In vivo biodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice

Guo, Mingchun; Xu, Xiao-lei; Yan, Xincheng; Wang, Shasha; Gao, Shang; Zhu, Song

doi:10.1016/j.jhazmat.2013.06.040

Cited by 64 publications

(43 citation statements)

References 43 publications

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“…20,21 Guo et al reported that intraperitoneal injection of SiO 2 NPs showed low toxicity with regard to histopathological changes and serum biochemical parameters, and that SiO 2 NPs did not induce oxidative stress in mice after 7 days of injection. 22 Another intraperitoneal injection study in mice indicated that exposure to colloidal SiO 2 NPs for a period of 4 weeks did not have any effect on immunological parameters, such as serum immunoglobulin G and immunoglobulin M levels, or splenic lymphocyte numbers. 23 In addition, when rats were exposed to SiO 2 NPs via intratracheal instillation, no influence on markers of oxidative stress, including superoxide dismutase, inducible nitric oxide synthase, and cyclo-oxygenase type 2 enzymes, was found at 24 hours, 7 days, or 30 days after instillation.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats

Kim¹,

Lee²,

Lee³

et al. 2014

IJN

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This study was undertaken to investigate the potential toxicity and establish the no observed adverse effect level (NOAEL) and target organ(s) of negatively charged colloidal silica particles of different sizes, ie, SiO 2 EN20(−) (20 nm) or SiO 2 EN100(−) 2(100 nm), administered by gavage in Sprague-Dawley rats. After verification of the physicochemical properties of the SiO 2 particles to be tested, a preliminary dose range-finding study and 90-day repeated dose study were conducted according to the Organisation for Economic Cooperation and Development test guideline. Based on the results of the 14-day dose range-finding study, a high dose was determined to be 2,000 mg/kg, and middle and low doses were set at 1,000 and 500 mg/kg, respectively. In the 90-day toxicity study, there were no animal deaths in relation to administration of SiO 2 particles of either size. In addition, no treatment-related clinical changes or histopathological findings were observed in any of the experimental groups. Moreover, no difference in toxic effects from chronic exposure to SiO 2 EN20(−) (20 nm) or SiO 2 EN100(−) (100 nm) was observed. The results of this study indicate that the NOAEL for SiO 2 EN20(−) and SiO 2 EN100(−) would most likely be 2,000 mg/kg, and no target organ was identified in rats of either sex.

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Section: Discussionmentioning

confidence: 99%

Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats

Kim¹,

Lee²,

Lee³

et al. 2014

IJN

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“…One involves tissue structure changes [34,35], apoptosis [36,37], and inflammation infiltration in main organs (kidney, spleen, lung, brain, and heart). Another one targets certain systems, whose structural specificities are liable to concentrate NPs.…”

Section: Systemic Assessmentmentioning

confidence: 99%

Toxicity assessment of nanoparticles in various systems and organs

Yang

Qin

Zeng

et al. 2017

Nanotechnology Reviews

183

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Abstract:In the past decades, much attention has been paid to toxicity assessment of nanoparticles prior to clinical and biological applications. While in vitro studies have been increasing constantly, in vivo studies of nanoparticles have not established a unified system until now. Predictive models and validated standard methods are imperative. This review summarizes the current progress in approaches assessing nanotoxicity in main systems, including the hepatic and renal, gastrointestinal, pulmonary, cardiovascular, nervous, and immune systems. Histopathological studies and specific functional examinations in each system are elucidated. Related injury mechanisms are also discussed.

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“…118,[127][128][129] However, there is still considerable uncertainty on this topic, namely because reported results are widely variable and often contradictory. Despite the controversy, there is a general consensus on the relation between SNP physicochemical properties and its biocompatibility.…”

Section: Impact On Biodistribution Biocompatibility and Cytotoxicitymentioning

confidence: 99%

The role of surface functionalization of silica nanoparticles for bioimaging

Gomes

Trindade

Tomé

2016

J. Innov. Opt. Health Sci.

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Among the several types of inorganic nanoparticles available, silica nanoparticles (SNP) have earned their relevance in biological applications namely, as bioimaging agents. In fact,°uorescent SNP (FSNP) have been explored in this¯eld as protective nanocarriers, overcoming some limitations presented by conventional organic dyes such as high photobleaching rates. A crucial aspect on the use of°uorescent SNP relates to their surface properties, since it determines the extent of interaction between nanoparticles and biological systems, namely in terms of colloidal stability in water, cellular recognition and internalization, tracking, biodistribution and specicity, among others. Therefore, it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces, making surface functionalization a relevant step in order to take full advantage of particle properties. The versatility of the surface chemistry on silica platforms, together with the intrinsic hydrophilicity and biocompatibility, make these systems suitable for bioimaging applications, such as those mentioned in this review.

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In vivo biodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice

Cited by 64 publications

References 43 publications

Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats

Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats

Toxicity assessment of nanoparticles in various systems and organs

The role of surface functionalization of silica nanoparticles for bioimaging

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In vivo biodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice

Cited by 64 publications

References 43 publications

Toxicity of colloidal silica nanoparticles administered orally for 90&nbsp;days in rats

Toxicity of colloidal silica nanoparticles administered orally for 90&nbsp;days in rats

Toxicity assessment of nanoparticles in various systems and organs

The role of surface functionalization of silica nanoparticles for bioimaging

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Product

Resources

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Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats

Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats