In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydrazine derivatives of coumarin and chromone

Nawrot‐Modranka, Jolanta; Nawrot, Ewa; Graczyk, J

doi:10.1016/j.ejmech.2006.06.004

Cited by 180 publications

(38 citation statements)

References 31 publications

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“…The chromone backbone has also been used to discover and develop NCEs with anticancer potential. Accordingly, a number of chromone derivatives were screened toward a panel of cancer cell lines [188][189][190][191][192][193][194][195] . Some of the obtained results are herein have shown significant cytotoxic activity [196] ; ii) Heterocyclic-substituted chromone derivatives have been screened and 6chloro-2-(2-quinolyl) chromone (Fig.…”

Section: Anticancer Activitymentioning

confidence: 99%

Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

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The last few decades have provided stunning progresses in the understanding of physiopathology of several diseases. The remarkable progress in research fields, like genetics, immunology, neurobiology, among others, as well as the advent of more powerful tools, have made it possible to characterize, monitor, and understand far more of the basis of physiology and disease. However, for some diseases the treatment remains a problematic issue as the efforts performed so far were not translated into therapeutic solutions. Notwithstanding the steady increase in the total amount of FCUP

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Section: Anticancer Activitymentioning

confidence: 99%

Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

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“…They are associated with various biological activities viz. antiviral [2,3], antibacterial [4,5], antimicrobial [6], anticoagulant [7], anti-inflammatory [8,9], anticancer [10,11], anticonvulsant [12], antioxidant [13], antifungal [14,15], and anti-HIV [16]. They also possess the properties like inhibition of platelet aggregation [17] and inhibition of steroid 5α-reductase [18].…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Coumarin Derivatives

Ansary¹,

Taher²

2020

Phytochemicals in Human Health

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Coumarin derivatives have a myriad of applications in medical science, biomedical research, and many industrial branches. For this reason, many efforts are being dedicated to the development of novel and more practical methods for synthesizing these compounds. This chapter describes several methods of one-pot synthesis of coumarin derivatives, including von Pechmann condensation, Knoevenagel condensation, Baylis-Hillman reaction, Michael addition, Kostanecki reaction, vinyl phosphonium salt-mediated electrophilic reaction, and Heck-lactonization reaction. The methods are compared with each other, and the advantages and disadvantages of each of them are addressed.

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“…Chromone derivatives exhibited significant biological activities such as anticancer, antitumor , antiviral , antibiotic , antimicrobial , antifungal , antioxidant , plant growth inhibitors , and physiological activity . Polyfunctional pyridines are highly reactive intermediates that have been extensively used in heterocyclic synthesis .…”

Section: Introductionmentioning

confidence: 99%