In Vitro Metabolism of Palmitic Acid in Human Fetal Tissue

Yoshioka, Tamotsu; Roux, J

doi:10.1203/00006450-197208000-00005

Cited by 40 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are compatible with earlier investigations that demonstrated the presence of carnitine acyltransferase and carnitine palmitoyltransferase activities in the human placenta (1 2-14), as well as the capacity of human placental tissue to oxidize I4C-palmitate in vitro (35), and of placental mitochondria to oxidize palmitoylcarnitine (36).…”

Section: Discussionsupporting

confidence: 82%

Transfer and Metabolism of Carnitine and Carnitine Esters in the in Vitro Perfused Human Placenta

et al. 1985

View full text Add to dashboard Cite

ABSTRAa. The transfer and metabolism of L-carnitine, L-acetylcarnitine, and L-palmitoylcarnitine were studied in the human placenta at term by means of in vitro dual perfusion of a placental lobe. L-Carnitine transfer was 20% that of the freely diffusing antipyrine and 40% that of Llysine. The transfer of L-acetylcarnitine was similar to that of ccarnitine, but no placental transfer of L-palmitoylcarnitine was found. In contrast to L-lvsine. L-carnitine. and -,

show abstract

Section: Discussionsupporting

confidence: 82%

Transfer and Metabolism of Carnitine and Carnitine Esters in the in Vitro Perfused Human Placenta

et al. 1985

View full text Add to dashboard Cite

show abstract

“…There was relatively little combustion to CO 2 (about 1%), a result similar to those obtained by others [16]. Since these studies have been done, a more extensive study of the metabolism of palmitic acid by human placental and fetal tissues has appeared [23].…”

Section: Resultssupporting

confidence: 69%

Transfer Across Perfused Human Placenta. II. Free Fatty Acids

et al. 1973

View full text Add to dashboard Cite

“…At all time intervals studied, the percentage of total radioactivity in phos pholipids was always greater than that in the triglycerides. This is in contrast to the results of Yoshioka and Roux (1972) who found that in term human placentas the majority of the incorporated label was in the FFA fraction even after 2 h incubation. However, in both species, appreciable amounts of label from 1-[14C]-palmitate are esterified into phospholipids.…”

Section: Discussioncontrasting

confidence: 56%

“…In studies of fetal brain, liver, lung and the placen ta it was found that the rate of oxidation of fatty acids was low (Yoshioka and Roux, 1972;Roux and Myers, 1974). However, it is known that there is an increased mobilization and oxidation of fatty acids after birth, as indicated by increases in plasma FFA and glycerol levels and a decrease in respiratory quotient.…”

Section: Introductionmentioning

confidence: 99%

Uptake and Metabolism of <sup>14</sup>C-Palmitate by Fetal Rabbit Tissues

Hudson¹,

Hull²

1977

Neonatology

View full text Add to dashboard Cite

The uptake and esterification of ¹⁴C-palmitate into lipid classes in placenta, fetal brown adipose tissue (BAT) and liver of rabbits were investigated in vitro. Fetal BAT showed a high rate of fatty acid uptake, 8.5 μmol·h^––¹ tissue·h^––1. From 5 min onwards, the majority of incorporated label was in the triglyceride fraction. The placenta and fetal liver also incorporated 1-[¹⁴C]-palmitate into both FFA and esterified lipid fractions, although at much lower rates than observed for BAT. In the liver, triglycerides, but in the placenta phospholipids, contained the majority of the label after 1 h incubation. BAT from both fetal and newborn rabbits released ¹⁴CO₂ and the production of ¹⁴CO₂ was greater in the presence of noradrenaline. The specific activity of the CO₂ was the same in stimulated and unstimulated tissue. It is concluded that BAT as well as the liver are important sites of free fatty acid removal from the fetal circulation. The potential for fatty acid oxidation is present in BAT of the 28-day rabbit fetus.

show abstract

In Vitro Metabolism of Palmitic Acid in Human Fetal Tissue

Cited by 40 publications

References 14 publications

Transfer and Metabolism of Carnitine and Carnitine Esters in the in Vitro Perfused Human Placenta

Transfer and Metabolism of Carnitine and Carnitine Esters in the in Vitro Perfused Human Placenta

Transfer Across Perfused Human Placenta. II. Free Fatty Acids

Uptake and Metabolism of <sup>14</sup>C-Palmitate by Fetal Rabbit Tissues

Contact Info

Product

Resources

About