1992
DOI: 10.1210/endo.131.2.1639011
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In vitro study of acute toxic effects of high iodide doses in human thyroid follicles.

Abstract: The acute effects of increasing doses of sodium iodide were studied on human thyroid follicles isolated from normal paranodular tissue. After 24 h incubation in culture medium, follicles isolated from most thyroids maintained their capacity for 125I accumulation and organification and a normal cellular ultrastructure. 125I accumulation was significantly increased after addition of TSH, whereas 125I organification was not affected. In presence of TSH, numerous follicles had large empty-looking follicular lumina… Show more

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Cited by 41 publications
(26 citation statements)
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“…As in nonstimulated conditions (19), and in accordance with the theory of redox homeostasis (53), the oxidative stress (OS) to which growing thyrocytes are exposed is harmless, likely because most of it is efficiently detoxified by the well-adapted antioxidant defenses (56,62). In pathological situations, including those simulated in models of iodine-induced thyroid involution (11,(22)(23)(24)(25)(26)63), a higher degree of OS occurs. This intense OS originates from two sources, including the thyrocytes themselves and the numerous interstitial inflammatory cells.…”
Section: Discussionmentioning
confidence: 99%
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“…As in nonstimulated conditions (19), and in accordance with the theory of redox homeostasis (53), the oxidative stress (OS) to which growing thyrocytes are exposed is harmless, likely because most of it is efficiently detoxified by the well-adapted antioxidant defenses (56,62). In pathological situations, including those simulated in models of iodine-induced thyroid involution (11,(22)(23)(24)(25)(26)63), a higher degree of OS occurs. This intense OS originates from two sources, including the thyrocytes themselves and the numerous interstitial inflammatory cells.…”
Section: Discussionmentioning
confidence: 99%
“…ROS are also involved in the hypoxia-inducible factor-mediated vascular endothelial growth factor pathway that is activated in thyrocytes in response to iodine shortage, which makes the endothelial compartment closely related to epithelial cells within the angiofollicular units (16,20,21). Other ROS, including hydroxyl radical (OH ), anion superoxide (O 2 -), peroxynitrite (ONOO -), and iodocompounds, are more reactive and sometimes toxic, as demonstrated in animal models of iodineinduced thyroid involution and in the nonobese diabetic mouse model of spontaneous autoimmune destructive thyroiditis (22)(23)(24)(25)(26).…”
Section: Introductionmentioning
confidence: 99%
“…Significant differences between means were performed after ANOVA by the least significant differences test. The overall variation coefficient of the point counting method was about 6% (Many et al 1992). For morphometric analysis, differences were considered as significant when P<0·05 (not significant=ns).…”
Section: Discussionmentioning
confidence: 99%
“…The second thyroid lobe was carefully dissected, weighed and processed for light and electron microscopy (Many et al 1992); after a further fixation in the same fixative, thyroid fragments were postfixed in 1% osmium tetroxide, dehydrated and embedded in plastic. Semi-thin sections (0·5 µm) were cut from the centre of each fragment and stained with toluidine blue.…”
Section: Morphological and Stereological Analysismentioning
confidence: 99%
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