2015
DOI: 10.1101/cshperspect.a021279
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In Vitro Models for Neurogenesis

Abstract: The process of generating new neurons of different phenotype and function from undifferentiated stem and progenitor cells starts at very early stages of development and continues in discrete regions of the mammalian nervous system throughout life. Understanding mechanisms underlying neuronal cell development, biology, function, and interaction with other cells, especially in the neurogenic niche of fully developed adults, is important in defining and developing new therapeutic regimes in regenerative neuroscie… Show more

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Cited by 44 publications
(44 citation statements)
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“…Neural stem cells are heterogeneous populations comprising bona fide stem cells and also progenitor cells of different neural cell lineages i.e., oligodendroglial, astrocytic, and neuronal progenitors (Azari and Reynolds, 2016 ). When cultured in a proliferative condition in the presence of growth factors, it appeared that safflower seed oil increased the proliferation and stemness property via Notch 1 signaling, as discussed earlier.…”
Section: Discussionmentioning
confidence: 99%
“…Neural stem cells are heterogeneous populations comprising bona fide stem cells and also progenitor cells of different neural cell lineages i.e., oligodendroglial, astrocytic, and neuronal progenitors (Azari and Reynolds, 2016 ). When cultured in a proliferative condition in the presence of growth factors, it appeared that safflower seed oil increased the proliferation and stemness property via Notch 1 signaling, as discussed earlier.…”
Section: Discussionmentioning
confidence: 99%
“…Although much progress has been made in the knowledge of how rodent neurons establish their polarity [1][2][3]5,6 , less is known about the process of neuronal polarization in human cells 7,8 .…”
mentioning
confidence: 99%
“…Futhermore, we demonstrate that hPDLSCs-derived neurons display a sequence of morphologic development highly similar to those observed in primary neuronal cultures derived from rodent brains during neurogenesis, providing strong evidence that it is possible to reproduce neurogenic processes and obtain neurons from hPDLSCs, as suggested by their neural-crest origin and stem cell characteristics [44]. The process of neuronal polarization has been studied for decades using dissociated rodent embryonic hippocampal pyramidal neurons and postnatal cerebellar granule neurons in culture [31,32], but less is known about the process of neuronal polarization in human cells [37,68].…”
Section: Discussionmentioning
confidence: 81%
“…Although future research is required to optimize the diversity of in vitro neural induction protocols that have been designed for oral and dental stem cells [69], our results suggest that hPDLSCs could also be used as an in vitro human cell-based model for neurogenesis and neuronal polarization [37]. In addition, the easy procedure for obtaining these from adults in normal or pathological condictions, may represent, as we have demonstrated with periodontal ligament cells from children [70,71], a suitable way of developing in vitro cell models of human diseases.…”
Section: Discussionmentioning
confidence: 93%
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