Skin diseases have recently become a major concern among people of all ages due
to their highly visible symptoms and persistent and difficult treatment, which
significantly impact their quality of life. Nigella sativa seeds, also
known as "black seeds" or "kalonji," are one of
the most commonly used herbal medicines due to their wide range of biological
and pharmacological activities. It contains a wide range of bioactive
constituents found in both fixed and essential oils. It has been used for
hundreds of years as an alternative ethnomedicine to treat a wide range of skin
conditions. N. sativa's dermatological applications in skin
diseases are attributed to its potent antioxidant, anti-inflammatory,
antimicrobial, and immunomodulatory properties, making it an intriguing skincare
candidate. Several studies unravelled positive results associated with N.
sativa on skin diseases. As N. sativa is the most studied
medicinal plant, several preclinical and clinical studies have been conducted to
establish its use in the treatment of various skin diseases. Thymoquinone has
anti-inflammatory, antioxidant, and antibacterial properties, which mainly
contributed to the treatment of skin diseases. In this context, the present
review explores all the available studies on the association of N. sativa
and its effect on treating skin diseases in light of recent studies and patents
supporting its therapeutic applications.