In vitro schistosomicidal activity of Usnea steineri extract and its major constituent (+)-usnic acid against Schistosoma mansoni

Salloum, Aio; Lucarini, Rodrigo; Tozatti, MG; Medeiros, Juliana Silva de; Silva, Mla; Magalhães, LG; Cunha, WR

doi:10.1055/s-0032-1320991

Cited by 6 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S. mansoni etiologic agent of schistosomiasis mansoni is the most widespread species within its genus in the world, present in 52 countries and territories in tropical and subtropical regions, especially in the Americas, where the presence of this single species is reported [ 48 , 49 ]. Salloum et al [ 50 ] evaluated the in vitro activity of isolated usnic acid from Usnea steineri on S. mansoni couples and reported 100% mortality from worms only at the concentration of 200 μM and in the largest exposure interval 120 h and a complete reduction in fertility/egg production for the same observation interval (Table 1). In addition, through scanning electron microscopy (SEM), discrete integumentary changes in the parasites have been reported, highlighting only peeling and the presence of bubbles.…”

Section: Molluscicidal and Antiparasitic Activitiesmentioning

confidence: 99%

The Natural Compound Hydrophobic Usnic Acid and Hydrophilic Potassium Usnate Derivative: Applications and Comparisons

et al. 2021

View full text Add to dashboard Cite

Usnic acid is the best-studied lichen metabolite, presenting several biological activities, such as antibacterial, immunostimulating, antiviral, antifungal, anti-inflammatory, and antiparasitic agents; despite these relevant properties, it is a hydrophobic and toxic molecule. In this context, scientific research has driven the development of innovative alternatives, considering usnic acid as a source of raw material in obtaining new molecules, allowing structural modifications (syntheses) from it. The purpose is to optimize biological activities and toxicity, with less concentration and/or response time. This work presents a literature review with an analogy of the hydrophobic molecule of usnic acid with its hydrophilic derivative of potassium usnate, emphasizing the elucidation and structural characteristics, biological activities, and toxicological aspects of both molecules, and the advantages of using the promising derivative hydrophilic in different in vitro and in vivo assays when compared to usnic acid.

show abstract

Section: Molluscicidal and Antiparasitic Activitiesmentioning

confidence: 99%