In vitro methods for predicting the bioconcentration of xenobiotics in aquatic organisms

Maculewicz, Jakub; Świacka, Klaudia; Kowalska, Dorota; Stepnowski, Piotr; Stolte, Stefan; Dołżonek, Joanna

doi:10.1016/j.scitotenv.2020.140261

Cited by 13 publications

(3 citation statements)

References 136 publications

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“…ectenes), which is consistent with the results of previous studies . Indeed, it has been suggested that lipids are not the only component that may affect the bioconcentration intensity of pharmaceuticals, making measured concentrations inconsistent with the predicted values based on log K ow values . Log K ow value is usually applied to the partitioning of the neutral forms of hydrophobic organics .…”

Section: Resultsmentioning

confidence: 99%

“…25 Indeed, it has been suggested that lipids are not the only component that may affect the bioconcentration intensity of pharmaceuticals, making measured concentrations inconsistent with the predicted values based on log K ow values. 51 Log K ow value is usually applied to the partitioning of the neutral forms of hydrophobic organics. 24 However, most psychotropic pharmaceuticals are polar molecules and environmental pH may affect their ionization and bioavailability; thus, K ow alone is not a reliable predictor for the bioaccumulation of pharmaceuticals in fish.…”

Section: Bioaccumulation and Influencing Factorsmentioning

confidence: 99%

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Occurrence and Bioaccumulation of Psychotropic Pharmaceuticals and Their Metabolites in Water and Fish in a Shallow Lake in China: Implications for Ecological and Human Health Risks

et al. 2023

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Psychotropic pharmaceuticalsand their metabolites are a growing concern for aquatic environments and may accumulate in aquatic organisms. In this study, 21 parent psychotropic pharmaceuticals and 8 metabolites from three categories of psychotropic drugs (anxiolytics, antiepileptics, and antidepressants) were evaluated in Gao–Bao–Shaobo lake (GBSL), a shallow lake in China. Among them, 18 psychotropic pharmaceuticals and 8 metabolites were detected in water samples from GBSL (0.2 up to ∼24.5 ng/L), and 13 psychotropic pharmaceuticals and 5 metabolites were identified in fish (1 up to ∼126.2 ng/g dw). In the wet season, concentrations of psychotropic pharmaceuticals and their metabolites showed an increase from the inflow to the discharge subarea. Carbamazepine and sertraline were the dominant pharmaceuticals detected in fish with bioaccumulation factors, exceeding 5000 L/kg. Physicochemical parameters (log K ow and MW) were negatively correlated with the pharmaceutical levels in fish. Carbamazepine posed a moderate risk to aquatic organisms in all subareas. Hazard quotient results showed that the consumption of fish from GBSL is unlikely to exhibit a direct adverse effect on humans. Our results indicated that a comprehensive understanding of psychotropic pharmaceutical contaminations in surface waters should consider not only the parent pharmaceuticals but also the subsequent accumulation of their metabolites in fish.

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Section: Resultsmentioning

confidence: 99%

Section: Bioaccumulation and Influencing Factorsmentioning

confidence: 99%

Occurrence and Bioaccumulation of Psychotropic Pharmaceuticals and Their Metabolites in Water and Fish in a Shallow Lake in China: Implications for Ecological and Human Health Risks

et al. 2023

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“…Currently, interest in xenobiotics is restoring due to the recent re-evaluation of dietary antioxidants, namely polyphenols, as moderately harmful compounds rather than authentic antioxidants in vivo [12]. Consequently, the role of xenobiotics in human health is changing.…”

Section: Methodsmentioning

confidence: 99%

Xenobiotics: a Threat to the Health of Living Organisms

2021

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The article summarizes and analyzes the main impacts of various xenobiotics or their groups on the human body and the consequences of such exposure. The study suggests the refinements to the generally accepted classification of xenobiotics’ origins. The paper also describes the molecular mechanism of foreign substances biotransformation in a human body. The metabolism of xenobiotics differs due to their forms and types’ varieties. The factors of influence on chemicals’ metabolism are also of great importance. Individual features of the metabolism may be associated with genetic differences in the activity of metabolic enzymes. The research results further the comprehension of the exposure pathways and health impacts of the xenobiotics and their metabolites.

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The QSAR Paradigm to Explore and Predict Aquatic Toxicity

Tsopelas¹,

Tsantili‐Kakoulidou²

2021

Chemometrics and Cheminformatics in Aquatic Toxicology

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In vitro methods for predicting the bioconcentration of xenobiotics in aquatic organisms

Cited by 13 publications

References 136 publications

Occurrence and Bioaccumulation of Psychotropic Pharmaceuticals and Their Metabolites in Water and Fish in a Shallow Lake in China: Implications for Ecological and Human Health Risks

Occurrence and Bioaccumulation of Psychotropic Pharmaceuticals and Their Metabolites in Water and Fish in a Shallow Lake in China: Implications for Ecological and Human Health Risks

Xenobiotics: a Threat to the Health of Living Organisms

The QSAR Paradigm to Explore and Predict Aquatic Toxicity

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