1984
DOI: 10.1016/b978-0-08-033201-7.50010-4
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In Vivo Application of Isfets: Summary of Current Laboratory Research and Probable Future Clinical Detectors

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Cited by 26 publications
(18 citation statements)
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“…Consequently, response of the ISFETs toward acids and C02 will vary considerably depending on the extent of the water in the layer and on which membrane components are controlling the initial pH of this layer. For example, hydrolysis of membrane plasticizers (e.g., phthalates) could yield trace levels of phthalic acid in this layer which would tend to make the initial pH of this region acidic (e.g., perhaps pH [4][5][6]. Similarly, as silicone rubber membranes cure, they liberate acetic acid which could be retained within this layer.…”
Section: Discussionmentioning
confidence: 99%
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“…Consequently, response of the ISFETs toward acids and C02 will vary considerably depending on the extent of the water in the layer and on which membrane components are controlling the initial pH of this layer. For example, hydrolysis of membrane plasticizers (e.g., phthalates) could yield trace levels of phthalic acid in this layer which would tend to make the initial pH of this region acidic (e.g., perhaps pH [4][5][6]. Similarly, as silicone rubber membranes cure, they liberate acetic acid which could be retained within this layer.…”
Section: Discussionmentioning
confidence: 99%
“…Recent literature and conference reports (4,12,13) regarding the performance of potassium ISFETs for continuous in vivo measurements have been contradictory. Some reports suggest that such devices are stable (12) while others clearly suggested significant drift problems (13).…”
Section: Discussionmentioning
confidence: 99%
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“…Several approaches to the fabrication of multiple-analyte in vitro and in vivo sensors have been reported previously. Ion-selective field effect transistor (ISFET) devices have very small sensing areas, allowing a single miniaturized solid-state chip to be configured for simultaneous monitoring of several analytes (2,5). While the ISFET concept has generated considerable interest, fundamental problems regarding sensor encapsulation, drift, and interference from electrically neutral acidic sample species (e.g.…”
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confidence: 99%