In Vivo Analysis of Biodegradable Liposome Gold Nanoparticles as Efficient Agents for Photothermal Therapy of Cancer

Abstract

We report biodegradable plasmon resonant liposome gold nanoparticles (LiposAu NPs) capable of killing cancer cells through photothermal therapy. The pharmacokinetic study of LiposAu NPs performed in a small animal model indicates in situ degradation in hepatocytes and further getting cleared through the hepato-biliary and renal route. Further, the therapeutic potential of LiposAu NPs tested in mouse tumor xenograft model using NIR laser (750 nm) illumination resulted in complete ablation of the tumor mass, thus prolonging disease-free survival.

Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity

“…Although 1 O 2 generation from gold-coated liposomes containing RB was not observed in our study, there is evidence in the literature that PPT induced by gold nanostructures coated on the liposomal surface can damage cancer cells due to local thermal heating. 17,39,40 Therefore, we examined the cell-killing effect of gold-coated liposomes after laser irradiation. As shown in Figure S6, the cell viability was not obviously changed after treatment with gold-coated liposomes containing RB (gold-coated liposomes + RB) and light illumination.…”

“…Here, the leading approach involves coating of liposomebased delivery platform with gold nanostructures. [16][17][18][19] In this scenario, liposomes illuminated with laser light (NIR lasers in most cases) experience a temperature rise causing a phase transition in the lipids, which induces drug release. In addition, the same gold nanostructures may enable photothermal therapy (PPT) of cancer.…”

Nanoparticles in biomedical applications

“…This review investigates other nanosystems such as metallic nanoparticles like gold (Au) [112][113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130] and silver (Ag) , bimetallic nanoparticles like iron cobalt (Fe-Co) [78][79][80][92][93][94][95][96][97]108,109] and iron platinum (Fe-Pt) [155][156][157][158][159][160][161][162][163][164][165][166][167][168][169][170][171][172] and metal oxides including titanium dioxide (TiO 2 ) [1...…”

Real-time cellular and molecular dynamics of bi-metallic self-therapeutic nanoparticle in cancer cells

“…Recent studies have explored several emerging nanoparticlebased potential modalities for drug delivery which implies the use of different cell machineries as targeted delivery system to release a therapeutic payload (Rengan et al 2014(Rengan et al , 2015Krishnamurthy et al 2016). The major focus of nanodrug delivery approaches has been on shape, size, functional moieties and nanoparticle interaction sites on cancer cells.…”