In-vitro toxicity of molybdenum trioxide nanoparticles on human keratinocytes

Božinović, Ksenija; Nestić, Davor; Centa, Urška Gradišar; Ambriović-Ristov, Andreja; Dekanić, Ana; Bisschop, Lenn de; Remškar, Maja; Majhen, Dragomira

doi:10.1016/j.tox.2020.152564

Cited by 29 publications

(7 citation statements)

References 43 publications

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“…Последствием накопления триглицеридов может стать разрушение лизосом, приводящее к высвобождению в цитоплазму катепсина B, способствующего развитию митохондриальной дисфункции, что усиливает продукцию внутриклеточных свободных радикалов . Свободные радикалы запускают реакции перекисного окисления липидов и усиливают продукцию провоспалительных цитокинов: интерлейкина-6 (IL-6), IL-8, IL-1β, фактора некроза опухоли-альфа (ФНО-α) [Božinović et al, 2020]. Продукты перекисного окисления липидов, ФНО-α и IL-6 способствуют активации клеток Ито (звёздчатые клетки печени), продуцирующих компоненты соединительной ткани, что проявляется в виде фиброза и, при дальнейшем развитии, цирроза .…”

Section: группаunclassified

“…В исследованиях in vivo и in vitro установлена способность НЧ МоО3 усиливать продукцию внутриклеточных активных форм кислорода (АФК) , нарушать функции органоидов, в частности митохондрий , увеличивать синтез провоспалительных цитокинов [Božinović et al, 2020], индуцировать изменения протеомного и метаболомного профилей , нарушать структуру тканей органов ].…”

Section: Introductionunclassified

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Study and comparative evaluation of the toxicity of molybdenum (VI) oxide nanoparticles at a single oral exposure

Zaitseva¹,

Землянова²,

Степанков³

et al. 2022

Вест. ПГУ. Биол.

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The toxic effect of nanoparticles of molybdenum (VI) oxide (MoO3 NPs) after a single oral intake was studied. We administered the test substance as an aqueous suspension at a dose of 2000 mg/kg body weight. Organs were taken from surviving animals 14 days after exposure to study the bioaccumulation of MoO3 NPs and pathomorphological changes caused by the action of this nanomaterial. On the second day after exposure, the death of 50% of the group exposed to NPs was recorded. It has been established that MoO3 NPs accumulate in the heart, lungs, liver, kidneys and brain in concentrations 15.59-221.86 times higher than the control values. In the liver of exposed rats revealed by histological methods the development of hepatitis and microvesicular steatosis; in the lungs – acute bronchitis, vasculitis; in the brain – subarachnoid hemorrhage. MoO3 NPs have a more apparent ability to bioaccumulate and produce toxic effects in comparison with their microdispersed analogue under single oral introductions into the body.

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Section: группаunclassified

Section: Introductionunclassified

Study and comparative evaluation of the toxicity of molybdenum (VI) oxide nanoparticles at a single oral exposure

Zaitseva¹,

Землянова²,

Степанков³

et al. 2022

Вест. ПГУ. Биол.

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Section: Introductionmentioning

confidence: 97%

Application and characterization of a novel PVDF-HFP/PVP polymer composite with MoO3 nanowires as a protective coating for wood

