In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase

Zatta, Paolo; Ibn-Lkhayat-Idrissi, M; Zambenedetti, Pamela; Kilyén, Melinda; Kiss, Tamás

doi:10.1016/s0361-9230(02)00836-5

Cited by 145 publications

(76 citation statements)

References 31 publications

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“…This agreed with Gill et al (1991), who reported increased AChE activity in skeletal muscles and brain of a fish species exposed to Cd for 48 hours. Also, Zatta et al (2002) observed increases in AChE activity of rats treated orally with Al.…”

Section: The Activity Of Detoxification Enzymementioning

confidence: 80%

Valuation of water pollution using enzymatic biomarkers in aquatic insects as bioindicators from El-Mansouriya stream, Dakahlia, Egypt

Bream¹,

Amer²,

Haggag³

et al. 2017

Int. J. Adv. Res. Biol. Sci

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This investigation was aimed to evaluate water pollution with heavy metals using three biomarkers, as well as the study of the aquatic insects-seasons interaction. Three species of aquatic insects collected from El-Mansouriya stream (Dakahlia, Egypt), during the different seasons from spring 2014 to winter 2015. Water samples, sediments and whole body of the three aquatic insects were analyzed for heavy metal contents. As well as, two enzyme biomarkers, Acetylcholinesterase (AChE) and glutathione-S-transferase (GST) were used to monitor aquatic insects' response to water pollutants. Results showed various activities of the three biomarkers at the different studied seasons. Where, the concentration of selected heavy metals, in the whole body of the three insects, showed a relatively wide range for each metal analyzed. Also, higher values of metal pollution index (MPI) were attained in hotter seasons (spring and summer) and its decrements were observable during cooler seasons (autumn, winter), that provides a representative picture to the environmental state of environmental impacts on the aquatic ecosystem. While the heavy metals were found to be highly accumulated in selected aquatic insects body, as well as the variation of enzymes activity, thus both enzymes could be used as biomarker of water and sediment contamination.

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Section: The Activity Of Detoxification Enzymementioning

confidence: 80%

Valuation of water pollution using enzymatic biomarkers in aquatic insects as bioindicators from El-Mansouriya stream, Dakahlia, Egypt

Bream¹,

Amer²,

Haggag³

et al. 2017

Int. J. Adv. Res. Biol. Sci

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“…According to several studies, high concentrations of Al and Zn may be associated to the formation of b-amyloid in the brain, which are implicated in Alzheimer's disease (Bush et al 1994;Zatta et al 2002;Kaizer et al 2005;Mekmouche et al 2005); therefore it should not be excluded the hypothesis of these metals being mobilized from the lung, liver or kidney to the brain where they act as neurotoxicants. The levels of apoptotic nuclei, in all organs, were higher in mice from Furnas than in those from Rabo de Peixe.…”

Section: Discussionmentioning

confidence: 99%

Apoptosis, metallothionein, and bioavailable metals in domestic mice (Mus musculus L.) from a human-inhabited volcanic area

et al. 2007

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The influence of extreme environments of volcanic origin over vertebrates and the cellular responses that these may give are almost unknown. The main objectives were to evaluate the exposure of mice to metals in the interior of houses of a small village settled inside a volcanic crater (Furnas, Azores), and the levels of apoptosis and metallothionein in the organs (lung, liver, and kidney) of those animals. Adult mice (Mus musculus) were captured in two areas, one with volcanic activity and the other without it over the last three centuries. In the excised organs, analysis of metals (Al, Cd, Pb, Zn), TUNEL assay for apoptosis, and immunohistochemistry for metallothionein were undertook. Mice from the area with volcanic activity presented higher levels of apoptosis and metallothionein than those from the area without volcanic activity. Such results were in agreement with the differences in metal burdens of the three organs, and interestingly these concentrations were similar to or higher than others found in heavily polluted areas outside the Azores. Thus, there may be a high risk of harmful effects for organisms, including humans, inhabiting areas with volcanism, where hazardous gases and metals in the air are very common during the entire day or even all year round.

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“…Aluminum (Al) a well-known environmentally available neurotoxicant gains an easy access into the central nervous system (CNS) and has been reported to alter the bloodbrain barrier (BBB) under normal physiological conditions and accumulates in the different brain regions 2 . It has been reported to be involved in the etiology of several neurodegenerative diseases such as Alzheimer's disease 3 .…”

Section: Introductionmentioning

confidence: 99%

Phytoconstituents Profile of Clitoria Ternatea by Gc-MS and Its Age-Related Anticholinergic Activity Against Aluminum and Restraint Stress

Lakshmi¹,

Prabhakara²,

Saritha³

et al. 2018

Int. Res. J. Pharm.

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Neurodegenerative diseases are associated with brain aging which leads to impaired cholinergic dysfunction. In the current study, we aimed to identify the neuroprotective effect of Clitoria ternatea (CT) methanolic leaf extract against restraint stress (RS) and aluminum (AlM) induced age-related toxicity in cerebellum of young and adult rats. In CT methanolic leaf extract 9-phytoconstituents such as 4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-hydroxyphenyl); Cyclopentaneundecanoic acid, methyl ester; Phytol; Methyl Isostearate; 12-Methyl-E, E-2,13-Octadecadien-1-ol; Cyclopropaneoctanoic acid, 2-{[2 pentylcyclopropyllmethyl}, methyl ester; Ethanol,2-[9-octadecenyloxy], [Z]; Octadecanoic acid, 5,9,13,17-tetramethyl, methyl ester; Hyocholic acid were identified using Gas chromatography-mass spectrometry (GC-MS), their structures identified based on NIST data, and biological activities were specified. Further, the young (3 months age) and adult rats (12 months age) were randomized into eight groups, control, AlM, RS, CT, RS+AlM, AlM+CT, RS+CT and RS+AlM+CT administered groups. Both the age group rats were restrained in a restraint chamber for 60 min/day/30 days, AlM (100 mg/kg/30 days) and CT leaf extract (50 mg/kg/30 days) were administered orally according to their respective groups. RS and AlM administration showed significant reduced ACh and AChE Cholinergic markers levels in cerebellum compared to control group. Whereas co-administration of CT methanolic leaf extract with RS and AlM showed enhanced levels of ACh and AChE compared to RS and AlM alone treated groups. These data suggest that the rich source of phytoconstituents of CT methanolic leaf extract are responsible for anticholinergic and neuroprotective effects against RS and AlM age-related toxicity.

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In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase

Cited by 145 publications

References 31 publications

Valuation of water pollution using enzymatic biomarkers in aquatic insects as bioindicators from El-Mansouriya stream, Dakahlia, Egypt

Valuation of water pollution using enzymatic biomarkers in aquatic insects as bioindicators from El-Mansouriya stream, Dakahlia, Egypt

Apoptosis, metallothionein, and bioavailable metals in domestic mice (Mus musculus L.) from a human-inhabited volcanic area

Phytoconstituents Profile of Clitoria Ternatea by Gc-MS and Its Age-Related Anticholinergic Activity Against Aluminum and Restraint Stress

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