Tissue Engineering 2010
DOI: 10.5772/8582
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In Vivo and In Vitro Models of Psoriasis

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Cited by 15 publications
(29 citation statements)
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References 92 publications
(155 reference statements)
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“…Higher keratinocyte proliferation values were obtained in the presence of psoriatic fibroblasts (Saiag et al, 1985). Furthermore, this model led to the conclusion that normal fibroblasts are unable to suppress the hyperproliferative growth of psoriatic keratinocytes, and that hyperproliferation of normal epidermis can be induced both by uninvolved and involved psoriatic fibroblasts (Saiag et al, 1985, Jean & Pouliot, 2010.…”
Section: Organ Culturementioning
confidence: 90%
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“…Higher keratinocyte proliferation values were obtained in the presence of psoriatic fibroblasts (Saiag et al, 1985). Furthermore, this model led to the conclusion that normal fibroblasts are unable to suppress the hyperproliferative growth of psoriatic keratinocytes, and that hyperproliferation of normal epidermis can be induced both by uninvolved and involved psoriatic fibroblasts (Saiag et al, 1985, Jean & Pouliot, 2010.…”
Section: Organ Culturementioning
confidence: 90%
“…Thus, the amount of transplant rejection is reduced in the AGR129 model compared to the others. Boyman et al demonstrated that human uninvolved psoriatic skin grafted onto AGR129 mice spontaneously developed psoriatic plaques without the injection of any activated immune cells or any other exogenous factor, suggesting that uninvolved psoriatic skin is not exactly comparable to the normal human skin of healthy patients (Boyman et al, 2004, Gudjonsson et al, 2007, Jean & Pouliot, 2010. However, the absence of an inflammatory system could be a significant weakness of these models, since the importance of the immunology has been described by many research groups.…”
Section: Infiltration Of Inflammatory Cells In the Skinmentioning
confidence: 99%
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