Transfer across Perfused Human Placenta. IV. Effect of Protein Binding on Free Fatty Acids

Dancis, Joseph; Jansen, Valerie; Levitz, Mortimer

doi:10.1203/00006450-197601000-00002

Cited by 50 publications

(9 citation statements)

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“…This strongly suggests that the placental transfer of fatty acids does not depend on chain length (twelve to twenty carbon atoms), but depends mainly on the concentration in the mother and on foetal uptake; the latter would also seem to depend on concentration. A logarithmic relationship like that found by Dancis, Jansen & Levitz (1976) between FFA clearance and chain length in isolated human placentas was not observed. The correlation of the maternal levels with cord venous-arterial differences in the individual fatty acids (Fig.…”

Section: Checking Experimentsmentioning

confidence: 66%

The transfer of free fatty acids across the rabbit placenta.

Elphick¹,

Hull²

1977

The Journal of Physiology

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SUMMARY1. The passage of fatty acids across the placenta was studied in 28 day pregnant rabbits (i) by comparing the fatty acid distribution in plasma free fatty acids (FFA) of umbilical cord artery and vein with that in maternal plasma and (ii) by infusing the doe at a constant rate with labelled palmitic, linoleic or arachidonic acids. During the infusion maternal and foetal plasma FFA specific activities were measured.2. The mean levels of all the fatty acids studied (from twelve to twenty carbon atoms) were similar in both the umbilical vein plasma and maternal arterial plasma FFA, except for arachidonic acid, which was higher in foetal blood. The relative distribution of the fatty acids in umbilical arterial plasma was similar to that in the vein, but at lower concentrations. The mean cord venous-arterial difference for each fatty acid correlated positively with the mean maternal arterial levels, with the exception of arachidonic acid.3. During the constant infusion experiments the specific activities of the fatty acids in the maternal and foetal circulating FFA pools rose rapidly during the first 4 min then rose only slowly. Palmitic and linoleic acids were cleared from the maternal circulation in a similar manner and crossed the placenta at similar rates.4. The average foetal specific activity in plasma FFA reached 15 % of the maternal level for both palmitate and linoleate. The figure for arachidonic acid was half that for palmitic acid infused at the same time.5. It is concluded that (i) all the major fatty acids present in foetal adipose tissue cross the placenta, (ii) the net transport of each fatty acid depends in part on maternal concentrations, (iii) the rate of metabolism of palmitic and linoleic acids is the same and both cross the placenta at the same rate. Proportionately less foetal arachidonic acid is derived from maternal FFA, and (iv) the results suggest a second placental source of arachidonic acid and possibly also of other fatty acids.

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Section: Checking Experimentsmentioning

confidence: 66%

The transfer of free fatty acids across the rabbit placenta.

Elphick¹,

Hull²

1977

The Journal of Physiology

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“…This may be partly due to the strong binding of palmitoylcarnitine to albumin (Schmidt-Sommerfeld E, unpublished data), and possibly also to placental tissue protein, suggested by the large placental uptake of palmitoylcarnitine during perfusion. Protein binding is known to affect placental transfer of lipophilic compounds (29). There was also no measurable release of labeled long-chain acylcarnitines from the placenta into the perfusates.…”

Section: Discussionmentioning

confidence: 85%

Transfer and Metabolism of Carnitine and Carnitine Esters in the in Vitro Perfused Human Placenta

et al. 1985

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ABSTRAa. The transfer and metabolism of L-carnitine, L-acetylcarnitine, and L-palmitoylcarnitine were studied in the human placenta at term by means of in vitro dual perfusion of a placental lobe. L-Carnitine transfer was 20% that of the freely diffusing antipyrine and 40% that of Llysine. The transfer of L-acetylcarnitine was similar to that of ccarnitine, but no placental transfer of L-palmitoylcarnitine was found. In contrast to L-lvsine. L-carnitine. and -,

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“…In vitro, transfer of saturated free fatty acids is inversely related to their chain length [41], However, placental transfer of free palmitic (Cl 6:0) and linoleic acids (C18:2n-6) is sim ilar despite the different chain length [1] which suggests a favorable effect of polyun saturation on fatty acid transfer. The appar ent preferential transfer of LCP with a higher chain length (20 and 22 carbon atoms) might be attributable to an enhanced affinity to and penetration of the placental membrane by highly unsaturated fatty acids.…”

Section: Discussionmentioning

confidence: 94%

<i>Cis</i>- and <i>Trans</i>-Isomeric Fatty Acids in Plasma Lipids of Newborn Infants and Their Mothers

Koletzko

Müller

1990

Neonatology

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The proportionate fatty acid composition of plasma lipids was determined by high-resolution gas-liquid chromatography in 30 pairs of mothers and their term infants at the time of birth. Trans-fatty acids were found at similar percentage levels in maternal and infantile plasma, evidence for the first time of their placental permeability. In umbilical plasma, linoleic and alpha-linolenic acids contributed markedly smaller portions to total fatty acids, in contrast to clearly higher proportions of their long-chain polyunsaturated metabolites (LCP). Significantly larger percentage values in cord than in maternal plasma were found for those LCP that are structural components of brain lipids, which may reflect a discriminating placental transport mechanism for certain physiologically important LCP.

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Transfer across Perfused Human Placenta. IV. Effect of Protein Binding on Free Fatty Acids

Cited by 50 publications

References 3 publications

The transfer of free fatty acids across the rabbit placenta.

The transfer of free fatty acids across the rabbit placenta.

Transfer and Metabolism of Carnitine and Carnitine Esters in the in Vitro Perfused Human Placenta

<i>Cis</i>- and <i>Trans</i>-Isomeric Fatty Acids in Plasma Lipids of Newborn Infants and Their Mothers

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