Taurolidine as an effective and biocompatible additive for plaque-removing techniques on implant surfaces

Gordon, John C.; Schwarz, Frank; Becker, Jürgen

doi:10.1007/s00784-014-1337-8

Cited by 12 publications

(13 citation statements)

References 45 publications

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“…Other authors harvested intraoral subgingival plaque and exposed titanium plates in a nutritional solution for seven days [38]. John et al cultivated biofilms by exposing titanium plates fixed on splints for 48 hours in the oral cavity of two specimens [39]. In preparation for this study, we were not able to reproduce the claims of these authors to achieve a mature biofilm covering the complete implant surface in the published timeline, when using a model with intraoral bacteria.…”

Section: Discussionmentioning

confidence: 95%

The Effect of In Vitro Electrolytic Cleaning on Biofilm-Contaminated Implant Surfaces

Ratka

Weigl

Henrich

et al. 2019

JCM

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Purpose: Bacterial biofilms are a major problem in the treatment of infected dental and orthopedic implants. The purpose of this study is to investigate the cleaning effect of an electrolytic approach (EC) compared to a powder-spray system (PSS) on titanium surfaces. Materials and Methods: The tested implants (different surfaces and alloys) were collated into six groups and treated ether with EC or PSS. After a mature biofilm was established, the implants were treated, immersed in a nutritional solution, and streaked on Columbia agar. Colony-forming units (CFUs) were counted after breeding and testing (EC), and control (PSS) groups were compared using a paired sample t-test. Results: No bacterial growth was observed in the EC groups. After thinning to 1:1,000,000, 258.1 ± 19.9 (group 2), 264.4 ± 36.5 (group 4), and 245.3 ± 40.7 (group 6) CFUs could be counted in the PSS groups. The difference between the electrolytic approach (test groups 1, 3, and 5) and PSS (control groups 2, 4, and 6) was statistically extremely significant (p-value < 2.2 × 10−16). Conclusion: Only EC inactivated the bacterial biofilm, and PSS left reproducible bacteria behind. Within the limits of this in vitro test, clinical relevance could be demonstrated.

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Section: Discussionmentioning

confidence: 95%

The Effect of In Vitro Electrolytic Cleaning on Biofilm-Contaminated Implant Surfaces

Ratka

Weigl

Henrich

et al. 2019

JCM

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“…The initial screening of the titles and abstracts identified 58 full texts. After reading the full‐text articles, 10 articles were excluded: three articles due to using the AA in combination with other decontamination methods, one study was not about titanium surface, two articles did not use AA for decontamination, one study was not in English and not published in a peer‐review journal, one study used the AA powder in an antimicrobial solution but did not use the AA device, one study had an in vivo design with decontamination procedures taking place in the beagle dogs, and the full text for one study was not retrieved . The 48 included articles were ultimately processed for data extraction .…”

Section: Resultsmentioning

confidence: 99%

Effects of air abrasive decontamination on titanium surfaces: A systematic review of in vitro studies

Moharrami¹,

Perrotti

Iaculli

et al. 2019

Clin Implant Dent Rel Res

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Background Air abrasion (AA) is one of the decontamination methods that have demonstrated promising results in treating peri‐implant diseases. Purpose This systematic review aimed at evaluating the in vitro effect of AA on surface change, cleaning efficacy, and biocompatibility of titanium surfaces and at comparing it with other decontamination methods. Materials and Methods A comprehensive search was conducted up to April 2018 using PubMed, Scopus, and Google Scholar databases to identify studies on the decontamination effect of AA. All types of titanium surfaces, abrasive powders, contaminated surfaces, and measuring methods were included. Results Overall, 1502 articles were identified. After screening the titles and abstracts, and carefully reading the full‐texts, 48 articles published between 1989 and 2018 were selected. AA was considered almost safe, particularly for the nonmodified surfaces. Nevertheless, harder powders such as sodium bicarbonate tended to damage the surface more than glycine. AA resulted in surface change similar to plastic curettes and Er: YAG lasers. Regarding the cleaning efficacy, there was no significant difference between glycine and sodium bicarbonate, but different mixtures of calcium phosphate, hydroxyapatite, and erythritol were superior to glycine. AA was superior or equal to all other decontamination methods in cleaning. Regarding biocompatibility, AA was more successful in preserving biocompatibility for noncontaminated surfaces compared with contaminated surfaces and when used with erythritol and osteoinductive powders. Conclusions AA can efficiently remove contamination without serious damage to the surface. The main drawback of the AA method seems to be its limitation in restoring the biocompatibility of the surface.

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“…Taurolidine is an effective antibacterial substance [1][2][3][4][5][6][7][8] utilized to counteract catheterrelated infections [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. The substance is further effective against malignancy both, in vivo and in vitro [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Taurolidine Sensitivity of Eryptosis, the Suicidal Erythrocyte Death

Fink

Bhuyan

Zacharopoulou

et al. 2018

Cell Physiol Biochem

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Background/Aims: The taurine derivative Taurolidine is effective against diverse bacteria and tumor growth. In the treatment of cancer, the substance is effective in part by triggering suicidal death or apoptosis of tumor cells. The Taurolidine-induced apoptosis involves mitochondria. Erythrocytes lack mitochondria but are nevertheless able to enter suicidal erythrocyte death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signaling of eryptosis includes increase of cytosolic Ca²⁺ activity ([Ca²⁺]_i), oxidative stress and ceramide. The present study explores, whether Taurolidine induces eryptosis and, if so, which cellular mechanisms are involved. Methods: Phosphatidylserine exposure at the cell surface was estimated using annexin-V-binding, cell volume using forward scatter, [Ca²⁺]_i using Fluo3-fuorescence, reactive oxygen species (ROS) formation using 2’,7’-dichlorodihydrofuorescein (DCF)-dependent fluorescence, and ceramide abundance using specific antibodies. Results: A 48 hours exposure of human erythrocytes to Taurolidine (60 µg/ml) significantly enhanced the percentage of annexin-V-binding cells, significantly decreased forward scatter and significantly increased Fluo3-fluorescence and ceramide abundance, but not DCF-fluorescence. The effect of Taurolidine on annexin-V-binding was virtually abrogated by removal of extracellular Ca²⁺. Conclusion: Taurolidine triggers cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane, an effect at least in part due to Ca²⁺ entry and paralleled by increase of ceramide abundance.

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Taurolidine as an effective and biocompatible additive for plaque-removing techniques on implant surfaces

Abstract: The results of the current study indicate that taurolidine seems to enhance effectiveness of plaque-removing procedures with plastic curettes and glycine powder airflow. Also, the efficiency of both treatment procedures seems to be increased.

Cited by 12 publications

References 45 publications

The Effect of In Vitro Electrolytic Cleaning on Biofilm-Contaminated Implant Surfaces

The Effect of In Vitro Electrolytic Cleaning on Biofilm-Contaminated Implant Surfaces

Effects of air abrasive decontamination on titanium surfaces: A systematic review of in vitro studies

Taurolidine Sensitivity of Eryptosis, the Suicidal Erythrocyte Death

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