In vivo biostability of a poly(carbonate-urea)urethane graft

Seifalian, Alexander M.; Salacinski, Henryk J.; Tiwari, Alok; Edwards, A. J.; Bowald, Staffan; Hamilton, George

doi:10.1016/s0142-9612(02)00608-7

Cited by 139 publications

(106 citation statements)

References 27 publications

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“…However, the availability of grafts is limited, especially for elderly donors who are more likely to suffer from cardiovascular disease. Polymeric scaffolds such as synthetic polytetrafluoroethylene (PTFE), polyglycolic acid (PGA), and polyurethane have been used with varying degrees of success in large diameter vessel implantation [Salacinski et al, 2001;Tiwari et al, 2002;Seifalian et al, 2003;Kannan et al, 2004;Lin et al, 2004;Vara et al, 2005;Torikai et al, 2008;Dahl et al, 2011]. Natural biopolymers, such as collagen and fibrin, support enhanced cellular functions but lack adequate mechanical strength for arterial implantation [Swartz et al, 2005;Yao et al, 2005Yao et al, , 2008Isenberg et al, 2006;Shaikh et al, 2008].…”

Section: Introductionmentioning

confidence: 99%

A Novel Ovine ex vivo Arteriovenous Shunt Model to Test Vascular Implantability

Peng

Schlaich²,

Row³

et al. 2011

Cells Tissues Organs

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The major objective of successful development of tissue-engineered vascular grafts is long-term in vivo patency. Optimization of matrix, cell source, surface modifications, and physical preconditioning are all elements of attaining a compatible, durable, and functional vascular construct. In vitro model systems are inadequate to test elements of thrombogenicity and vascular dynamic functional properties while in vivo implantation is complicated, labor-intensive, and cost-ineffective. We proposed an ex vivo ovine arteriovenous shunt model in which we can test the patency and physical properties of vascular grafts under physiologic conditions. The pressure, flow rate, and vascular diameter were monitored in real-time in order to evaluate the pulse wave velocity, augmentation index, and dynamic elastic modulus, all indicators of graft stiffness. Carotid arteries, jugular veins, and small intestinal submucosa-based grafts were tested. SIS grafts demonstrated physical properties between those of carotid arteries and jugular veins. Anticoagulation properties of grafts were assessed via scanning electron microscopy imaging, en face immunostaining, and histology. Luminal seeding with endothelial cells greatly decreased the attachment of thrombotic components. This model is also suture free, allowing for multiple samples to be stably processed within one animal. This tunable (pressure, flow, shear) ex vivo shunt model can be used to optimize the implantability and long-term patency of tissue-engineered vascular constructs.

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Section: Introductionmentioning

confidence: 99%

A Novel Ovine ex vivo Arteriovenous Shunt Model to Test Vascular Implantability

Peng

Schlaich²,

Row³

et al. 2011

Cells Tissues Organs

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“…POSS has a cagelike structure while PUC gives the material hydrolytic and oxidative stability in vitro (8,9). Due to the mechanical properties and a lack of degradation, this material might be ideal for developing synthetic heart valves and aortic stent-grafts (10,11).…”

Section: Nanocaged Poss-pcu Scaffoldsmentioning

confidence: 99%

What’s up in nanomedicine?

Salieb-Beugelaar¹

2013

European Journal of Nanomedicine

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“…A relatively new generation of polyurethanes used in medical devices are based on poly(carbonate-urethane)s (PCUs). According to in vitro and early in vivo studies, PCUs exhibit improved resistance to hydrolytic degradation and in vivo stress cracking compared to oligoester based medical grade polyurethanes [17][18][19][20][21][22][23][24]. Furthermore, according to the mechanism of hydrolytic degradation of PCUs [25], a decrease of pH is not observed, which leads to a much lower inflammation of the surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Assessment of aliphatic poly(ester-carbonate-urea-urethane)s potential as materials for biomedical application

et al. 2017

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Selected mechanical and biological properties of biodegradable elastomeric poly(ester-carbonate-urea-urethane)s (PECUUs) point towards their potential to be applied as scaffolds in tissue engineering. Here we explore their medical applicability taking into account their hemocompatibility and cytotoxicity. The influence of the ester monomer (derivatives of adipic and succinic acids), as well as diisocyanate type (IPDI and HDI) on the investigated PECUUs properties is presented. The presence of aliphatic diisocyanates, cyclic IPDI or linear HDI, governs the adhesion of Candida cells to these polymers offering the possibility to control the biofilm formation on their surface. In comparison to the linear form, cyclic diisocyanates with pentamethylene succinate or adipate fragments had two to three times lower biofilm mass formation on their surface. Reduced hemoglobin release from red blood cells observed during incubation of tested polymers with human erythrocytes suspension indicates their potential biocompatibility with human tissues. PECUUs were also able to support the growth of human keratinocytes HaCaT on their surface when coated with collagen. In effect, IPDI derivatives might possess a high potential for use in biomedical applications.

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In vivo biostability of a poly(carbonate-urea)urethane graft

Cited by 139 publications

References 27 publications

A Novel Ovine ex vivo Arteriovenous Shunt Model to Test Vascular Implantability

A Novel Ovine ex vivo Arteriovenous Shunt Model to Test Vascular Implantability

What’s up in nanomedicine?

Assessment of aliphatic poly(ester-carbonate-urea-urethane)s potential as materials for biomedical application

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