Transfer Across Perfused Human Placenta. II. Free Fatty Acids

Dancis, Joseph; Jansen, Valerie; Kayden, Herbert J.; Schneider, H.; Levitz, Mortimer

doi:10.1203/00006450-197304000-00022

Cited by 102 publications

(44 citation statements)

References 16 publications

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“…The abundant intrauterine synthesis of Mead acid [19] is a consequence of the high de novo synthesis of OA from the ample glucose that crosses the placenta in the third trimester [20]. Together with other de novo synthesized fatty acids, OA constitutes about 80% of the fatty acids that accumulate in the newborn's fat mass [21]. The fetus synthesizes abundant OA, but receives limited fatty acids across the placenta [22] and is inefficient in trapping free linoleic acid (LA, 18:2n-6) as shown at least in primates [23].…”

Section: Discussionmentioning

confidence: 99%

Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio

Goor

Schaafsma

Erwich

et al. 2010

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio van Goor, S. A.; Schaafsma, A.; Erwich, Jan Jaap H. M.; Brouwer, Dineke; Muskiet, Frits Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. a b s t r a c tWe showed that docosahexaenoic acid (DHA) supplementation during pregnancy and lactation was associated with more mildly abnormal (MA) general movements (GMs) in the infants. Since this finding was unexpected and inter-individual DHA intakes are highly variable, we explored the relationship between GM quality and erythrocyte DHA, arachidonic acid (AA), DHA/AA and Mead acid in 57 infants of this trial. MA GMs were inversely related to AA, associated with Mead acid, and associated with DHA/ AA in a U-shaped manner. These relationships may indicate dependence of newborn AA status on synthesis from linoleic acid. This becomes restricted during the intrauterine period by abundant de novo synthesis of oleic and Mead acids from glucose, consistent with reduced insulin sensitivity during the third trimester. The descending part of the U-shaped relation between MA GMs and DHA/AA probably indicates DHA shortage next to AA shortage. The ascending part may reflect a different developmental trajectory that is not necessarily unfavorable.

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Section: Discussionmentioning

confidence: 99%

Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio

Goor

Schaafsma

Erwich

et al. 2010

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…We have recently postulated that the nucleoside, adenosine, may also be a candidate as an inhibitory neuromodulator (16,17). Our postulate is based on three lines of evidence: 1) theophylline, a specific competitive inhibitor of adenosine, is effective in treating neonatal apnea (1 8); 2) adenosine is rapidly released in the brain during hypoxia (1 9); and 3) adenosine depresses ventilation when administered systemically or applied to the brainstem (20).…”

Section: Discussionmentioning

confidence: 99%

Transfer and Metabolism of Carnitine and Carnitine Esters in the in Vitro Perfused Human Placenta

et al. 1985

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ABSTRAa. The transfer and metabolism of L-carnitine, L-acetylcarnitine, and L-palmitoylcarnitine were studied in the human placenta at term by means of in vitro dual perfusion of a placental lobe. L-Carnitine transfer was 20% that of the freely diffusing antipyrine and 40% that of Llysine. The transfer of L-acetylcarnitine was similar to that of ccarnitine, but no placental transfer of L-palmitoylcarnitine was found. In contrast to L-lvsine. L-carnitine. and -,

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“…Protein binding can affect transfer rates at three sites: by binding to albumin in the "maternal" perfusate, during transit through the placenta, and by binding to albumin in the "fetal" perfmate. The recent development of a technique for perfusing human placental in vitro (2) has made it possible to systemically investigate these possibilities.…”

Section: Speculationmentioning

confidence: 99%

Transfer across Perfused Human Placenta. IV. Effect of Protein Binding on Free Fatty Acids

1976

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Transfer Across Perfused Human Placenta. II. Free Fatty Acids

Cited by 102 publications

References 16 publications

Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio

Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio

Transfer and Metabolism of Carnitine and Carnitine Esters in the in Vitro Perfused Human Placenta

Transfer across Perfused Human Placenta. IV. Effect of Protein Binding on Free Fatty Acids

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