In vivo biomechanical behavior of the trapeziometacarpal joint in healthy and osteoarthritic subjects

D’Agostino, Priscilla; Dourthe, Benjamin; Kerkhof, Faes; Lenthe, G. Harry van; Stockmans, Filip; Vereecke, Evie

doi:10.1016/j.clinbiomech.2017.09.006

Cited by 22 publications

(28 citation statements)

References 44 publications

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“…Conversely, nonhuman great apes that do not habitually perform forceful pad‐to‐pad opposition load the most palmar aspect of the Mc1 base during flexion and so have higher RBV/TV values in this region. Proximity patterns of the TMc joint in humans support this interpretation as they demonstrate that the tip of the palmar beak is closer to the trapezium during adduction and during a pad‐to‐side grip than in abduction and during an abducted power grip (Figure ; D'Agostino, Dourthe, Kerkhof, Van Lenthe, & Stockmans, ).…”

Section: Discussionmentioning

confidence: 84%

“…The theoretical proximity of the Mc1 to PP1 in these grips is represented by coloring vertices by heat map with red being the closest, and blue being farthest, distance between the articular surfaces (middle). A similar, but measured, pair of proximity maps for the TMc in these grips, is displayed on the Mc1 base in proximal view, palmar aspect up, (bottom; adapted from D'Agostino, Dourthe, Kerkhof, Van Lenthe, & Stockmans, )…”

Section: Predictionsmentioning

confidence: 98%

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Trabecular variation in the first metacarpal and manipulation in hominids

Dunmore

Bardo

Skinner

et al. 2019

American J Phys Anthropol

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Objectives: The dexterity of fossil hominins is often inferred by assessing the comparative manual anatomy and behaviors of extant hominids, with a focus on the thumb. The aim of this study is to test whether trabecular structure is consistent with what is currently known about habitually loaded thumb postures across extant hominids.Materials and methods: We analyze first metacarpal (Mc1) subarticular trabecular architecture in humans (Homo sapiens, n = 10), bonobos (Pan paniscus, n = 10), chimpanzees (Pan troglodytes, n = 11), as well as for the first time, gorillas (Gorilla gorilla gorilla, n = 10) and orangutans (Pongo sp., n = 1, Pongo abelii, n = 3 and Pongo pygmaeus, n = 5). Using a combination of subarticular and whole-epiphysis approaches, we test for significant differences in relative trabecular bone volume (RBV/TV) and degree of anisotropy (DA) between species. Results: Humans have significantly greater RBV/TV on the radiopalmar aspects of both the proximal and distal Mc1 subarticular surfaces and greater DA throughout the Mc1 head than other hominids. Nonhuman great apes have greatest RBV/TV on the ulnar aspect of the Mc1 head and the palmar aspect of the Mc1 base. Gorillas possessed significantly lower DA in the Mc1 head than any other taxon in our sample.Discussion: These results are consistent with abduction of the thumb during forceful "pad-to-pad" precision grips in humans and, in nonhuman great apes, a habitually adducted thumb that is typically used in precision and power grips. This comparative context will help infer habitual manipulative and locomotor grips in fossil hominins. K E Y W O R D Sfirst metacarpal, grip, hominid, manipulation, trabeculae

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Section: Discussionmentioning

confidence: 84%

Section: Predictionsmentioning

confidence: 98%

Trabecular variation in the first metacarpal and manipulation in hominids

Dunmore

Bardo

Skinner

et al. 2019

American J Phys Anthropol

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“…Our finding that the cartilage layers of the MC1 and trapezium are significantly thinner on the volar side may help explain observed patterns of cartilage degeneration in TMC OA. Several studies have reported that contact occurs around the volar side when the thumb is in a neutral posture (Ateshian et al, 1995;D'Agostino et al, 2017;Dourthe et al, 2016;Halilaj et al, 2015), as well as during lateral pinch (Ateshian et al, 1995;D'Agostino et al, 2017;Dourthe et al, 2016;Goto et al, 2014;Kuo et al, 2014;Pellegrini et al, 1993), abduction Fig. 6.…”

Section: Discussionmentioning

confidence: 99%

“…For each sample (i.e. 16 MC1 and 16 trapezia), nine testing locations were manually selected across the TMC articular surface corresponding to nine anatomical sub-regions, as defined in previous reports (D'Agostino et al, 2017;Dourthe et al, 2016). Force-displacement behavior of the cartilage at each testing location (i.e.…”

