In Vitro Metabolite Profiling and Anti-Inflammatory Activities of Rhodomyrtus Tomentosa with Red Blood Cell Membrane Stabilization Methods

Fujiati, Fujiati; Haryati, Haryati; Joharman, Joharman; Utami, Sabrina Wahda

doi:10.52547/rbmb.11.3.502

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…The superior activity of ethyl acetate extract compared with n-hexane and water extract in membrane stabilising was also found in another study (22) . In the previous study comparing the similar polarity of Pp extracts, ethyl acetate extract had the highest flavonoid content (23) .…”

Section: In Vitro Anti-inflammatory Activity Of Extractssupporting

confidence: 61%

Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent

Ayu Kartika,

Suryani,

Setya Palupi

et al. 2023

Indonesian. J. Pharm. Sci.

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Sirih bumi (Peperomia pellucida [L.] Kunth.) is a medicinal herb. Anti-inflammatory activities are reported. These plant extracts have been shown to reduce inflammation in many studies, but it is unknown which extract works best. The objectives if this study were determine the extract that has the best anti-inflammatory activity from sirih bumi. The activity was assessed from the impact of stabilising red blood cell membranes in vitro. The research was then continued with a literature study on the chemical compounds containing the best extracts. To determine the prediction of the compound responsible for its activity and potency, several in silico tests were carried out, such as PASS online, Pre-ADMET online, and Protox II. The test results showed that the ethyl acetate extract at 200 g/mL concentration showed similar activity to aspirin at the same concentration. The activity of this extract increased with increasing concentration of the extract. Six compounds were reported to be isolated from this type of extract. Dillapiol and its derivative 6-allyl-5-methoxy-1,3-benzodioxol-4-ol are predicted to be compounds that have anti-inflammatory effects by inhibiting the membrane permeability mechanism of ethyl acetate extract. Ethyl acetate extract showed the best anti-inflammatory activity among the other type of extract from sirih bumi. Ethyl acetate extract is a type of extract with the best anti-inflammatory activity from sirih bumi.

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Section: In Vitro Anti-inflammatory Activity Of Extractssupporting

confidence: 61%

Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent

Ayu Kartika,

Suryani,

Setya Palupi

et al. 2023

Indonesian. J. Pharm. Sci.

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show abstract

“…Therefore, stabilization of RBC membrane implies stabilization of lysosomal membrane as this membrane is alike to erythrocyte membrane [ 65 ]. Stabilizing membrane and inhibiting denaturation of proteins may be the potential mechanisms employed by plant-derived products for anti-inflammatory activities [ [66] , [67] , [68] , [69] , [70] , [71] ].…”

Section: Discussionmentioning

confidence: 99%

Attenuation of paracetamol-induced hepatotoxicity in Ajuga bracteosa extract treated mice

Ali,

Jan,

Bashir

et al. 2024

Heliyon

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Exploring the therapeutic potential of Annona reticulata extract: molecular docking, dynamics, and ADMET properties for cancer treatment and anti-inflammatory activity

Thangaraj,

Gayathiri,

Prakash

et al. 2024

Journal of Asian Natural Products Research

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In Vitro Metabolite Profiling and Anti-Inflammatory Activities of Rhodomyrtus Tomentosa with Red Blood Cell Membrane Stabilization Methods

Cited by 7 publications

References 19 publications

Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent

Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent

Attenuation of paracetamol-induced hepatotoxicity in Ajuga bracteosa extract treated mice

Exploring the therapeutic potential of Annona reticulata extract: molecular docking, dynamics, and ADMET properties for cancer treatment and anti-inflammatory activity

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