In vitro models of human cardiac fibrotic tissue on ‘bioartificial’ scaffolds

Abstract

Cardiac infarction is a global burden worldwide that leads to fibrotic and not contractile myocardial tissue. In this work, in vitro models of infarcted tissue were developed as tools to test novel therapies for cardiac regeneration in the future. Human cardiac fibroblasts were cultured on scaffolds, with different compositions and architectures, as to mimic structural and chemical features of infarcted cardiac tissue. Early findings from in vitro cell tests were reported, showing an enhancement of cell attachment and proliferation in the case of “bioartificial” scaffolds, i.e. scaffolds based on a synthetic and a bioactive polymer.

The Italian Centro 3R: Mission and early achievements presented during the Second Annual Meeting

“…7 Given the extensive expertise on materials and materials engineering in the Centro 3R, many examples of novel scaffolds are reported too. [8][9][10][11][12] In conclusion, these special issues are testament to the depth and breadth of work being performed in Italy as well as the commitment of its scientists to the principles of the 3Rs.…”