Section: Cartilage Indentation Testingmentioning

confidence: 99%

“…The primary function of cartilage is to provide joints with a low-friction gliding surface which distributes loads and allows smooth joint motion (Buckwalter et al, 2005). However, when OA occurs, the cartilage progressively degenerates increasing the contact pressure and leading to adverse morphological changes (D'Agostino et al, 2017). The most common symptoms of OA are articular pain and progressive loss of normal joint function (Woolf and Pfleger, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of healthy trapeziometacarpal cartilage properties using indentation testing and contrast-enhanced computed tomography

Dourthe

Nickmanesh²,

Wilson

et al. 2019

Clinical Biomechanics

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Background: The trapeziometacarpal joint is a common site for osteoarthritis development in the hand. When osteoarthritis is present, it results in significant functional disabilities due to the broad range of activities performed by this joint. However, our understanding of osteoarthritis initiation and progression at this joint is limited because of the current lack of knowledge regarding the properties and structure of the corresponding cartilage layers. The objective of this study is to assess the morphological and mechanical properties of trapeziometacarpal cartilage via the combination of indentation testing and contrast-enhanced computed tomography. Such research may lead to the development of medical imaging-based approaches to measure cartilage properties in vivo. Methods: Intact first metacarpals and trapezia were extracted from 16 fresh-frozen human cadaver hands. For each specimen, load-displacement behavior was measured at 9 testing sites using a standardized indentation testing device to calculate the normal force and Young's modulus of the cartilage sub-regions. The specimens were then immersed in CA4+ contrast agent solution for 48 h and subsequently scanned with a resolution of 41 μm in a HR-pQCT scanner to measure cartilage thickness and attenuation. Finally, correlations between compressive Young's modulus and contrast-enhanced computed tomography attenuation of the cartilage were assessed. Findings: No significant difference was found in cartilage thickness between the trapezium and first metacarpal, but the comparison between articular regions showed thinner cartilage around the volar aspect of both the first metacarpal and the trapezium. The first metacarpal cartilage was stiffer than the trapezial cartilage. A significant positive correlation was observed between Young's modulus and mean contrast-enhanced CT attenuations in superficial and full-depth cartilage in both the first metacarpal and the trapezium cartilage. Interpretation: The quantitative measurements of trapeziometacarpal thickness and stiffness as well as a correlation between Young's modulus and contrast-enhanced computed tomography attenuation provides a method for the non-destructive in vivo assessment of cartilage properties, a greater understanding of thumb cartilage behavior, and a dataset for the development of more accurate computer models.

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The deep trabecular structure of first metacarpals in extant hominids

Dunmore

Bachmann

Synek

et al. 2023

American Journal of Biological Anthropology

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ObjectivesRecent studies have associated subarticular trabecular bone distribution in the extant hominid first metacarpal (Mc1) with observed thumb use, to infer fossil hominin thumb use. Here, we analyze the entire Mc1 to test for interspecific differences in: (1) the absolute volume of trabecular volume fraction, (2) the distribution of the deeper trabecular network, and (3) the distribution of trabeculae in the medullary cavity, especially beneath the Mc1 disto‐radial flange.Materials and MethodsTrabecular bone was imaged using micro‐computed tomography in a sample of Homo sapiens (n = 11), Pan paniscus (n = 10), Pan troglodytes (n = 11), Gorilla gorilla (n = 10) and Pongo sp., (n = 7). Using Canonical Holistic Morphometric Analysis (cHMA), we tested for interspecific differences in the trabecular bone volume fraction (BV/TV) and its relative distribution (rBV/TV) throughout the Mc1, including within the head, medullary cavity, and base.ResultsP. paniscus had the highest, and H. sapiens the lowest, BV/TV relative to other species. rBV/TV distribution statistically distinguished the radial concentrations and lack of medullary trabecular bone in the H. sapiens Mc1 from all other hominids. H. sapiens and, to a lesser extent, G. gorilla also had a significantly higher trabecular volume beneath the disto‐radial flange relative to other hominids.DiscussionThese results are consistent with differences in observed thumb use in these species and may also reflect systemic differences in bone volume fraction. The trabecular bone extension into the medullary cavity and concentrations beneath the disto‐radial flange may represent crucial biomechanical signals that will aid in the inference of fossil hominin thumb use.

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In vivo biomechanical behavior of the trapeziometacarpal joint in healthy and osteoarthritic subjects

Cited by 22 publications

References 44 publications

Trabecular variation in the first metacarpal and manipulation in hominids

Trabecular variation in the first metacarpal and manipulation in hominids

Assessment of healthy trapeziometacarpal cartilage properties using indentation testing and contrast-enhanced computed tomography

The deep trabecular structure of first metacarpals in extant hominids

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