In vivo antioxidant assessment of two antimalarial plants–Allamamda cathartica and Bixa orellana

Conrad, Omonhinmin A.; Dike, I. P.; Agbara, Uche

doi:10.1016/s2221-1691(13)60082-9

Cited by 30 publications

(19 citation statements)

References 16 publications

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“…The antioxidant and free radical scavenging activities of extracts of Bixa leaves were also demonstrated by several other research groups (Islam et al, 2011;Viuda-Martos et al, 2012;Conrad et al, 2013). Viuda-Martos et al (2012) showed that ethanol extracts of Bixa leaves exhibited significant antioxidant activity based on five different assay systems.…”

Section: Anti-inflammatory Antioxidant and Analgesic Activitiessupporting

confidence: 57%

“…Viuda-Martos et al (2012) showed that ethanol extracts of Bixa leaves exhibited significant antioxidant activity based on five different assay systems. Conrad et al (2013) found that ethanol extracts of Bixa plants inhibited free radical induced lipid peroxidation, enhanced blood and hepatic reduced glutathione levels and increased catalase activity in carbon tetrachloride-treated rats.…”

Section: Anti-inflammatory Antioxidant and Analgesic Activitiesmentioning

confidence: 93%

“…The antioxidant and free radical scavenging activities of extracts of Bixa leaves were also demonstrated by several other research groups (Islam et al ., ; Viuda‐Martos et al ., ; Conrad et al ., ). Viuda‐Martos et al .…”

Section: Anti‐inflammatory Antioxidant and Analgesic Activitiesmentioning

confidence: 99%

“…Conrad et al . () found that ethanol extracts of Bixa plants inhibited free radical induced lipid peroxidation, enhanced blood and hepatic reduced glutathione levels and increased catalase activity in carbon tetrachloride‐treated rats.…”

Section: Anti‐inflammatory Antioxidant and Analgesic Activitiesmentioning

confidence: 99%

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Safety and Efficacy of Bixa orellana (Achiote, Annatto) Leaf Extracts

Stohs

2013

Phytotherapy Research

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Bixa orellana leaf preparations have been used for many years by indigenous people for a variety of medicinal applications. Published research studies in animals indicate that various extracts of Bixa leaves exhibit antioxidant, broad antimicrobial (antibacterial and antifungal), anti-inflammatory, analgesic, hypoglycemic, and antidiarrheal activities. No studies have specifically assessed the ability of leaf extracts to inhibit urogenital infections although Bixa products have been used in folkloric medicine to treat gonorrhea and other infections. Few human studies have been conducted and published using Bixa leaf preparations. Many more studies have been conducted and published involving Bixa seed (annatto) extracts than with leaf extracts. No subchronic safety (toxicity) studies have been conducted in animals. A 6 month study in humans given 750 mg of leaf powder per day demonstrated no significant or serious adverse effects. Bixa leaf extracts appear to be safe when given under current conditions of use. However, additional human and animal controlled safety and efficacy studies are needed. In addition, detailed chemical analyses are required to establish structure-function relationships.

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Section: Anti-inflammatory Antioxidant and Analgesic Activitiessupporting

confidence: 57%

Section: Anti-inflammatory Antioxidant and Analgesic Activitiesmentioning

confidence: 93%

Section: Anti‐inflammatory Antioxidant and Analgesic Activitiesmentioning

confidence: 99%

Section: Anti‐inflammatory Antioxidant and Analgesic Activitiesmentioning

confidence: 99%

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Safety and Efficacy of Bixa orellana (Achiote, Annatto) Leaf Extracts

Stohs

2013

Phytotherapy Research

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“…The standard drug, CQ caused chemosuppression, which was higher than those of the extract treated groups. It has been reported that the antioxidant potential was related to antimalarial activity in several plant extracts [21][22][23][24]. Hence, flavonoids and polyphenolic compounds in Siamese neem tree, and its potent antioxidant activity might play a role to inhibit PbANKA growth in vivo.…”

Section: Discussionmentioning

confidence: 98%

Antimalarial and Anti-hypoglycemic Properties of Siamese Neem Tree (Azadirachta indica) in Plasmodium berghei Infected Mice

Somsak¹,

Chachiyo²

2015

Malaria Contr Elimination

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The present study has been carried out to investigate antimalarial and anti-hypoglycemic activities of leaf aqueous crude extract of Siamese neem tree (Azadirachta indica) against Plasmodium berghei infected mice. Groups of ICR mice were treated orally with Siamese neem tree extract (500, 1000, and 2000 mg/kg) after infection with P. berghei ANKA. Parasitemia and blood glucose levels were determined. At these doses, Siamese neem tree extract inhibited parasitemia in dose-dependent manner with significance (P < 0.05). In addition, anti-hypoglycemic activity has been observed in infected mice treated with Siamese neem tree extracts. In particularly, the highest activities of Siamese neem tree extract were found at dose 2000 mg/kg. These results indicated that leaf aqueous crude extract of Siamese neem tree have antimalarial and anti-hypoglycemic activities against P. berghei ANKA infected mice.

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Herbal Medicine Methods and Practices in Nigeria

Iyiola,

Adegoke Wahab

2023

Reference Series in Phytochemistry

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In vivo antioxidant assessment of two antimalarial plants–Allamamda cathartica and Bixa orellana

Cited by 30 publications

References 16 publications

Safety and Efficacy of Bixa orellana (Achiote, Annatto) Leaf Extracts

Safety and Efficacy of Bixa orellana (Achiote, Annatto) Leaf Extracts

Antimalarial and Anti-hypoglycemic Properties of Siamese Neem Tree (Azadirachta indica) in Plasmodium berghei Infected Mice

Herbal Medicine Methods and Practices in Nigeria

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