In Vitro Reporter Gene Transfection via Plasmid DNA Delivered by Metered Dose Inhaler

Bains, Baljinder Kaur; Birchall, James Caradoc; Toon, Richard C.; Taylor, Glyn

doi:10.1002/jps.22085

Cited by 17 publications

(15 citation statements)

References 60 publications

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“…pMDIs drug formulations can be solutions or suspensions in a single propellant or propellant mixture and may include excipients such as ethanol or surfactants to solubilize the drug or stabilize a drug suspension. 40 Recently, the use of pMDIs has extended beyond bronchodilators and corticosteroids to deliver proteins, 41 plasmid DNA, 42 and live attenuated virus vaccines or bacteriophages. 43 …”

Section: Pressurized Metered-dose Inhalersmentioning

confidence: 99%

Inhalation drug delivery devices: technology update

Ibrahim¹,

Verma²,

García-Contreras³

2015

MDER

125

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The pulmonary route of administration has proven to be effective in local and systemic delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non-pulmonary diseases. A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient. However, the biggest single problem that accounts for the lack of desired effect or adverse outcomes is the incorrect use of the device due to lack of training in how to use the device or how to coordinate actuation and aerosol inhalation. This review summarizes the structural and mechanical features of aerosol delivery devices with respect to mechanisms of aerosol generation, their use with different formulations, and their advantages and limitations. A technological update of the current state-of-the-art designs proposed to overcome current challenges of existing devices is also provided.

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Section: Pressurized Metered-dose Inhalersmentioning

confidence: 99%

Inhalation drug delivery devices: technology update

Ibrahim¹,

Verma²,

García-Contreras³

2015

MDER

125

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“…Recently, pulmonary administration has become an attractive delivery route for systemically acting drugs because it is noninvasive, avoids first-pass metabolism, and the large lung surface area and thin alveolar epithelium allows fast drug absorption. The localized delivery of protein, peptide, and gene therapy for lung diseases has been explored (173)(174)(175)(176). Though most efforts have been placed on developing dry powder or nebulized formulations to deliver these new therapeutics, the convenience and cost advantages of pMDIs may eventually lead to their use in the delivery of these therapies.…”

Section: New Therapeuticsmentioning

confidence: 99%

“…The retention of lysozyme bioactivity in the HFA formulations was reported to be up to 98%. Bains et al (175) demonstrated that surfactant-coated pDNA nanoparticles can be incorporated into a HFA propellant and the resulting formulation was aerosolizable with the biological functionality of the pDNA retained. While development of pMDI formulations to deliver new therapeutics for systematic and local diseases is still in the infancy stage, these studies demonstrated its viability.…”

Section: New Therapeuticsmentioning

confidence: 99%

Advances in Device and Formulation Technologies for Pulmonary Drug Delivery

et al. 2014

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Inhaled pharmaceuticals are formulated and delivered differently according to the therapeutic indication. However, specific device-formulation coupling is often fickle, and new medications or indications also demand new strategies. The discontinuation of chlorofluorocarbon propellants has seen replacement of older metered dose inhalers with dry powder inhaler formulations. High-dose dry powder inhalers are increasingly seen as an alternative dosage form for nebulised medications. In other cases, new medications have completely bypassed conventional inhalers and been formulated for use with unique inhalers such as the Staccato® device. Among these different devices, integration of software and electronic assistance has become a shared trend. This review covers recent device and formulation advances that are forming the current landscape of inhaled therapeutics.

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“…Temporal adherence depends on the patient perceptions of his disease, satisfaction in the treatment, the cost of the medication, and healthcare access [10,11]. While the adherence to the technique is due to lack of or forget the instructions [12].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Inhalers Technique Proper Use for Patients With Chronic Respiratory Diseases in Primary and Secondary Clinics in Babylon City

Shammer

Baay

2018

Asian J Pharm Clin Res

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Objective: Although the inhalers are the preferred method of medications delivery, evidences suggest that many patients are unable to use their inhalers effectively due to improper technique so patients must know the right way of their inhaler use. The aim of the study is to assess the patient’s ability to use their inhalers properly, identify the most common error made, assess the benefit of single education session, compare the property of the use between the primary and secondary clinics patients, determine which type of the inhaler devices is associated with more errors, and to identify the association between the inhaler technique and the disease control.Methods: Non-randomized interventional study was done on 100 inhaler users of three inhaler types (metered-dose inhaler [p MDI], Turbuhaler, or Handihaler) for chronic respiratory diseases. Inhaler technique was evaluated by a scoring system before and after single session of training.Results: It had been shown that the current education about inhalers techniques was not sufficient. The response to single session of education was higher with high level of education, urban area, and specialized respiratory center. Better disease control with the better score. After training, the younger patients have higher score.Conclusion: We conclude that we need to stress on the most reported defect, metered-dose inhaler had the lowest mean score; therefore, it needs more training. Furthermore, single class of training can be beneficial but need follow-up to see if this effect can be maintained.

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In Vitro Reporter Gene Transfection via Plasmid DNA Delivered by Metered Dose Inhaler

Cited by 17 publications

References 60 publications

Inhalation drug delivery devices: technology update

Inhalation drug delivery devices: technology update

Advances in Device and Formulation Technologies for Pulmonary Drug Delivery

Assessment of Inhalers Technique Proper Use for Patients With Chronic Respiratory Diseases in Primary and Secondary Clinics in Babylon City

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