In vitro xanthine oxidase inhibitory and antioxidant activities of aerial parts of Flacourtia sepiaria Roxb

Sreejith, M; Kannappan, N.; Santhiagu, A.; Marathakam, Akash; Ajith, P. M.; Jasemine, S.

doi:10.1007/s13596-012-0100-4

Cited by 5 publications

(5 citation statements)

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“…Flacourtia sepiaria was traditionally used as an antidote for snake poisoning, rheumatoid arthritis, gout and kidney diseases. The XOI activity of its methanol extract was found to be significant when compared with standard Allopurinol (Sreejith et al, 2013). Phenolic substances like anthocyanins and polyphenols present in berries of several cultivars of ribes, rubus and vaccinium genera had certain inhibitory activity towards XO (costantino, Albasini and rastelli, 1992).…”

Section: Phytochemical Screening Test 231 Test For Phlobatanninmentioning

confidence: 99%

“…XO is a key enzyme playing a role in hyperuricemia, catalyzing the oxidation of hypoxanthine to xanthine and then to uric acid in nucleotide metabolism (unno, Sugimoto and Kakuda, 2004). Excess or increased activities of XO leads to excessive production of uric acid which gets accumulated in tissues and results in a diseased condition called Gout and rheumatoid Arthritis (Sreejith et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Xanthine Oxidase Inhibitory Effect of Solanum torvum (An in Vitro Study)

Guntupalli¹

2020

Biosci. Biotech. Res. Comm

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Solanum torvum has been used therapeutically for centuries. Pharmacological studies indicate that the stem and root of S.torvum have anti-tumor, anti-bacterial, anti-viral, anti-inflammatory and other medicinally important effects. It is also used to treat fever, wounds and tooth decay. Gout, a disease resulting from increased uric acid accumulation in joints and muscles and due to increased activities of xanthine oxidase enzyme in nucleotide metabolism. Xanthine oxidase converts xanthine to hypoxanthine and further to uric acid. The present study is focused on evaluating the in vitro xanthine oxidase inhibitory (XOI) activity of S. torum fruit extract and to screen the phytochemical constituent present in it. Ethanolic extract of S.torvum (EST) was prepared and xanthine oxidase inhibitory activity was assessed by using Allopurinol as the standard drug. The phytochemical screening of the extract was also done. The results showed that the fruit extract possessed XOI activity in a concentration dependent manner. Also after phytochemical screening showed that EST is rich in phlobatannins, carbohydrates, flavonoids, terpenoids and alkaloids. Thus the study concluded that S.torvum possessed potent in vitro XOI activity.

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Section: Phytochemical Screening Test 231 Test For Phlobatanninmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Xanthine Oxidase Inhibitory Effect of Solanum torvum (An in Vitro Study)

Guntupalli¹

2020

Biosci. Biotech. Res. Comm

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“…Approximately four hundred and twenty seven (427) species of plants are used for medical purposes by the populations of the "plateau Mossi" in Burkina Faso for the treatment of various affections, including the gastrointestinal parasitosis 15 . This traditional medicine that gave better results in the treatment of some diseases where the modern medicine had relative failures 16 , is at present recognized by the national authorities in Burkina Faso where it is integrated in some policies of the health system 17 [24] who realized studies on plants with anthelminthic properties. In this context of research for new active biomolecules the present study was done to test the anthelminthic efficiency of Acacia nilotica var.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Study and In vitro Anthelminthic Properties Studies of the Trunk Barks Aqueous Extract from Acacia Nilotica

Boly¹,

Belemlilga²,

Traore³

et al. 2018

Phyto

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The present study was to estimate the in vitro anthelminthic effect of the aqueous extract of the trunk barks of Acacia nilotica var. adansonii, plant used in this traditional medicine against gastro-intestinal parasites. Trunk barks of Acacia nilotica var. adansonii were used as plant material, eggs and adults worms of Haemonchus contortus were the animal material used. The adult worms and the eggs were put in contact with increasing concentrations of the extract. A phytochemical screening of the plant material was also performed. This study revealed the presence of chemical groups with anthelminthic properties such as tannins, triterpenics, saponosides in the aqueous extract. The vermicide effect was indicated by the lethal concentration of 50% (LC50) of adult worms equal to 1.28 mg / mL compared to the levamisole LC50 which was 3.25 mg / mL. The rate of eggs hatching inhibition was 93.84 % at the extract concentration of 0.1 mg / mL. Anthelminthic properties of Acacia nilotica var. adansonii would be real, which justifies its use in traditional medicine for the treatment of gastrointestinal parasites

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“…XO converts hypoxanthine to xanthine and xanthine to UA in our body [8]. Certain active constituents present in crude plant extracts like flavonoids and polyphenolic compounds have been reported to posses XO inhibitory [9].…”

Section: Introductionmentioning

confidence: 99%

Antihyperuricemic and Xanthine Oxidase Inhibitory Activities of Fractions From Ethanolic Leaves Extract of Stelechocarpus Burahol

Sunarni

2016

Asian J Pharm Clin Res

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Objectives: The aims of the research were to evaluate antihyperuricemic and xanthine oxidase (XO) inhibitory activity of fractions from ethanolic leaves extract of Stelechocarpus burahol. Methods: S. burahol leaves powder was extracted in ethanol by maceration method, then extract was fractionated by liquid-liquid extraction method using n-hexane and ethyl acetate. Hyperuricemic rat model was induced by administered potassium oxonate intraperitoneally. The activity of these fractions on XO inhibitory was determined by measuring the uric acid formation using UV-Vis spectrophotometry method after incubating with XO. Results: The n-hexane and ethyl acetate fractions significantly (p < 0.05) reduce the uric level by 32.0 and 28.0% respectively compared to uric acid level of hyperuricemic group at one hour after drug administration (p < 0.05). On XO inhibitory activity test, only n-hexane fraction exhibited XO inhibitory activity with IC50 541.76 µg/ml. Conclusion: The n-hexane and ethyl acetate fractions from ethanolic leaves extract of S.burahol had antihiperuricemic activity, but less inhibitor effect on XO activity. Keywords: Stelechocarpus burahol, liquid-liquid extraction, antihyperuricemic, xanthine oxidase inhibitory activity

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In vitro xanthine oxidase inhibitory and antioxidant activities of aerial parts of Flacourtia sepiaria Roxb

Cited by 5 publications

References 22 publications

Xanthine Oxidase Inhibitory Effect of Solanum torvum (An in Vitro Study)

Xanthine Oxidase Inhibitory Effect of Solanum torvum (An in Vitro Study)

Phytochemical Study and In vitro Anthelminthic Properties Studies of the Trunk Barks Aqueous Extract from Acacia Nilotica

Antihyperuricemic and Xanthine Oxidase Inhibitory Activities of Fractions From Ethanolic Leaves Extract of Stelechocarpus Burahol

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