces including tension, depth and epidermal closure all influence scarring as demonstrated in animal models and clinical experience. Dermal regeneration templates have both scar reductive and regenerative properties. Current scar therapy includes compression therapy, silicone gel sheeting, radiation therapy and molecular therapy albeit with variable success.Conclusions: Post-operative scar forms as the result of a highly conserved cascade of events following surgery that seeks to restore skin integrity and is influenced by the wound environment's physical properties likely through cellular mechanotransduction. While current therapies seek to minimize scar formation based on our understanding of these forces, further research on the molecular and mechanical forces affecting post-operative scarring will allow for clinical applications to minimization scar formation.

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In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars

Cited by 115 publications

References 39 publications

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Pathophysiology of post-operative scars

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