In vitro skin permeation and cellular protective effects of flavonoids isolated from Suaeda asparagoides extracts

Park, Soo Nam; Kim, Sun Young; Lim, Gyu Nam; Jo, Na Rae; Lee, Min Hye

doi:10.1016/j.jiec.2011.11.126

Cited by 28 publications

(19 citation statements)

References 17 publications

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“…사람이 외부 활동하면서 태양광선을 받았을 때, 자외선이 직접적으로 작용하는 부위는 피부에 있어서도 제일 외부에 있는 각질형성세포로 구성된 표피이다 [2,3]. 자 [7][8][9].…”

Section: 서 론unclassified

Antioxidant and Cellular Protective Effects against Oxidative Stress of Calendula officinalis Flowers Extracts in Human Skin Cells

Xuan¹,

Kim²,

Yu³

et al. 2016

Applied Chemistry for Engineering

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In this study, we investigated the total phenolic and flavonoid contents, antioxidant activity and cellular protective effects against oxidative stress on human skin cells in 50% ethanol extract and its fractions of Calendula officinalis (C. officinalis) flowers. We measured the antioxidant effects of 50% ethanol extract and its fractions of C. officinalis flowers on the free radical scavenging activity (FSC50), the reactive oxygen species (ROS) scavenging activities (OSC50) and the inhibition of intracellular ROS generation in human skin cells. These results showed that the antioxidant effect of the ethyl acetate and aglycone fraction was more than the 50% ethanol extract of C. officinalis flowers. We also investigated the cellular protective activity and the results showed that treatment of the ethyl acetate fraction (0.05 -3.13 µg/mL) protects human skin cells in a concentration-dependent manner when the skin cell damages were induced by treating them with H2O2. In addition, the aglycone fraction (1.56 -3.13 µg/mL) shows cellular protective effects on the UV-induced cell damages in a dose-dependent manner. These results suggest that the fractions of C. officinalis flowers can function as a natural antioxidant agent of cosmetics in human skin cells exposed to oxidative stress by ROS scavenging effects.

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Section: 서 론unclassified

Antioxidant and Cellular Protective Effects against Oxidative Stress of Calendula officinalis Flowers Extracts in Human Skin Cells

Xuan¹,

Kim²,

Yu³

et al. 2016

Applied Chemistry for Engineering

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“…이러한 활성산소의 종류로는 singlet oxygen ( [5][6][7]. 따라서 피부에서 생성되는 과잉의 활성산소 생성을 억 제하거나 생성된 활성산소를 효율적으로 제거하고 피 부 항산화 방어망 구축에 보다 적합한 항산화제를 개 발하는 것은 기능성 항노화 화장품 개발에 있어서 매 우 중요하다 [8].…”

Section: 서 론unclassified

Antioxidant and Cellular Protective Effects of Moringa oleifera Leaves Extract

Xuan¹,

Kim²,

Jeong³

et al. 2016

Journal of the Society of Cosmetic Scientists of Korea

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In this study, we investigated the antioxidative and cellular protective effects on HaCaT cells and erythrocytes of Moringa oleifera (M. oleifera) leaves extract and its fractions. All experiments were performed with 50% ethanol extract, ethyl acetate fraction and aglycone fraction of M. oleifera leaves. The free radical scavenging activity (FSC 50 ) of the extract and fractions of M. oleifera leaves were in the following order: 50% ethanol extract (77.10 µg/mL) < ethyl acetate fraction (20.63 µg/mL) < aglycone fraction (17.00 µg/mL) by using the 1, 1-diphenyl-2-picrylhydrazyl. In Fe 3+ -EDTA/H 2 O 2 system using the luminol, reactive oxygen species (ROS) scavenging activities (total antioxidant capacity, OSC 50 ) of aglycone fraction (OSC 50 = 0.63 µg/mL) was the strongest among all extracts, which was much higher than L-ascorbic acid (1.50 µg/mL). In the 1 O 2 -induced cellular damage of erythrocytes, the cellular protective effects of 50% ethanol extract (τ 50 = 46.9 min) and aglycone fraction (τ 50 = 122.1 min) were higher than (+)-α-tocopherol (τ 50 = 37.7 min), known as a lipophilic antioxidant at 10 µg/mL. After cell damage induced by 400 mJ/cm 2 UVB irradiation, the cellular protective effects of ethyl acetate and aglycone fraction of M. oleifera leaves extract were showed on the concentration from 0.20 to 1.56 µg/mL. These results suggest that M. oleifera leaves extract and its fractions can function as a natural antioxidant agent in cosmetics on skin exposed to UV radiation by protecting cellular membrane against ROS.

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“…The aim of this study was to explore the potential of C. sativus petals as a possible source of antioxidants and chemopreventive compounds for use in hydrogels. These hydrogels could be considered an easy, cheap, enriched delivery system for applications either in treatment of difficult wounds or in wound healing masks and beauty masks as well [13,17]. …”

Section: Introductionmentioning

confidence: 99%

New Hydrogels Enriched with Antioxidants from Saffron Crocus Can Find Applications in Wound Treatment and/or Beautification

Zeka

Ruparelia

Sansone

et al. 2018

Skin Pharmacol Physiol

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Saffron extracts have a long history of application as skin protectant, possibly due to their ability to scavenge free radicals. In this work, the performance of a hydrogel enriched with antioxidant compounds isolated from saffron crocus (Crocus sativus L.) petals was tested. These hydrogels could be considered as new drug delivery system. Hydrogels are crosslinked polymer networks that absorb large quantities of water but retain the properties of a solid, thus making ideal dressings for sensitive skin. We tested antioxidant-enriched hydrogels on primary mouse fibroblasts. Hydrogels enriched with kaempferol and crocin extracted from saffron petals showed good biocompatibility with in vitro cultured fibroblasts. These new types of hydrogels may find applications in wound treatment and/or beautification.

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In vitro skin permeation and cellular protective effects of flavonoids isolated from Suaeda asparagoides extracts

Cited by 28 publications

References 17 publications

Antioxidant and Cellular Protective Effects against Oxidative Stress of Calendula officinalis Flowers Extracts in Human Skin Cells

Antioxidant and Cellular Protective Effects against Oxidative Stress of Calendula officinalis Flowers Extracts in Human Skin Cells

Antioxidant and Cellular Protective Effects of Moringa oleifera Leaves Extract

New Hydrogels Enriched with Antioxidants from Saffron Crocus Can Find Applications in Wound Treatment and/or Beautification

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