In vivo anticlastogenic effects of l-ascorbic acid in mice

Vijayalaxmi, K.K.; Venu, R.

doi:10.1016/s1383-5718(98)00161-2

Cited by 40 publications

(33 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another possible mechanism is the protection against MMS by reducing the capacity of this chemical to alkylate DNA. Ascorbic acid may compete with DNA as a target for alkylation, reducing the genotoxicity of alkylating agents (Vijayalaxmi and Venu, 1999). The processed juice, conversely, showed an indication of toxicity in strain TA100 and MMS co-mutagenicity in strain TA102 when the pre-treatment protocol was applied (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Antimutagenic activity of cashew apple (Anacardium occidentale Sapindales, Anacardiaceae) fresh juice and processed juice (cajuína) against methyl methanesulfonate, 4-nitroquinoline N-oxide and benzo[a]pyrene

et al. 2008

View full text Add to dashboard Cite

Cashew apple juice (CAJ), produced from the native Brazilian cashew tree (Anacardium occidentale), and has been reported to have antibacterial, antifungal, antitumor, antioxidant and antimutagenic properties. Both the fresh unprocessed juice and the processed juice (cajuína in Portuguese) has been shown to consist of a complex mixture containing high concentrations of anacardic and ascorbic acids plus several carotenoids, phenolic compounds and metals. We assessed both types of juice for their antimutagenic properties against the direct mutagens methyl methanesulfonate (MMS) and 4-nitroquinoline-N-oxide (4-NQO) and the indirect mutagen benzo[a]pyrene (BaP) using pre-treatment, co-treatment and post-treatment assays with Salmonella typhimurium strains TA100, TA102, and TA97a. In pre-treatment experiments with strains TA100 and TA102 the fresh juice showed high antimutagenic activity against MMS but, conversely, co-treatment with both juices enhanced MMS mutagenicity and there was an indication of toxicity in the post-treatment regime. In pre-, co-, and post-treatments with TA97a as test strain, antimutagenic effects were also observed against 4-NQO and BaP. These results suggest that both fresh and processed CAJ can protect the cells against mutagenesis induced by direct and indirect mutagens.

show abstract

Section: Resultsmentioning

confidence: 99%

Antimutagenic activity of cashew apple (Anacardium occidentale Sapindales, Anacardiaceae) fresh juice and processed juice (cajuína) against methyl methanesulfonate, 4-nitroquinoline N-oxide and benzo[a]pyrene

et al. 2008

View full text Add to dashboard Cite

show abstract

“…The antioxidant activity of BC is mainly attributed to its high vitamin C (VC) content [BCN = 1960 mg VC/0.1 kg pulp, Düsman et al (2014), and BCF = 1232 mg VC/0.1 kg pulp]. The antimutagenic activity of VC has been confirmed in other studies, in particular, by Vijayalaxmi and Venu (1999), with concentrations of 10, 30 and 60 mg/kg of this vitamin inhibiting the genotoxicity of CP (50 mg/kg), using test-system cells derived from the bone marrows of mice treated in vivo, in a manner similar to the present study. Nunes et al (2011) corroborated this finding, stating that the protective effects exerted by BC may be related to VC and its complex mixture of nutrients.…”

Section: Resultsmentioning

confidence: 83%

In vivo antimutagenic effects of the Barbados cherry fruit (Malpighia glabra Linnaeus) in a chromosomal aberration assay

et al. 2016

View full text Add to dashboard Cite

“…Our results showed that concurrent administration of VC inhibited the DNA damage and chromosome aberrations induced by TMT in all tested doses. This ameliorative effect induced by VC may be resulted from enhancement of detoxification pathways that convert this reactive compound to less toxic and more easily excreted products (Vijayalaxmi and Venu 1999) and/or through its action as the free radical scavenging efficiency (Chaudiere and Ferrari-Iliou 1999). In addition, numerous in vitro and in vivo studies have evaluated the protective effects of VC against several radical generating chemicals (Blasiak and Kawalik 2001, Blasiak et al 2004, Arranz et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Vitamin C on Trimethyltin Induced DNA Damage Using Comet Assay and Chromosomal Aberrations

Farghaly¹,

Abo-Zeid²

2010

CYTOLOGIA

View full text Add to dashboard Cite

SummaryThe objective of this study is to investigate the utility of comet assay and chromosome aberrations analysis for detecting the possible antimutagenic activity of vitamin C to reduce the genotoxic effect of Trimethyltin (TMT). TMT is one of the organotin compounds which is widely used as polyvinyl chloride heat stabilizers and marine biocides. In this study, male Swiss mice were treated interapretoneally (i.p.) with 3 tested doses 0.25, 0.50 and 1.0 mg TMT/kg b.wt. for 1, 2 and 3 d. Alkaline comet assay in nucleated bone-marrow cells and chromosome analysis in spermatocytes were performed 24 h after the last treatment. The amount of DNA damage in cells was estimated from comet tail length as the extent of migration of the genetic material. A significant increase in comet tail length indicating DNA damage was observed at all concentrations compared with control ( pϽ0.05). The mean comet tail length showed a concentration-related and timedependent increase. Also, the percentage of chromosome aberrations in spermatocytes was statistically significant (pϽ0.05) and showed dose and time dependent manner. Concurrent administration of vitamin C (VC) orally at 20 mg/kg b.wt. with the highest dose of TMT for 1, 2 and 3 d reduced DNA damage in somatic and germ cells to a significant extent. In conclusion, our results indicated that vitamin C ameliorated DNA damage and genotoxicity induced by trimethyltin in mice somatic and germ cells in vivo.

show abstract

In vivo anticlastogenic effects of l-ascorbic acid in mice

Cited by 40 publications

References 22 publications

Antimutagenic activity of cashew apple (Anacardium occidentale Sapindales, Anacardiaceae) fresh juice and processed juice (cajuína) against methyl methanesulfonate, 4-nitroquinoline N-oxide and benzo[a]pyrene

Antimutagenic activity of cashew apple (Anacardium occidentale Sapindales, Anacardiaceae) fresh juice and processed juice (cajuína) against methyl methanesulfonate, 4-nitroquinoline N-oxide and benzo[a]pyrene

In vivo antimutagenic effects of the Barbados cherry fruit (Malpighia glabra Linnaeus) in a chromosomal aberration assay

Protective Effect of Vitamin C on Trimethyltin Induced DNA Damage Using Comet Assay and Chromosomal Aberrations

Contact Info

Product

Resources

About