In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb

Prokopenko, Yuliya; Tsyvunin, Vadim; Shtrygol, S. Yu.; Georgiyants, Victoriya

doi:10.3390/scipharm84030547

Cited by 15 publications

(8 citation statements)

References 9 publications

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“…The existing scientific reports cite anticonvulsant activity, especially for F. schleicheri Soy.-Will. [ 27 , 28 ]. No scientific data about polyphenols exists on F. jankae to date, as it is an endemic species, present only in a specific geographic region of Romania.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species

et al. 2017

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Romanian traditional medicine describes the use of aerial parts of Fumaria species to treat hepatobiliary diseases as well as diuretic agents. The present study aims to investigate the chemical composition, antioxidant properties, and diuretic effects of several Fumaria species. LC/MS analysis revealed that Fumaria species contain phenolic acids and high amounts of flavonoids with rutin and isoquercitrin as main compounds. Concerning antioxidant capacity, the most significant results were obtained for F. capreolata and F. vailantii. Both species showed a good correlation between the antioxidant capacity and a high amount of flavonoids. Furthermore, the extracts of F. officinalis and F. schleicheri produced a strong increase in urinary volumetric excretion of saline-loaded rats, 24 h after the oral administration of a single dose of 250 mg/kg bw. Moreover, both extracts of F. officinalis and F. schleicheri increased the urinary excretion of Na+ and K+. Results from the present study offer a new perspective concerning the chemical composition and bioactivities of traditionally used fumitory species.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species

et al. 2017

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“…The literature survey of some of the chemical principles found in the fractions of C. adiantifolia mentioned above reveals the medicinal value of the plant species. Protopine; an alkaloid, has been reported for its anticonvulsant activity, 20 microtubule-stabilizing effects, 21 antiinflammatory activity reducing effects, 22 neuroprotective effects, [23][24] anticholinesterase effects, 25 etc. Sanguinarine compounds have been reported for anticancer, [26][27] anti-osteoporosis, [28][29] and norsanguinarine has been reported for antifungal activity.…”

Section: Resultsmentioning

confidence: 99%

GC-MS Analysis of Phytoconstituents in Fractions of Corydalis adiantifolia

Ali¹,

Khan²,

Khan³

et al. 2018

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“…In a pentylenetetrazol-induced seizure mouse model, with sodium valproate as the reference, protopine showed some anticonvulsant activity, significantly prolonged the latency of seizures, shortened the duration of convulsions, and significantly reduced the severity of convulsions. In addition, the anticonvulsant effect of protopine (0.005, 0.05 mg/kg) was dose-dependent [ 71 ]. Kardos et al found that protopine (0.1, 1, 10 μM) enhanced the binding of 3H-gamma-aminobutyric acid (3H-GABA) to rat brain synaptic membrane receptors, increased GABA-mediated Cl − influx, led to membrane hyperpolarization, decreased membrane excitability, and exerted its sedative and anticonvulsant effects [ 72 ].…”

Section: Pharmacological Activities Of Protopinementioning

confidence: 99%

Identification and Quantification, Metabolism and Pharmacokinetics, Pharmacological Activities, and Botanical Preparations of Protopine: A Review

et al. 2021

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Through pharmacological activity research, an increasing number of natural products and their derivatives are being recognized for their therapeutic value. In recent years, studies have been conducted on Corydalis yanhusuo W.T. Wang, a valuable medicinal herb listed in the Chinese Pharmacopoeia. Protopine, one of its components, has also become a research hotspot. To illustrate the identification, metabolism, and broad pharmacological activity of protopine and the botanical preparations containing it for further scientific studies and clinical applications, an in-depth and detailed review of protopine is required. We collected data on the identification and quantification, metabolism and pharmacokinetics, pharmacological activities, and botanical preparations of protopine from 1986 to 2021 from the PubMed database using “protopine” as a keyword. It has been shown that protopine as an active ingredient of many botanical preparations can be rapidly screened and quantified by a large number of methods (such as the LC-ESI-MS/MS and the TLC/GC-MS), and the possible metabolic pathways of protopine in vivo have been proposed. In addition, protopine possesses a wide range of pharmacological activities such as anti-inflammatory, anti-platelet aggregation, anti-cancer, analgesic, vasodilatory, anticholinesterase, anti-addictive, anticonvulsant, antipathogenic, antioxidant, hepatoprotective, neuroprotective, and cytotoxic and anti-proliferative activities. In this paper, the identification and quantification, metabolism and pharmacokinetics, pharmacological activities, and botanical preparations of protopine are reviewed in detail to lay a foundation for further scientific research and clinical applications of protopine.

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In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb

Cited by 15 publications

References 9 publications

Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species

Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species

GC-MS Analysis of Phytoconstituents in Fractions of Corydalis adiantifolia

Identification and Quantification, Metabolism and Pharmacokinetics, Pharmacological Activities, and Botanical Preparations of Protopine: A Review

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