2006
DOI: 10.1016/j.ultras.2006.07.021
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In vitro ultrasound-mediated leakage from phospholipid vesicles

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Cited by 64 publications
(61 citation statements)
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“…Variations in lipid membrane composition are shown to influence sonosensitivity of liposomes (Pong et al, 2006;Schroeder et al, 2009;Evjen et al, 2010a;Evjen et al, 2010b;Lin et al, 2001). We recently demonstrated that incorporation of DOPE into liposome bilayers drastically enhanced sonosensitivity compared to DSPE-based liposomes and standard liposomal DXR, respectively (Evjen et al, 2011a).…”
Section: Effect Of Dope Level On Sonosensitivitymentioning
confidence: 99%
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“…Variations in lipid membrane composition are shown to influence sonosensitivity of liposomes (Pong et al, 2006;Schroeder et al, 2009;Evjen et al, 2010a;Evjen et al, 2010b;Lin et al, 2001). We recently demonstrated that incorporation of DOPE into liposome bilayers drastically enhanced sonosensitivity compared to DSPE-based liposomes and standard liposomal DXR, respectively (Evjen et al, 2011a).…”
Section: Effect Of Dope Level On Sonosensitivitymentioning
confidence: 99%
“…Recently, there has been increasing interest in using ultrasound (US) as a means to physically and non-invasively trigger drug release from liposomes upon accumulation in tumour tissue (de Smet et al, 2010;Schroeder et al, 2009;Myhr and Moan, 2006;Pong et al, 2006). Local application of US to tumours produces several effects, such as enhancing extravasation of liposomes to tumours, inducing drug leakage from the liposome carrier and enhancing cell membrane permeability with a resulting increased intracellular drug uptake (For recent reviews see Schroeder et al, 2009;Pitt et al, 2004;Frenkel, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…Researchers who have used similar devices to ours to study ultrasonically induced permeation have measured ultrasonic intensities in their devices using a hydrophone and reported values range from 0.03 to 3 W cm À2 . [34,37,43] While these intensities are higher than ultrasonic intensities used for diagnostic applications, they are certainly within the range of therapeutically accessible ultrasonic intensities. [34] G. D. Pangu, K. P. Davis, F. S. Bates, D. A.…”
Section: Discussionmentioning
confidence: 99%
“…A comparison of our results with the studies of ultrasonically induced leakage from liposomes reveals that the percentage leakage from polymer vesicles of similar sizes is comparable to that observed for liposomes. [41,43,44] However most of these studies with liposomes used sonication intervals of less than 10 min for their experiments. Also, a sonication cycle followed by an ultrasound-off period for fluorescence reading may have had a different effect on formation and growth of cavities than simultaneous measurement of fluorescent release during sonication.…”
Section: Discussionmentioning
confidence: 99%
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