Žigon

Centa

Remškar

et al. 2023

Sci Rep

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The coatings on wood must sometimes give aesthetic and basic protection to wooden elements and prevent the development and transmission of microorganisms. Several polymers containing different nanoparticles have already been offered to day for this purpose. The research presents a novel poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP)/polyvinylpyrrolidone (PVP) polymer composite with MoO3 nanowires with the ability to form coating films on wood. The films of the developed coating exhibit elastic behaviour, which depends on the coating film thickness [tested wet film thicknesses (90, 180 and 360) µm]. The coating showed the ability to interact well with the surface of common beech (Fagus sylvatica L.) wood, in terms of wetting (contact angles of 15.6°), fast spilling on the surface, good penetration of the coating in wood structure and formation of up to 40 µm-thick films with excellent pull-off adhesion strength (6 MPa). An increased roughness of wood coated with C + MoO3 was a consequence of wood etching by the dimethylformamide solvent present in the coating. Moreover, the presence of C + MoO3 on wood made it considerably more hydrophobic, with contact angle of water raising to 123° from initially 46° measured on uncoated wood. The irradiation of wood surfaces with ultra-violet light resulted in visible colour changes on both uncoated and coated wood. The wood coated with C + MoO3 has a good resistance to water, alcohol and dry heat (grade 3 to 4). The antimicrobial testing showed that the presence of MoO3 in the coating plays an important role in the resistance of the coated wood to blue-stain fungi and mould development. The developed PVDF-HFP/PVP/MoO3 coating has an excellent ability to interact with the wood surface and has the potential to be used as a protection for wood in sensitive environments.

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“…In contrast to some other fungicidal compounds, the health risks in the case of MoO 3 are minimal, as Mo is one of the essential elements in trace amounts and is a cofactor for the formation of enzymes in human bodies (Yoshida et al 2006). Otherwise, the 1 hexposure of human keratinocyte cells (HaCaT) to MoO 3 nanowires in concentration up to 1 mg × mL -1 after does not show any effect on cell survival (Božinović et al 2020). Minubaeva (2007) In principle, the diffusion of H 3 O + ions through the cell wall of microbes causes an imbalance in pH value and the cell's enzyme and transport system.…”

Section: Introductionmentioning

confidence: 99%

Application and characterization of a novel PVDF-HFP/PVP polymer composite with MoO3 nanowires as a protective coating for wood

Žigon

Centa

Remškar

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

The coatings on wood must sometimes give aesthetic and basic protection to wooden elements and prevent the development and transmission of microorganisms. Several polymers containing different nanoparticles have already been offered to day for this purpose. A present research presents a novel poly(vinylidene fluoride-co-hexafluoropropylene (PVDF-HFP)/polyvinylpyrrolidone (PVP) polymer composite with MoO3 nanowires with the ability to form coating films on wood. The films of the developed coating exhibit elastic behaviour, which depends on the coating film thickness (tested wet film thicknesses 90 µm, 180 µm and 360 µm). The developed coating showed the ability to interact well with the surface of common beech (Fagus sylvatica L.), in terms of wetting (contact angles of 15.6°), fast spilling on the surface, good penetration of the coating in wood structure, formation of up to 40 µm-thick films with excellent pull-off adhesion strength (6 MPa). An increased roughness of wood coated with C + MoO3 was a consequence of wood etching by the dimethylformamide solvent present in the coating. Moreover, the presence of C + MoO3 on wood made it considerably more hydrophobic, with contact angle of water droplets raising to 123° from initially 46° measured on uncoated wood. The irradiation of wood surfaces with ultra-violet light resulted in colour changes on both uncoated and coated wood, visible to the naked eye. The wood samples coated with C + MoO3 has a good resistance to water, alcohol and dry heat (grade 3 to 4). The antimicrobial testing showed that the presence of MoO3 in the developed coating plays an important role in the resistance of the coated wood blue-stain fungi and mould development. The developed PVDF-HFP/PVP/MoO3 coating has an excellent ability to interact with the wood surface and has the potential to be used as a protective coating for wood in sensitive environments.

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In-vitro toxicity of molybdenum trioxide nanoparticles on human keratinocytes

Cited by 29 publications

References 43 publications

Study and comparative evaluation of the toxicity of molybdenum (VI) oxide nanoparticles at a single oral exposure

Study and comparative evaluation of the toxicity of molybdenum (VI) oxide nanoparticles at a single oral exposure

Application and characterization of a novel PVDF-HFP/PVP polymer composite with MoO3 nanowires as a protective coating for wood

Application and characterization of a novel PVDF-HFP/PVP polymer composite with MoO3 nanowires as a protective coating for wood

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