In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits

Bakirel, Tiilay; Bakırel, Utku; Üstüner, Oya; Ülgen, Sinem; Yardibi, Hasret

doi:10.1016/j.jep.2007.10.039

Cited by 319 publications

(230 citation statements)

References 41 publications

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“…The damage of lipids, proteins, and nucleic acids by free radicals with the simultaneous decline of antioxidant defense mechanisms leads to cell and tissue damage. It may be contributed to the secondary complications in diabetes (Bakirel et al, 2008). It has been postulated that most effects of oxidative stress in diabetes mellitus are diminished upon supplementation with certain plant antioxidants such as vitamins C, E and non-nutrient antioxidants as polyphenolic compounds (Sun et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and <i>In vitro</i> antioxidant potentials of extracts of ten medicinal plants used for the treatment of diabetes mellitus in Sri Lanka

Attanayake¹,

Jayatilaka²,

Pathirana³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Over the last decade, extensive research work has focused on the potential health benefits of antioxidants while many medicinal plant extracts have been evaluated for their antioxidant profile. Medicinal plants selected for this study are widely used in traditional medicine for the treatment of diabetes mellitus in Sri Lanka some of which are recommended as dietary supplements to the existing therapies. The present study aimed at determining the total polyphenol contents and total antioxidant activities of aqueous extracts of 10 selected Sri Lankan medicinal plants by three in vitro methods; Materials and Methods: DPPH(2, 2-diphenyl-2-picrylhydrazyl), FRAP (ferric reducing power) and NO (nitric oxide) assays. The aqueous plant extracts were tested at the concentration of 0.05 g/mL. The total polyphenol content was determined according to the Folin-Ciocalteu method while the total antioxidant activity was evaluated by DPPH, FRAP and NO assays with L-ascorbic acid as reference compound. Results:The total polyphenol content of the plant extracts varied from 0.41 to 13.00 mg GAE (gallic acid equivalents) per gram dry weight. The antioxidant activities ranged in IC 50 of 36.89-101.27 µg/mL, IC 50 of 139.56-419.93 µg/mL, 0.12-8.98 µM for DPPH, NO, FRAP assays, respectively. A significant positive correlation was observed between total polyphenol content and antioxidant activities (P< 0.05). Conclusion: Phytochemical analysis revealed the presence of polyphenolic compounds, alkaloids and flavonoids in the plant materials which also possessed in vitro antioxidant potentials. Polyphenolic compounds contribute significantly to the total antioxidant capacities of medicinal plant extracts.

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Section: Introductionmentioning

confidence: 99%

Phytochemical screening and <i>In vitro</i> antioxidant potentials of extracts of ten medicinal plants used for the treatment of diabetes mellitus in Sri Lanka

Attanayake¹,

Jayatilaka²,

Pathirana³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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“…Reaction with these cell membrane constituents leads to lipid peroxidation. 43 Increased LPO impairs membrane function by decreasing membrane fluidity and changing the activity of membrane-bound enzymes and receptors. 43 More importantly, LSEO treatment protected against malathion-induced hepatic and renal oxidative stress.…”

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confidence: 99%

“…43 Increased LPO impairs membrane function by decreasing membrane fluidity and changing the activity of membrane-bound enzymes and receptors. 43 More importantly, LSEO treatment protected against malathion-induced hepatic and renal oxidative stress. These data fully corroborated all previously reported in vivo and in vitro antioxidant and anti-inflammatory properties of .…”

mentioning

confidence: 99%

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Selmi

Jallouli²,

Gharbi³

et al. 2015

Journal of Medicinal Food

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We aimed in the present study to investigate the hepato-and nephroprotective effects of Lavandula stoechas essential oils (LSEO) against malathion-induced oxidative stress in young male mice as well as the possible mechanism implicated in such protection. Animals were divided into eight groups of 12 each: Control, malathion (200 mg/kg b.w.); Various doses of LSEO (10, 30, and 50 mg/kg b.w.), malathion + various doses of LSEO. Malathion and LSEO were daily per orally (p.o.) administered by intragastric gavage during 30 days. We initially found that malathion treatment induced body weight gain decrease as well as a clear nephro-and hepatotoxicity as assessed by significant relative liver and kidney weight increase and related hemodynamic parameters deregulation. Malathion exposure of mice also induced a considerable perturbation of metabolic parameters. On the other hand, we showed that malathion administration was accompanied by an oxidative stress status assessed by an increase of malondialdehyde (MDA) and hydrogen peroxide (H2O2) levels as well as a depletion of sulfhydril group content (-SH) and antioxidant enzyme activities such as catalase (CAT) and glutathione peroxidase (GPx), total superoxide dismutase (SOD), Cu/Zn-SOD, Mn-SOD, and Fe-SOD in the kidney and liver. More importantly, LSEO treatment abolished all malathion-induced body gain loss, liver and kidney relative weight increase, hemodynamic and metabolic disorders, as well as hepatic and renal oxidative stress. In conclusion, our data suggest that LSEO exerted potential hepato-and nephroprotective effects against malathion-induced oxidative stress in mice. The beneficial effect of LSEO might be related, in part, to its antioxidant properties.

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“…Shagirtha et al (2011) observed cadmium causes oxidative stress, leading to an increase in oxidative stress biomarker, depletion of antioxidant enzymes and also disturbances in membranes structures. SOD and CAT must work collectively to achieve their purpose (Bakirel et al, 2008). SOD dis-mutation of superoxide anion into hydrogen peroxide and oxygen.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of methanol extract of Telfairia occidentalis Hook. and Amaranthus hybridus Linn. against cadmium induced oxidative stress in rats

2017

J App Pharm Sci

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Oxidative stress caused by cadmium in living systems leading to various clinical interpretations has been well documented. The study investigated if methanol extract of Telfairia occidentalis and Amaranthus hybridus could ameliorate the toxicity caused by cadmium. Administration of cadmium lead to an increase in lipid peroxidation marker MDA 0.42+018, 1.66+1.13 and reduced the concentration of enzymatic antioxidants SOD 10.22+2.13, 10.92+0.54, Catalase 22.82+14.74, 19.90+1.16 and GSH 18.02+0.49, 12.89+085 in liver and kidney of the rats. Result for liver function assay showed a significant increase in AST 24.00+3.31, ALT 60.40+10.85 and ALP 78.05+15.75 in the serum of rats administered cadmium without treatment. Total protein concentration was significantly higher in the vegetable treated group when compared to the group administered cadmium without treatment 3.72+041. Kidney function assay, creatinine and urea were significantly high in the rat administered cadmium without treatment when compared to the rats that received the vegetables. Phytochemical screening showed the presence of flavonoids, phenols, alkaloid in high concentration in the vegetables. In vitro antioxidant reflected high radical scavenging activity. From the result of this study, the vegetable showed robust ameliorative effect on cadmium induced toxicity which can be labelled to the rich antioxidant content of the vegetables and also the ability of the vegetable to promote phase 2 bio-transformation of xenobiotic.

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In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits

Cited by 319 publications

References 41 publications

Phytochemical screening and <i>In vitro</i> antioxidant potentials of extracts of ten medicinal plants used for the treatment of diabetes mellitus in Sri Lanka

Phytochemical screening and <i>In vitro</i> antioxidant potentials of extracts of ten medicinal plants used for the treatment of diabetes mellitus in Sri Lanka

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Ameliorative effect of methanol extract of Telfairia occidentalis Hook. and Amaranthus hybridus Linn. against cadmium induced oxidative stress in rats

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