In-vitro release study of hydrophobic drug using electrospun cross-linked gelatin nanofibers

Laha, Anindita; Yadav, Shital; Majumdar, Saptarshi; Sharma, Chandra Shekhar

doi:10.1016/j.bej.2015.11.001

Cited by 80 publications

(50 citation statements)

References 34 publications

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“…A C C E P T E D M A N U S C R I P T 3 within a short time span [19]. We were able to crosslink the mesh by only a few minutes of GTA exposure (6 min) instead of a few hours or even days as reported in literature [20][21][22].…”

Section: Accepted Manuscriptmentioning

confidence: 51%

“…The probable reason for this kind of common release pattern could be the penetration of water molecules in the mesh which caused swelling of the matrix. Due to swelling, the drug molecules from the outer layers started releasing rapidly, which caused sudden release (65 %) of drug molecules from 6 min crosslinked mesh (G-P NF C6) within 4 h in pH 7.4 [19]. This kind of profile can be used for specific treatment purpose where initial release of drug is required.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The effect of drug concentration and sequential crosslinking on release profile was also investigated. In addition to that, controlling the mobility of hydrophobic drug molecules through hydrophilic polymer matrix is also challenging [19].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The samples were then crosslinked using saturated vapor of GTA (25% v/v aqueous solution) for few minutes (6 and 8 min; i.e. G-P NF C6 and G-P NF C8 respectively) [19].…”

Section: Fabrication Of Nanofiber Membranementioning

confidence: 99%

“…In our previous work, we fabricated single layered piperine loaded (model hydrophobic drug) electrospun gelatin nanofibers (GNF) mesh, and achieved sustained release to some extent as per the gastrointestinal (GI) tract, by controlling the swelling and crosslinking [19]. Due to the highly porous structure of nanofibers, we have crosslinked GNF using saturated vapor of gluteraldehyde (GTA) because of its tremendous capability to crosslink…”

Section: Introductionmentioning

confidence: 99%

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Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Laha

Sharma

Majumdar

2017

Materials Science and Engineering: C

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The aim of this study is to develop electrospun gelatin nanofibers based drug delivery carrier to achieve controlled and sustainable release of hydrophobic drug (piperine) for prolonged time. To accomplish this, we devised some strategies such as sandwiching the drug loaded gelatin nanofiber mesh with another gelatin nanofiber matrix without drug (acting as diffusion barrier), sequential crosslinking and finally, a combination of both. As fabricated multilayered electrospun nanofibers mesh was first characterized in terms of degradation study, morphology, drug-polymer interactions, thermal stability followed by studying their release kinetics in different physiological pH as per the gastrointestinal tract. Our results show that with optimized diffusional barrier support and sequential crosslinking together, a zero order sustained drug release up to 48 h may be achieved with a flexibility to vary the drug loading as per the therapeutic requirements. This work lays out the possibility of systematic design of multilayer nano-fiber mesh of a biopolymer as a drug delivery vehicle for hydrophobic drugs with a desired signature of zero order release for prolonged duration.

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Section: Accepted Manuscriptmentioning

confidence: 51%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The samples were then crosslinked using saturated vapor of GTA (25% v/v aqueous solution) for few minutes (6 and 8 min; i.e. G-P NF C6 and G-P NF C8 respectively) [19].…”

Section: Fabrication Of Nanofiber Membranementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Laha

Sharma

Majumdar

2017

Materials Science and Engineering: C

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Magnetically Controlled Drug Release System through Magnetomechanical Actuation

Barbosa

Correia

Ribeiro

et al. 2016

Adv Healthcare Materials

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A drug release system is developed capable to modulate the drug release kinetics by the application of a magnetic field. Thus, this work reports on the production, characterization, and release kinetics of a poly(l-lactic acid) (PLLA) microporous membrane containing a zeolite (Faujasite) and a magnetic stimuli-sensitive component, magnetostrictive Terfenol-D (TD), for the release of ibuprofen (IBU) as drug model. For membranes containing IBU-loaded zeolites and TD without an applied AC magnetic field, the release kinetics is characterized by a first order release. On the other hand, the application of an AC magnetic field modifies the release profile of the membrane, leading to an increase of the release rate by more than 30%, the magnetically driven release being characterized by a super case-II within the Korsmeyer-Peppas model, indicating a release mainly driven by a swelling or erosion mechanism, induced by the magnetostrictive particles under the applied magnetic field. The increase of the TD w/w from 10% to 20% has as a consequence a decrease in the quantity of IBU released from 79% to 70%; on the contrary, increasing the H intensity from 100 to 200 mT promotes an increase on the percentage of IBU released from 67% to 75%.

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Conductive multichannel PCL/gelatin conduit with tunable mechanical and structural properties for peripheral nerve regeneration

Mohammadi

Ramazani

Mashayekhan

et al. 2020

J of Applied Polymer Sci

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Peripheral nerve injuries remain among the most challenging medical issues despite numerous efforts to devise methods in fabrication of nerve conduits to functionally regenerate axonal defects. In this regard, the current study offers a holistic perspective in design by considering the mechanical, topographical and structural aspects which are crucial for a successful nerve guide conduit. Poly(e‐caprolactone) and gelatin were employed to serve this purpose in the form of dual‐electrospun films which were rolled and later shaped the assembly of a multichannel conduit. Polyaniline/graphene (PAG) nanocomposite was incorporated to endow the conduit with conductive properties. FTIR analysis, water contact angle measurements, and SEM observations as well as mechanical and conductivity tests were used to evaluate the properties of the conduits. In addition, MTT assay was conducted to assess the proliferation of rat bone marrow‐derived mesenchymal stem cells cultured on the films. Incorporating 2% PAG proved to have superior cell support and proliferation, while guaranteeing electrical conductivity of 10.8 × 10−5 S/cm and remarkable tensile strength of 3.52 ± 1.3 MPa and 14.12 ± 3.1 MPa for wet and dry conditions, respectively. Overall, the observed results highlight the great potential of the fabricated conduit to be used as a candidate for peripheral nerve defects.

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In-vitro release study of hydrophobic drug using electrospun cross-linked gelatin nanofibers

Cited by 80 publications

References 34 publications

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Magnetically Controlled Drug Release System through Magnetomechanical Actuation

Conductive multichannel PCL/gelatin conduit with tunable mechanical and structural properties for peripheral nerve regeneration

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