In-vitro Permeation and Pharmaco-dynamic Properties of Gel Formulations Containing Tenoxicam Entrapped Niosomes

Sammour, Omaima A.; Marzouk, Maha A.; Ramadan, Afaf A.; Shawky, Seham

doi:10.14511/jlm.2013.010101

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…The lower permeability of GM across rabbit skin in comparison to cellophane membrane may be related to the barrier properties of skin which hinder drug diffusion rates. 10 Results demonstrated that, the obtained transdermal flux values were significantly higher in the case of vesicular formulations (P=0.003). The increase in transdermal flux was associated with a reduction in the lag time, Table 3.…”

Section: Entrapment Efficiencymentioning

confidence: 84%

“…This increase may be related to the action of non-ionic surfactant as penetration enhancer for the drug and the solubilization of lipids within the stratum corneum. 10 Also, the amount of drug permeated from proniosomal gel was significantly higher than that permeated from niosomal gel (P=0.03). The superiority of proniosomal gel can be explained on the basis that, the former contained high ethanol content which was diluted in case of niosomes.…”

Section: Entrapment Efficiencymentioning

confidence: 86%

“…[19] The slower release of drug from niosomal gel formulations may be due to drug encapsulation into vesicles (micro-reservoirs) providing prolonged drug release rate. 10 The proniosomal gel (PN 16 ) gave the lowest drug release among the tested formulations (about 47.5 ± 1.25% after 6 h). This could be related to the condensed vesicular structure composed of Span 60, Tween 60 and Chol (35:35:30), which is considered a great barrier to drug diffusion and a retardant to its release.…”

Section: Entrapment Efficiencymentioning

confidence: 95%

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Enhancing Transdermal Delivery of Glimepiride Via Entrapment in Proniosomal Gel

Abdallah¹,

Sabry²,

Hasan³

2016

JYP

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Objective: The aim of this study is to formulate and evaluate proniosomal gel formulations as transdermal delivery systems of glimepiride (GM) to improve its therapeutic efficacy. Methods: Proniosomal formulations have been prepared using different types of non-ionic surfactants with cholesterol in different molar ratios. Proniosomal gel; PN 16 (Span 60, Tween 60, Cholesterol; 35:35:30 molar ratio) that exhibits maximum EE % (94.01 ± 0.88) and most prolonged release was chosen for ex-vivo skin permeation and in-vivo hypoglycemic activity studies. Results: Proniosomal gel produced better permeation through rabbit skin than HPMC niosomal gel and HPMC gel. The pharmacokinetic parameters; time of maximum response (T max ), % reduction in blood glucose concentration and area above the blood glucose levels-time curve (AAC) of proniosomal gel were studied. Proniosomal gel showed a control led release behavior and a significantly higher hypoglycemic activity (65.34 ± 6.54%). Conclusion: It is evident from this study that proniosomal gel can act as an alternative approach for enhancing transdermal delivery of GM.

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Section: Entrapment Efficiencymentioning

confidence: 84%

Section: Entrapment Efficiencymentioning

confidence: 86%

Section: Entrapment Efficiencymentioning

confidence: 95%

See 1 more Smart Citation

Enhancing Transdermal Delivery of Glimepiride Via Entrapment in Proniosomal Gel

Abdallah¹,

Sabry²,

Hasan³

2016

JYP

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Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species: Inhibition of Nucleic Acid Synthesis

Heilman,

Hui,

Mian

et al. 2023

ChemistrySelect

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Plants are valuable resources for the development of novel pharmaceutical products. The increasing threat to global health caused by antibiotic resistance remains a serious concern, driven a need to discover and evaluate novel anti‐bacterial agents. Calophyllum species are known for having excellent biological activity due to its secondary metabolites, such as xanthone. Numerous xanthones have been found to possess anti‐bacterial properties that are effective against plant pathogens, hence can be applied to fight human pathogens. Topoisomerase enzymes (DNA gyrase and topoisomerase IV) are DNA metabolism enzymes that possess distinct roles as unlinking enzymes during DNA replication. Nucleic acid synthesis inhibition reduces bacteria proliferation through the inhibition of topoisomerase enzymes that are essential for bacterial growth. The xanthone isolated from Calophyllum and its anti‐bacterial were discussed in this review. Besides, molecular docking simulations were applied to explore the potential binding mode of xanthones to DNA metabolism enzymes. The docking study displayed that biscaloxanthone is a good topoisomerase enzymes inhibitor compared to their co‐cystalize ligand, novobiocin and BDBM50198240. The complied information and molecular docking simulations suggested that xanthone isolated possesses potential anti‐bacterial agents inhibiting nucleic acid synthesis. Besides, it suggested that the anti‐microbial activity of xanthone contributes from the topoisomerase enzyme‘s inhibition.

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