In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering

Ghorbani, Fariba; Moradi, Lida; Shadmehr, Mohammad Behgam; Bonakdar, Shahin; Droodinia, Atosa; Safshekan, Farzaneh

doi:10.1016/j.msec.2017.04.150

Cited by 56 publications

(47 citation statements)

References 32 publications

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“…9 Researchers built a variety of tracheal scaffolds based on PCL using 3D print such as patch, 10 ring, 11 hollow bellows 12 or hybrid. 8,13 Similar studies 14 and clinical reports 15,16 demonstrated good prospects for PTS reconstruction. However, the surface hydrophobicity of PCL greatly affects cell adhesion, which is taken into consideration here.…”

Section: Introductionsupporting

confidence: 57%

“…According to the individual design specifications, it processes the printing material layer by layer to build a bionic construction . Researchers built a variety of tracheal scaffolds based on PCL using 3D print such as patch, ring, hollow bellows or hybrid . Similar studies and clinical reports demonstrated good prospects for PTS reconstruction.…”

Section: Introductionmentioning

confidence: 99%

“…7 Recently, scholars have focused on absorbable biomaterials 4 ; polycaprolactone (PCL) has a slow rate of biodegradation in vivo, which can prevent problems caused by excessive degradation, such as postoperative tracheal softening, collapse and restenosis. 8 3D printing technology is based on the X, Y, and Z-based space and created with CT image or computer aided design (CAD). According to the individual design specifications, it processes the printing material layer by layer to build a bionic construction.…”

Section: Introductionmentioning

confidence: 99%

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Selection of the optimum 3D‐printed pore and the surface modification techniques for tissue engineering tracheal scaffold in vivo reconstruction

Pan

Zhong

Shan

et al. 2018

J Biomedical Materials Res

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The influences of pore sizes and surface modifications on biomechanical properties and biocompatibility (BC) of porous tracheal scaffolds (PTSs) fabricated by polycaprolactone (PCL) using 3D printing technology. The porous grafts were surface‐modified through hydrolysis, amination, and nanocrystallization treatment. The surface properties of the modified grafts were characterized by energy dispersive spectroscopy (EDS) and scanning electron microscopy (SEM). The materials were cocultured with bone marrow mesenchymal stem cells (BMSCs). The effect of different pore sizes and surface modifications on the cell proliferation behavior was evaluated by the cell counting kit‐8 (CCK‐8). Compared to native tracheas, the PTS has good biomechanical properties. A pore diameter of 200 μm is the optimum for cell adhesion, and the surface modifications successfully improved the cytotropism of the PTS. Allogeneic implantation confirmed that it largely retains its structural integrity in the host, and the immune rejection reaction of the PTS decreased significantly after the acute phase. Nano‐silicon dioxide (NSD)‐modified PTS is a promising material for tissue engineering tracheal reconstruction. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 360–370, 2019.

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Section: Introductionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Selection of the optimum 3D‐printed pore and the surface modification techniques for tissue engineering tracheal scaffold in vivo reconstruction

Pan

Zhong

Shan

et al. 2018

J Biomedical Materials Res

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“…The graft was seeded with adipose‐derived MSC and chondrocytes for 1 month and implanted in rabbit for the tracheal constructs. in vivo implantation confirmed biocompatibility and cell adhesion with mechanically rigid regenerated tissue (Ghorbani et al, ). Further, Wu et al () designed trilayer graft, which consists of electrospun poly(l‐lactide‐co‐ε‐caprolactone) (PLCL), PLGA + Silk, and collagen fibers, and seeded with human umbilical vein endothelial cell and smooth muscle cells.…”

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 78%

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

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Airway system is a vital part of the living being body. Trachea is the upper respiratory portion that connects nostril and lungs and has multiple functions such as breathing and entrapment of dust/pathogen particles. Tracheal reconstruction by artificial prosthesis, stents, and grafts are performed clinically for the repairing of damaged tissue. Although these (above-mentioned) methods repair the damaged parts, they have limited applicability like small area wounds and lack of functional tissue regeneration. Tissue engineering helps to overcome the abovementioned problems by modifying the traditional used stents and grafts, not only repair but also regenerate the damaged area to functional tissue. Bioengineered tracheal replacements are biocompatible, nontoxic, porous, and having 3D biomimetic ultrastructure with good mechanical strength, which results in faster and better tissue regeneration. Till date, the bioengineered tracheal replacements studies have been going on preclinical and clinical levels. Besides that, still many researchers are working at advance level to make extracellular matrix-based acellular, 3D printed, cell-seeded grafts including living cells to overcome the demand of tissue or organ and making the ready to use tracheal reconstructs for clinical application. Thus, in this review, we summarized the tracheal tissue engineering aspects and their outcomes. K E Y W O R D S biocompatible, chondrocytes, ECM, in vivo, tissue engineering, trachea

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“…Tissue engineering strategies 274 are not yet able to produce an ideal tracheal implant. Nonetheless, TE holds the potential to realize advanced and optimal tracheal grafts 29,275,276 while considering the following factors such as: With the passage of time, several progressions in tracheal tissue engineering have been made 271 .…”

Section: 7-tracheamentioning

confidence: 99%

Recent concepts in biodegradable polymers for tissue engineering paradigms: a critical review

Iqbal

Khan

Asif

et al. 2018

International Materials Reviews

153

114

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Tissue engineering and regenerative medicine are emerging as future approaches for the treatment of acute and chronic diseases. However, many challenging clinical conditions exist today and include congenital disorders, trauma, infection, inflammation and cancer, in which hard and soft tissue damage, organ failure and loss are still not treated effectively. Regenerative medicine has contributed to a number of innovations through artificial implants and biomedical materials, with advances are continually being made. Researchers are constantly developing new biomaterials and tissue engineered technologies to stimulate tissue regeneration in order to repair and replace damaged or malfunctioning organs. However, the challenge continues to lie in devising effective biomedical materials that can be implanted as scaffolds. Various approaches are emerging, according to the organ, tissue, disease and disorder. Scaffolds are implanted cell-free, or incorporated with stems cells, committed cells, or bioactive molecules. Irrespective, engineered biomaterials are required to regenerate and ultimately reproduce the original physiological, biological, chemical and mechanical properties over time. This is enabled by providing a three-dimensional architecture for cells to adhere, migrate, proliferate within, and differentiate appropriately for the growth of new tissues to provide a relevant structure, and in so doing, restore function. Biodegradable materials have been used extensively as regenerative therapies since their advent in early 20th century. One notable example is the development of surgical fixation devices. The selection, design and physicochemical properties of these materials are important and must consider biocompatibility, biodegradability and minimal cytotoxicity in the host to enable cell-proliferation, cell-matrix interactions and intercellular signalling for stimulating tissue growth. In this review, we critique the most studied and recently developed biodegradable

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In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering

Cited by 56 publications

References 32 publications

Selection of the optimum 3D‐printed pore and the surface modification techniques for tissue engineering tracheal scaffold in vivo reconstruction

Selection of the optimum 3D‐printed pore and the surface modification techniques for tissue engineering tracheal scaffold in vivo reconstruction

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Recent concepts in biodegradable polymers for tissue engineering paradigms: a critical review

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