In-vitro Studies of Pentoxifylline Controlled-Release from Hydrophilic Matrices

Rahman, Bytul M.; Islam, Monirul; Wahed, Mir Imam Ibne; Ahmed, Maruf; Islam, Rubab Tarannum; Barman, Ranjan Kumar; Anisuzzaman, Abu Syed Md; Khondkar, Proma

doi:10.3329/jsr.v1i2.1080

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…Chromatographic HPLC procedures present good selectivity due to the separation in columns but present an environmental disadvantage that is the relatively high volume of organic solvents used. Despite this fact, it can be satisfactorily used for the simultaneous analysis of metformin and other drugs present in the same preparations [18,[23][24][25][26][27][28][29][30][31][32][33].…”

Section: Figurementioning

confidence: 99%

Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug

2016

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This article reports a microgravimetric method for the quantitative determination of metformin in bulk and in pharmaceutical preparations. The analysis is simple and relatively rapid. A complete analysis can be performed in only an hour and thirty minutes due to the drying procedure of the precipitate. However a sample can be treated every each five minutes. The method is based on the reaction of nickel (II) with metformin that in basic medium forms an orange precipitate. The reaction is performed in a plastic syringe. The filtration was done in a glass tube containing a sintered glass disk or in Millipore® syringe filters, with posterior weighing after drying. The analytical results were statistically compared with that obtained with a HPLC and with the titrimetric method suggested by the United States and by the Japanese pharmacopoeias.

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Section: Figurementioning

confidence: 99%

Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug

2016

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“…The fruit of S. macrophylla has been used commercially in health care products for the improvement of blood circulation and skin condition [14]. The seeds are used as an anthelmintic and antidiarrhoeic and also used for the treatment of biliousness and syphilis [15]. In Malaysia, the seeds are used traditionally to treat hypertension, diabetes, and relieve pain [16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antibacterial, Anti-Oxidant and Cytotoxic Activity of Organic Extracts of Mahogany Seeds

Assaduzzaman

Rahman

Uddin

et al. 2020

EJMP

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The perception of normal medicine is changing, and the use of traditional or herbal medicine increasing worldwide due to our harmonious nature of the biological system. Many parts of the plants possess an impressive array of medicinal benefits, mahogany seed is one of them. The aim of this study is to evaluate the antimicrobial, anti-oxidant and cytotoxic activity of organic extracts of mahogany seeds. For determination of antimicrobial and cytotoxic activity disk diffusion and brine shrimp lethality bioassay were used. DPPH free radical test were performed for evaluation of antioxidant activity. Ethanol, n-hexane and aqueous extracts were examined with the total number of 10 bacterial strain. Here, ethanol extract showed higher antimicrobial activity than n-hexane and aqueous extract for both gram positive and negative bacteria. In brine shrimp lethality bioassay LC50 values were 82 μg/ml, 95 μg/ml and 93 μg/ml for ethanol, n-hexane and aqueous extracts respectively. The scavenging DPPH free radicals were found to be concentration dependent. The LC50 value was measured at 140µg/ml, 160µg/ml and 180µg/ml for ethanol, n-hexane and aqueous extract. The results of this study indicated that the mahogany seeds can be used as an easily accessible source of natural antioxidants and Cytotoxic compounds which might be helpful in preventing the progress of various oxidative stresses and cell culture assay.

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“…The change in the rate of drug release was achieved by variation in the amount of HPC and the ratio HPC/PEG (Mircia et al 2010). Rahman et al (2009) studied the release of pentoxifylline from HPMC matrix. Drug release process was controlled by change in the quantity of lactose and starch, containing in the matrix.…”

Section: Introductionmentioning

confidence: 99%

Process optimization of preparation of pentoxifylline – extended release tablets

Tzankov¹,

Tzankov²

2019

PHAR

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The possibilities for correction of the rate of drug release by minimal changes in the technology process and by maintaining the quantitative and qualitative composition of the product pentoxifylline – extended release tablets were explored. Correction was made by addition of different quantity of HPMC (4000 cPs) to a granulating solution of PEG 6000. The main characteristics of the granules (compressibility index and density) were established. The swelling of the hydrogel tablets in water was determined in order more information on the release process to be obtained. Dissolution profiles of produced tablets were determined.

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In-vitro Studies of Pentoxifylline Controlled-Release from Hydrophilic Matrices

Cited by 11 publications

References 18 publications

Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug

Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug

Evaluation of Antibacterial, Anti-Oxidant and Cytotoxic Activity of Organic Extracts of Mahogany Seeds

Process optimization of preparation of pentoxifylline – extended release tablets

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