In vivo and in vitro development of serotonergic neurons

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

“…Serotonergic neurons begin to sprout axons by GD 15 (Lidov and Molliver, 1982a,b;Wallace and Lauder, 1983). These axons grow rapidly, and by GD 17 serotonergic axons enter the basal forebrain, with some fibers reaching as far forward as the septum and the frontal pole of the neocortex (Lauder et al, 1982;Lidov and Molliver, 1982a;Wallace and Lauder, 1983). By GD 19 serotonergic axons have established pathways to all major divisions of the forebrain in the rat (Wallace and Lauder, 1983).…”

Serotonergic influence on olfactory learning in the neonate rat

“…In contrast to the numerous roles ascribed to 5-HT in other parts of the CNS, the role of 5-HT in the olfactory bulb has been quite elusive. Indeed, we have found that lack of serotonergic input to the developing olfactory bulb has very little, if any, effect on the cytoarchitecture of that structure (McLean, 1991), even though other studies have suggested such a role in the developing neocortex (Lauder, Wallace, Krebs, Petrusz, & McCarthy, 1982;Lauder, 1990). However, the fact that 5-HT begins to proliferate in the olfactory bulb during the first week of postnatal life (McLean & Shipley, 1987a) and richly innervates the bulb in the adult rat (McLean & Shipley, 1987b) suggests that it has a developmental/functional role in olfaction that begins during early postnatal life.…”

“…Serotonin (5-HT) is involved in such diverse functions and behaviors as sleep (Maeda, Fujimiya, Kitahama, Imai, & Kimura, 1989;Vanderwolf, 1992), locomotion (Motles, Gomez, Briones, & Gonzalez, 1991;Vanderwolf, 1989), mood (Syvalahti, 1987;Curzon, 1988;Burrows, McIntyre, Judd, & Norman, 1988), and developmental differentiation (Lauder, Wallace, Krebs, Petrusz, & McCarthy, 1982;Lauder, 1990). In addition, in combination with cholinergic axons, serotonergic input to the cortex appears to be important for certain memory/learning functions in the adult rat (Sakurai & Wenk, 1990;Normile, Jenden, Kuhn, Wolf, & Altman, 1990).…”

Serotonin uptake, storage, and synthesis in an immortalized committed cell line derived from mouse teratocarcinoma.

“…(ii) Based upon the homogeneity of the induced cell population, each 1C11* cell may contain a low number of functional carrier molecules compared to adult serotoninergic cells. High 5-HT content associated with low 5-HT uptake and tryptophan hydroxylase activity might be properties of committed, but as yet not fully differentiated, cells (51).…”