“…Nevertheless, in spite of a satisfactory osseointegration, this clinical success of dental implants can be guaranteed only if the integrity of periimplant mucosa is maintained by an attachment by hemidesmosomal connection of soft-tissue to the transmucosal implant surfaces. 1,2 On the other hand, it must be emphasized that clinical studies of the interface between gingival tissues and dental implants in humans are hampered by many difficulties, including ethical considerations. Many uncontrollable factors in the oral environment, as well as technical problems on sample preparations, impair experimental studies on soft-tissue behavior.…”