In Vivo Antioxidative Activity of Propolis Evaluated by the Interaction with Vitamins C and E and the Level of Lipid Hydroperoxides in Rats

Sun, Fang; Hayami, Shoko; Haruna, Sakiko; Ogiri, Yukako; Tanaka, Kyoko; Yamada, Yasuko; Ikeda, K; Yamada, Hideo; Sugimoto, H.; Kawai, Nobuyuki; Kojo, Shosuke

doi:10.1021/jf990594t

Cited by 61 publications

(38 citation statements)

References 34 publications

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“…[34][35][36] Our results also show that honey is able to reduce the generation of lipid hydroperoxide. This is consistent with results reported by Sun et al 37 that propolis (a resinous material collected by bees from gum exudates of trees) could reduce levels of lipid hydroperoxides in vitamin E-deficient rats. In general, it has been reported that honey can prevent deteriorative oxidative reactions in foods, such as lipid oxidation.…”

Section: Discussionsupporting

confidence: 93%

Antioxidant Capacity of Venezuelan Honey in Wistar Rat Homogenates

Pérez

Rodrı́guez-Malaver

Vit

2006

Journal of Medicinal Food

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The antioxidant effect of several polyphenolic compounds is well known. However, little is known about the antioxidant capacity of Venezuelan honey, which has a high content of polyphenolic compounds. In this work, the antioxidant capacity of a genuine honey produced in Mérida, Venezuela was studied using the ferrous iron oxidation with xylenol orange method, the thiobarbituric acid method, and the determination of antioxidant activity. We found that this honey has the capacity to decrease significantly the concentration of lipid hydroperoxides and malondialdehyde, produced during the lipid peroxidation process, in a comparable way with other widely studied antioxidants such as melatonin and vitamin E. It was found that the antioxidant activity in the 50% honey dilution, the highest concentration we tested, was equivalent to a concentration of uric acid of 0.62 mM.

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Section: Discussionsupporting

confidence: 93%

Antioxidant Capacity of Venezuelan Honey in Wistar Rat Homogenates

Pérez

Rodrı́guez-Malaver

Vit

2006

Journal of Medicinal Food

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“…Due to its antioxidative effects, propolis may protect humans from deleterious oxidative processes. Several groups of authors thus studied the antioxidative properties of propolis and their active constituents [33][34][35] . Propolis may also act as a scavenger against oxygen radicals.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural view of colon anastomosis under propolis effect by transmission electron microscopy

Kılıçoğlu¹,

Kilicoglu²,

Erdemlı³

2008

WJG

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AIM:To evaluate the effect of propolis administration on the healing of colon anastomosis with light and transmission electron microscopes. METHODS: Forty-eight Wistar-Albino female rats were divided into two groups and had colon resection and anastomosis. In group Ⅰ, rats were fed with standard rat chow pre-and postoperatively. The rats in group Ⅱ were fed with standard rat chow and began receiving oral supplementation of propolis 100 mg/kg per day beginning 7 d before the operation and continued until they were sacrificed. Rats were sacrificed 1, 3, 7 and 14 d after operation, and anastomotic bursting pressures measured. After the resection of anastomotic segments, histopathological examination was performed with light and transmission electron microscopes by two blinded histologists and photographed. RESULTS: The colonic bursting pressures of the propolis group were statistically significantly better than the control group. Ultrastructural histopathological analysis of the colon anastomosis revealed that propolis accelerated the phases of the healing process and stimulated mature granulation tissue formation and collagen synthesis of fibroblasts. CONCLUSION: Bursting pressure measurements and ultra structural histopathological evaluation showed that administration of propolis accelerated the healing of colon anastomosis following surgical excision.

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“…This effect is probably due to the antioxidant protective effect of propolis which could have accumulated in the cells of the proximal convoluted tubules of the kidney where propolis was reported to be collected and secreted [156]. Osman and Tantaway [157] observed that oral administration of propolis extracts to rabbit significantly protected against histopathological alterations induced by gentamicin.…”

Section: Propolismentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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In Vivo Antioxidative Activity of Propolis Evaluated by the Interaction with Vitamins C and E and the Level of Lipid Hydroperoxides in Rats

Cited by 61 publications

References 34 publications

Antioxidant Capacity of Venezuelan Honey in Wistar Rat Homogenates

Antioxidant Capacity of Venezuelan Honey in Wistar Rat Homogenates

Ultrastructural view of colon anastomosis under propolis effect by transmission electron microscopy

Prevention of Nephropathy by Some Natural Sources of Antioxidants

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