In Vivo and in Vitro Efficacy of Nigella Sativa Aqueous Extract on Blastocystis Hominis

Eida, Omima M; El-Shafei, Hanaa A.; Nomeir, Yousra A; Safhi, Mohammed B El

doi:10.12816/0026147

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…So, it is considered as the most active concentration of Nigella aqueous extract (El Wakil, 2007). The same result of the concentration of 500 mg/of N. sativa aqueous extract was improved in another study (Eida et al, 2016).…”

Section: Effect Of N Satvia On Protozoa Parasitementioning

confidence: 54%

Effect of Black Seeds (Nigella Sativa) on Some Parasitic Diseases: A Review

2021

Central European Journal of Botany

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Parasitology is a branch of biology that studies the interaction of two microorganisms, one of whom benefits and the other threatens. Previously include Bacteria, Fungi and viruses, now are limited to parasitic protozoa, helminthis, arthropods and species of arthropods serve as a vector for parasite. Six important human tropical illnesses are known and five are parasitic diseases. Parasitic diseases are high prevalence in developing countries where poverty and poor hygiene are predominant. As a result, using chemical drugs is costlier.For thousands of years humans used herbal plants for treatment as a science named herbal medicine (botanical medicines or phytomedicine). Because of their efficacy, safety, low cost, and lesser side effects, traditional herbal medicine is often used as the first line of protection in disease treatment by 80 percent of the world's population.Nigella sativa has been used for medicinal purposes and food from ancients , both as a herb and oil. N. sativa belong to the genus Nigella.This review aims to investigate the possibility of using black seeds as a therapeutic agent in protozoal and helminthic disease based on published data.

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Section: Effect Of N Satvia On Protozoa Parasitementioning

confidence: 54%

Effect of Black Seeds (Nigella Sativa) on Some Parasitic Diseases: A Review

2021

Central European Journal of Botany

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“…Nevertheless, N. sativa in other diseases showed symptomatic improvements in patients with chronic allergic disorders (Koshak, 2019), hepatic steatosis (Kho-nche et al, 2019) and chronic rhinosinusitis (Rezaeian and Amoushahi Khouzani, 2018). It has also been reported that the experimental effect of N. sativa decreases the pathological insult of intestine, liver, spleen and vital organs of mice infected with B. hominis, Toxoplasma and Trypanosoma (Eida et al, 2016;Mady et al, 2016;Nassef et al, 2018).…”

Section: Resultsmentioning

confidence: 95%

“…As anti-Toxoplasma, the combined formula of N. sativa oil and pyrimethamine resulted in a significant increase in mice survival rate and a decrease in parasite density (Mady et al 2016). Aqueous extract of N. sativa had inhibitory effect of Blastocystis hominis in vitro and prevented pathological changes in vivo (Eida et al, 2016). Ethanolic extract and oil of N. sativa have also proven to be the promising anti-helminthic (Schistosoma species and hydatid cyst) substances (Mahmoudvand et al, 2014;Ali et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

“…As the anti-parasitic action, N. sativa has been reported to be effective against many parasites. Its effective potential against protozoa were demonstrated as anti-Leishmania (Mahmoudvand et al, 2015;Abamor andAllahverdiyev 2016), anti-Toxoplasma (Mady et al, 2016), anti-Plasmodium (Okeola et al, 2011;Emeka et al, 2014;JohnsonAjinwo et al, 2018), anti-Trypanosoma (Nassef et al, 2018), and anti-Blastocystis (Eida et al, 2016). It has been effective as well against several helminthes such as the anti-Schistosoma species (Ali et al, 2016), anti-Trichinella (Abu El Ezz, 2005, and antihydatidosis (Mahmoudvand et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Nigella Sativa (Habbet El-Baraka) as a Treatment for Children and Adolescents Infected With Entamoeba Histolytica Complex: A Ranomized Controlled Clinical Trial

Mohamed

Ahmed

Ismail

et al. 2019

Journal of the Egyptian Society of Parasitology

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Amoebiasis is caused by Entamoeba histolytica infection. In African countries amoebiasis is endemic and one of the top 10 causative agents of diarrhea in children. The common diagnostic method for Entamoeba spp. in Egypt is microscopic observation and identification of cysts/trophozoites in fecal samples. It is known that metronidazole (MTZ) is the choice of treatment for amoebiasis. However, drug resistance and side effects are considered to be disadvantages. In this study children and adolescents infected with E. histolytica complex (Eco) have been divided into two groups. As a control treatment, one group received MTZ capsules. The other group (intervention) received herbal medicinal capsules of Nigella sativa (N. sativa) powder to test for its effectiveness against Eco infection and compare its results with the control group. Socio-demographic data, cure rate, recession of symptoms and residual side effects of treatment were evaluated for the patients. In the intervention group, N. sativa showed a cure rate of 78.8% compared to 91.2% in MTZ-control group with no significant difference. Eco infected patients complained about diarrhea, bloody stool and abdominal pain with significant reduction in N. sativa-control group symptoms (from 93.9 to 15.2 %) compared to MTZ. Treatment with MTZ caused several symptomatic residual side effects of metallic taste, anorexia, abdominal pain and diarrhea. After N. sativa treatment, however, no residual symptoms were noted, an indicator of its safety. N. sativa was safe, cost-effective, herb with potential promising effectiveness against Eco infection.

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“…Haridy et al (2006) in Gharbia successfully treated paramphistomiasis infected cows, buffaloes and sheep with Oleo-resin solution of Commiphora molmol (dose of 6 ml of 10gm% equal to 2 Mirazid). Eida et al (2016) reported that N. sativa had inhibitory effect on Blastocystis hominis in vitro and prevented cytopathic effect in infected mice inoculated orally with B. hominis Abroad, Pandey and Eysker (1988) in Zimbabwe among 14 donkeys reported H. muscae in 12 (85.7%). Mfitilodze and Hutchinson (1989) in northern Queensland in 57 horses reported H. muscae in 43%.…”

Section: Introductionmentioning

confidence: 99%