In vitro study of the cytotoxicity and antiproliferative effects of surfactants produced by Sphingobacterium detergens

Burgos‐Díaz, César; Martín‐Venegas, Raquel; Martı́nez, Verónica; Storniolo, Carolina E; Teruel, José A.; Aranda, Francisco J.; Ortíz, Antonio Gómez; Manresa, Ángeles; Ferrer, Ruth; Marqués, Ana

doi:10.1016/j.ijpharm.2013.06.029

Cited by 28 publications

(15 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biosurfactant produced by Sphingobacterium detergens was studied for its cytotoxicity and antiproliferative effects on different cell lines. When comparing cytotoxicity values (IC 50 ) of the two fractions in fibroblast and keratinocyte cell cultures, fraction B was found less cytotoxic, showing lower toxicity than the reference compound SDS, indicating low skin irritability [ 51 ]. According to the outcomes of present study, BS produced by L. helveticus would be ideal for potential application in cleaning/coating material for several biomedical equipment and cosmetic formulations.…”

Section: Resultsmentioning

confidence: 99%

Production and Structural Characterization ofLactobacillus helveticusDerived Biosurfactant

Sharma

Saharan

Chauhan

et al. 2014

The Scientific World Journal

107

View full text Add to dashboard Cite

A probiotic strain of lactobacilli was isolated from traditional soft Churpi cheese of Yak milk and found positive for biosurfactant production. Lactobacilli reduced the surface tension of phosphate buffer saline (PBS) from 72.0 to 39.5 mNm−1 pH 7.2 and its critical micelle concentration (CMC) was found to be 2.5 mg mL−1. Low cost production of Lactobacilli derived biosurfactant was carried out at lab scale fermenter which yields 0.8 mg mL−1 biosurfactant. The biosurfactant was found least phytotoxic and cytotoxic as compared to the rhamnolipid and sodium dodecyl sulphate (SDS) at different concentration. Structural attributes of biosurfactant were determined by FTIR, NMR (1H and 13C), UPLC-MS, and fatty acid analysis by GCMS which confirmed the presence of glycolipid type of biosurfactant closely similar to xylolipids. Biosurfactant is mainly constituted by lipid and sugar fractions. The present study outcomes provide valuable information on structural characterization of the biosurfactant produced by L. helveticus MRTL91. These findings are encouraging for the application of Lactobacilli derived biosurfactant as nontoxic surface active agents in the emerging field of biomedical applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Production and Structural Characterization ofLactobacillus helveticusDerived Biosurfactant

Sharma

Saharan

Chauhan

et al. 2014

The Scientific World Journal

107

View full text Add to dashboard Cite

show abstract

“…Other less studied glycolipids have also been reported for their potential antitumor promoting activity, for example, the crude glycolipid from Sphingobacterium detergens against Caco2 human colorectal cancer cells [26].…”

Section: Biosurfactants As Antitumor Agentsmentioning

confidence: 99%

Potential therapeutic applications of biosurfactants

Gudiña

Rangarajan

Sen

et al. 2013

Trends in Pharmacological Sciences

315

194

View full text Add to dashboard Cite

Biosurfactants have recently emerged as promising molecules for their structural novelty, versatility, and diverse properties that are potentially useful for many therapeutic applications. Mainly due to their surface activity, these molecules interact with cell membranes of several organisms and/or with the surrounding environments, and thus can be viewed as potential cancer therapeutics or as constituents of drug delivery systems. Some types of microbial surfactants, such as lipopeptides and glycolipids, have been shown to selectively inhibit the proliferation of cancer cells and to disrupt cell membranes causing their lysis through apoptosis pathways. Moreover, biosurfactants as drug delivery vehicles offer commercially attractive and scientifically novel applications. This review covers the current state-of-the-art in biosurfactant research for therapeutic purposes, providing new directions towards the discovery and development of molecules with novel structures and diverse functions for advanced applications.

show abstract

“…Furthermore, Burgos-Díaz and collaborators [28] studied the cytotoxicity and the anti-proliferative effects of a biosurfactant produced by Sphingobacterium detergens in 3T3 fibroblast and HaCaT keratinocyte cell lines after 24 h of exposure. The authors found that the purified fraction of the biosurfactant exhibited lower cytotoxicity than those obtained using SDS, hence indicating low skin irritability.…”

Section: Cytotoxicity Of the Almond O/w Emulsionsmentioning

confidence: 99%

Novel cosmetic formulations containing a biosurfactant from Lactobacillus paracasei

Ferreira

Vecino

Ferreira

et al. 2017

Colloids and Surfaces B: Biointerfaces

109

View full text Add to dashboard Cite

Cosmetic and personal care products including toothpaste, shampoo, creams, makeup, among others, are usually formulated with petroleum-based surfactants, although in the last years the consume trend for "green" products is inducing the replacement of surface-active agents in these formulations by natural surfactants, so-called biosurfactants. In addition to their surfactant capacity, many biosurfactants can act as good emulsifiers, which is an extra advantage in the preparation of green cosmetic products. In this work, a biosurfactant obtained from Lactobacillus paracasei was used as a stabilizing agent in oil-in-water emulsions containing essential oils and natural antioxidant extract. In the presence of biosurfactant, maximum percentages of emulsion volumes (EV=100%) were observed, with droplets sizes about 199nm. These results were comparable with the ones obtained using sodium dodecyl sulfate (SDS), a synthetic well known surfactant with high emulsify capacity. Moreover, the biosurfactant and emulsions cytotoxicity was evaluated using a mouse fibroblast cell line. Solutions containing 5g/L of biosurfactant presented cell proliferation values of 97%, whereas 0.5g/L of SDS showed a strong inhibitory effect. Overall, the results herein gathered are very promising towards the development of new green cosmetic formulations.

show abstract

In vitro study of the cytotoxicity and antiproliferative effects of surfactants produced by Sphingobacterium detergens

Cited by 28 publications

References 47 publications

Production and Structural Characterization ofLactobacillus helveticusDerived Biosurfactant

Production and Structural Characterization ofLactobacillus helveticusDerived Biosurfactant

Potential therapeutic applications of biosurfactants

Novel cosmetic formulations containing a biosurfactant from Lactobacillus paracasei

Contact Info

Product

Resources

About