In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources

Doan, Thi-Que; Connolly, Lisa; Igout, Ahmed; Nott, Kathérine; Müller, Marc; Scippo, M-L.

doi:10.1016/j.chemosphere.2020.127332

Cited by 19 publications

(9 citation statements)

References 60 publications

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“…Furthermore, PAHs exerted influence over hormone synthesis and metabolism, either by inducing or suppressing the enzymatic pathways involved in hormone production and degradation. These disruptions were not uniform across all PAH compounds [221]; rather, specific PAHs exhibited distinct affinities and mechanisms of action on various hormone receptors. Research into the endocrine-disruptive effects of PAHs underscored the compound-specific nature of these interactions.…”

Section: Molecular and Cellular Level Effectsmentioning

confidence: 95%

Polycyclic Aromatic Hydrocarbons (PAHs) in Freshwater Systems: A Comprehensive Review of Sources, Distribution, and Impacts

Berríos-Rolón,

Cotto,

Márquez

2024

Preprint

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This review paper presents a comprehensive synthesis of current knowledge on the contamination of water systems by polycyclic aromatic hydrocarbons (PAHs). PAHs, organic contaminants characterized by two or more fused aromatic rings, are notably problematic due to their persistence, bioaccumulation, and significant health risks. The review commences with an examination of various sources of PAHs in aquatic environments, encompassing both anthropogenic activities, such as industrial discharges, urban runoff, and oil spills, and natural phenomena including volcanic eruptions and wildfires. Subsequently, the discussion shifts to the distribution patterns of PAHs within different aquatic ecosystems, with an analysis of factors that influence their transport. Considerable focus is placed on the entry mechanisms of PAHs into water systems and their interactions with diverse environmental matrices. Additionally, the ecotoxicological effects of PAHs on aquatic life are scrutinized, with particular emphasis on molecular, individual, and ecosystemic impacts. This includes an exploration of PAH bioaccumulation in aquatic organisms and their potential mutagenic and carcinogenic consequences. The review further addresses the challenges associated with detecting and quantifying PAHs in aquatic settings, reflecting on the advancements in analytical methodologies and the complexities introduced by their varied physicochemical properties. The paper concludes with a summary of existing regulatory frameworks and guidelines governing PAH contamination in water systems, underscoring the imperative for global collaboration in the monitoring and management of PAH pollution.

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Section: Molecular and Cellular Level Effectsmentioning

confidence: 95%

Polycyclic Aromatic Hydrocarbons (PAHs) in Freshwater Systems: A Comprehensive Review of Sources, Distribution, and Impacts

Berríos-Rolón,

Cotto,

Márquez

2024

Preprint

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“…S1: Information on 43 external standards. References [11,[75][76][77][78][79][80][81][82][83][84][85][86][87] are cited in the Supplementary Material.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…Table S1: Information on 43 external standards. References [ 11 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ] are cited in the Supplementary Material.…”

mentioning

confidence: 99%

An Integrated Approach of Bioassays and Non-Target Screening for the Assessment of Endocrine-Disrupting Activities in Tap Water and Identification of Novel Endocrine-Disrupting Chemicals

Liu,

Liu

2024

Toxics

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The safety of drinking water is a significant environmental issue of great concern for human health since numerous contaminants are often detected in drinking water and its sources. Boiling is a common household method used to produce relatively high-quality drinking water in some countries and regions. In this study, with the aid of an integrated approach of in vitro bioassays and non-target analysis based on high-resolution mass spectrometry coupled with liquid chromatography, alterations in endocrine-disrupting activities in tap water samples without and with boiling were revealed, as well as the potential endocrine-disrupting chemicals (EDCs) contributing to these alterations were identified. The organic extracts of tap water had no significant (ant)agonistic activities against an estrogen receptor (ER), progesterone receptor (PR), glucocorticoid receptor (GR), and mineralocorticoid receptor (MR) at enrichment concentrations of ≤10 times, posing no immediate or acute health risk to humans. However, the presence of agonistic activities against PR and MR and antagonistic activities against ER, PR, GR, and MR in OEs of tap water at relatively higher enrichment concentrations still raise potential health concerns. Boiling effectively reduced antagonistic activities against these steroid hormone receptors (SHRs) but increased estrogenic and glucocorticoid activities in drinking water. Four novel potential EDCs, including one UV filter (phenylbenzimidazole sulfonic acid, PBSA) and three natural metabolites of organisms (beta-hydroxymyristic acid, 12-hydroxyoctadecanoic acid, and isorosmanol) were identified in drinking water samples, each of which showed (ant)agonistic activities against different SHRs. Given the widespread use of UV filters in sunscreens to prevent skin cancer, the health risks posed by PBSA as an identified novel EDC are of concern. Although boiling has been thought to reduce the health risk of drinking water contamination, our findings suggest that boiling may have a more complex effect on the endocrine-disrupting activities of drinking water and, therefore, a more comprehensive assessment is needed.

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“…AHR involvement in metabolic disruption has been largely neglected despite a considerable amount of literature linking its activation by environmental contaminants to (eco)-toxicological aspects. AHR is now considered as an endocrine disruptor target like other EATS receptors ( Tq et al, 2020 ); despite this knowledge, much remains unknown about the link between AHR-elicited gene expression and metabolic impairments, and cell-based bioassays are needed to highlight potential metabolic disruptors acting through AHR binding. In this way, luciferase reporter gene assays for AHR have been developed for chemical screening and have proven their efficacy to detect potential AHR activators in environmental mixture ( Boonen et al, 2020 ).…”

Section: Non-eats Modalities Of Concern For Hormonally Active Agentsmentioning

confidence: 99%

“…In contrast, exposure of zebrafish embryos to a mixture of POPs revealed PFOS as the sole chemical responsible for behavioral effects ( Khezri et al, 2017 ), with to a disruption in calcium signaling ( Christou et al, 2020 ). The concentrations of known chemicals detected in a source of drinking water in Belgium were tested for agonistic and antagonistic effects using a panel of rat and human cells expressing AhR, ER, AR, PR and GR promoters linked to a luciferase reporter gene ( Tq et al, 2020 ). Similarly, mixtures of BPA, BPS and BPF had greater agonistic on ER activity and antagonist activity on AR activity with no activity on AhR in reporter cells lines than individual chemicals ( Park et al, 2020 ).…”

Section: Emerging Topics and Considerations For Non-eats Modalities A...mentioning

confidence: 99%

Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities

Martyniuk

Martínez

Navarro‐Martín

et al. 2022

Environmental Research

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In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources

Abstract: In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources. Chemosphere, 258.

Cited by 19 publications

References 60 publications

Polycyclic Aromatic Hydrocarbons (PAHs) in Freshwater Systems: A Comprehensive Review of Sources, Distribution, and Impacts

Polycyclic Aromatic Hydrocarbons (PAHs) in Freshwater Systems: A Comprehensive Review of Sources, Distribution, and Impacts

An Integrated Approach of Bioassays and Non-Target Screening for the Assessment of Endocrine-Disrupting Activities in Tap Water and Identification of Novel Endocrine-Disrupting Chemicals

Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities

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