In vitro permeation and penetration of ciclopirox olamine from poloxamer 407-based formulations – comparison of isolated human stratum corneum, bovine hoof plates and keratin films

Täuber, Anja; Müller‐Goymann, Christel C.

doi:10.1016/j.ijpharm.2015.04.043

Cited by 30 publications

(23 citation statements)

References 41 publications

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“…Following, permeation coefficients are reported to be up to 30-fold higher in comparison to those obtained with human nails (Mertin and Lippold, 1997a;Mertin and Lippold, 1997b). Regarding the KF, Täuber and Müller-Goymann (2015) found out that permeation coefficients across KF were 1.4 -2.3 times higher than permeation coefficients across bovine hoof plates. Consequently, both nail plate models indicate reduced barrier properties in comparison to the human nail plate.…”

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confidence: 89%

“…The P407-based formulations were 5-component systems consisting of P407, propylene glycol (PG), medium chain triglycerides (MCT) (all purchased from Fagron, Barsbüttel, Germany), double distilled water, isopropyl alcohol (IPA) (received from VWR International, Leuven, Belgium) in given ratios (Täuber and Müller-Goymann, 2015). Since the P407-based formulations are intended for a simultaneous antifungal skin and nail therapy, IPA, MCT and PG were included as skin penetration enhancers (PE).…”

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confidence: 99%

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In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model

Täuber

Müller‐Goymann

2016

International Journal of Pharmaceutics

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confidence: 89%

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confidence: 99%

In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model

Täuber

Müller‐Goymann

2016

International Journal of Pharmaceutics

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“…With respect to the effectiveness of different onychomycosis treatment strategies, various models have been developed recently [ 19 , 20 , 21 ]. Although many of these models use a realistic topical drug application, they have done so on bovine hoof as a keratin source instead of human nail material [ 20 , 21 ]. The nail penetration behavior, however, will also be affected by the presence of fungal growth.…”

Section: Discussionmentioning

confidence: 99%

Effective Single Photodynamic Treatment of ex Vivo Onychomycosis Using a Multifunctional Porphyrin Photosensitizer and Green Light

Hollander

Visser

Haas

et al. 2015

JoF

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Onychomycosis is predominantly caused by the dermatophytes Trichophyton rubrum, Trichophyton mentagrophytes and Trichophyton tonsurans. The main treatment obstacle concerns low nail-plate drug permeability. In vitro antifungal photodynamic treatment (PDT) and nail penetration enhancing effectiveness have been proven for multifunctional photosensitizer 5,10,15-tris(4-N-methylpyridinium)-20-(4-(butyramido-methylcysteinyl)-hydroxyphenyl)-[21H,23H]-porphine trichloride (PORTHE). This study investigates single PORTHE green laser/LED PDT of varying degrees of ex vivo onychomycoses in a human nail model. T. mentagrophytes, T. rubrum, T. tonsurans onychomycoses were ex vivo induced on nail pieces at 28 °C (normal air) and 37 °C (6.4% CO2) during 3 to 35 days and PDTs applied to the 37 °C infections. All dermatophytes showed increasingly nail plate invasion at 37 °C between 7 and 35 days; arthroconidia were observed after 35 days for T. mentagrophytes and T. tonsurans. Using 81 J/cm2 (532 nm) 7-day T. mentagrophytes onychomycoses were cured (92%) with 80 µM PORTHE (pH 8) after 24 h propylene glycol (PG, 40%) pre-treatment and 35-day onychomycoses (52%–67%) with 24 h PORTHE (40–80 µM)/40% PG treatment (pH 5). 28 J/cm2 LED light (525 ± 37 nm) improved cure rates to 72%, 83% and 73% for, respectively, T. mentagrophytus, T. rubrum and T. tonsurans 35-day onychomycoses and to 100% after double PDT. Data indicate PDT relevance for onychomycosis.

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“…Thermoreversibility: In PLOs when the poloxamer concentration is ranging between 20-30% and if they heated above their critical temperature of 20 -25 ºC then they lose their solidmatrix structure and started to flow. Again with increasing the temperature or after cooling the PLOs they return back to their more stable configuration 30,31 .…”

Section: Physio Chemical Properties Of Plos: Viscoelasticitymentioning

confidence: 99%

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2018

IJPSR

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Pluronic lecithin organogels (PLOs) are thermodynamically stable, biocompatible, viscoelastic with improve drug permeation and localised action. PLOs have gained much popularity compared with other traditional topical and transdermal drug delivery system owing to their lower cost, flexibility of dose and longer contact time. PLOs enhances the permeability of drugs because of desired drug partitioning, modification of skin barrier system by its components and biphasic drug solubility that is it enhanced solubility of poorly soluble drugs and increased penetrability of hydrophilic drugs. In this review we discuss the insights of PLOs as topical and transdermal drug delivery system. QUICK RESPONSE CODE

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In vitro permeation and penetration of ciclopirox olamine from poloxamer 407-based formulations – comparison of isolated human stratum corneum, bovine hoof plates and keratin films

Cited by 30 publications

References 41 publications

In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model

In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model

Effective Single Photodynamic Treatment of ex Vivo Onychomycosis Using a Multifunctional Porphyrin Photosensitizer and Green Light

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