In vitro Targetability Validation of Peptide-Functionalized Mesoporous Silica Nanoparticles in the Presence of Serum Proteins

Paramonov, Valeriy M.; Gerstenberg, Melanie; Sahlgren, Cecilia; Lindén, Mika; Rivero-Müller, Adolfo

doi:10.3389/fchem.2020.603616

Cited by 2 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 These reactions may also be suitable for attaching peptide-containing monomers to nanoparticles for drug delivery. Most peptides are currently attached to amine residues found in polymers or on the surfaces of particles via EDS/ NHS reactions, as described by Rivero-Muller et al 15 These reactions are less efficient and can introduce potentially unwanted byproducts when compared to thiol-ene reactions.…”

Section: Introductionmentioning

confidence: 99%

One pot synthesis of thiol-functional nanoparticles

et al. 2023

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

One pot synthesis of thiol-functional nanoparticles

et al. 2023

View full text Add to dashboard Cite

show abstract

Stimuli‐Responsive Silica Silanol Conjugates: Strategic Nanoarchitectonics in Targeted Drug Delivery

Mohanan

Guan

Liang

et al. 2023

Small

View full text Add to dashboard Cite

The design of novel drug delivery systems is exceptionally critical in disease treatments. Among the existing drug delivery systems, mesoporous silica nanoparticles (MSNs) have shown profuse promise owing to their structural stability, tunable morphologies/sizes, and ability to load different payload chemistry. Significantly, the presence of surface silanol groups enables functionalization with relevant drugs, imaging, and targeting agents, promoting their utility and popularity among researchers. Stimuli‐responsive silanol conjugates have been developed as a novel, more effective way to conjugate, deliver, and release therapeutic drugs on demand and precisely to the selected location. Therefore, it is urgent to summarize the current understanding and the surface silanols’ role in making MSN a versatile drug delivery platform. This review provides an analytical understanding of the surface silanols, chemistry, identification methods, and their property–performance correlation. The chemistry involved in converting surface silanols to a stimuli‐responsive silica delivery system by endogenous/exogenous stimuli, including pH, redox potential, temperature, and hypoxia, is discussed in depth. Different chemistries for converting surface silanols to stimuli‐responsive bonds are discussed in the context of drug delivery. The critical discussion is culminated by outlining the challenges in identifying silanols’ role and overcoming the limitations in synthesizing stimuli‐responsive mesoporous silica‐based drug delivery systems.

show abstract

In vitro Targetability Validation of Peptide-Functionalized Mesoporous Silica Nanoparticles in the Presence of Serum Proteins

Cited by 2 publications

References 24 publications

One pot synthesis of thiol-functional nanoparticles

One pot synthesis of thiol-functional nanoparticles

Stimuli‐Responsive Silica Silanol Conjugates: Strategic Nanoarchitectonics in Targeted Drug Delivery

Contact Info

Product

Resources

About