In vivo antimutagenic effects of the Barbados cherry fruit (Malpighia glabra Linnaeus) in a chromosomal aberration assay

Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.

“…Plants extracts belonging to the Malpighiaceae family also present other potential pharmacological properties, such as antimicrobial, wound healing and antitumor (Düsman et al 2016, Specian et al 2016.…”

Acerola (Malpighia spp.) Waste: A Sustainable Approach to Nutraceutical, Pharmaceutical, and Energy Applications

“…Acerola juice mixed with other fruits showed high antiproliferative and antimutagenic activities against alterations induced by cyclophosphamide, possibly attributed to its high content of bioactive compounds [94]; acerola pulp juice showed potential as an antimutagenic by statistically reduced the percentages of chromosomal alterations induced by this compound [91]. Research developed by Düsman et al (2016) also demonstrated that the consumption of acerola showed antimutagenic effects against iodine-131 in acute and subchronic treatments, mainly by acting in the capture of free radicals produced by radiation [91]. Research developed by Almeida et al (2014) also demonstrates the potential of acerola extracts to reduce 131-I-induced damage [92].…”

“…Antimutagenic compounds reduce the frequency of spontaneous or induced mutations; vitamin C, polyphenols, and carotenoids can reduce oxidative stress levels and quench free radicals, reducing the damage and promoting the protection of DNA against oxidative damage, showing antioxidant and antimutagenic effects [86,87]. Some compounds, such as cyclophosphamide (CP) [91], iodine-131 [92], and hydrogen peroxide [93], may result in undesirable side effects and cause cellular mutations in organisms. Acerola juice mixed with other fruits showed high antiproliferative and antimutagenic activities against alterations induced by cyclophosphamide, possibly attributed to its high content of bioactive compounds [94]; acerola pulp juice showed potential as an antimutagenic by statistically reduced the percentages of chromosomal alterations induced by this compound [91].…”

“…Some compounds, such as cyclophosphamide (CP) [91], iodine-131 [92], and hydrogen peroxide [93], may result in undesirable side effects and cause cellular mutations in organisms. Acerola juice mixed with other fruits showed high antiproliferative and antimutagenic activities against alterations induced by cyclophosphamide, possibly attributed to its high content of bioactive compounds [94]; acerola pulp juice showed potential as an antimutagenic by statistically reduced the percentages of chromosomal alterations induced by this compound [91]. Research developed by Düsman et al (2016) also demonstrated that the consumption of acerola showed antimutagenic effects against iodine-131 in acute and subchronic treatments, mainly by acting in the capture of free radicals produced by radiation [91].…”

Viabilidade da obtenção de polpa de acerola (malpighia spp) microencapsulada e liofilizada: Uma revisão

“…Os resultados justificam o uso adicional das misturas para enriquecimento de produtos para prevenção de doenças crônicas. É demonstrado em pesquisas diversas atividades biológicas como: atividade antioxidante, antimutagênica, antidiabética, antitumoral e hepatoprotetora (Paz et al, 2015;Düsman, Almeida, Tonin, & Vicentini, 2016;Barbalho et al, 2011;Luveena, Karthiayini, & Sreekumar, 2012).…”