In vivo complement activation by polyanion-polycation complexes: Evidence that C5a is generated intravascularly during heparin-protamine interaction

Fehr, Jörg; Rohr, H. P.

doi:10.1016/0090-1229(83)90002-8

Cited by 34 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The influence of complement activation on the adverse changes noted with protamine reversal of heparin's anticoagulant effect has been debated in the literature. [32][33][34][35][36][37][38] In the present study we did not find statistically significant differences between groups in total hemolytic complement, but C3a levels were elevated after protamine reversal ofheparin. Although the complement levels observed in our study reflected activation, most likely this activation reflects a response to protamine reversal, because the extent of complement elevation is not enough to account solely for the observed hemodynamic and hematologic effects.…”

Section: Discussionmentioning

confidence: 68%

Protamine pretreatment attenuation of hemodynamic and hematologic effects of heparin-protamine interaction

Wakefield¹,

Hantler²,

Lindblad³

et al. 1986

Journal of Vascular Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 68%

Protamine pretreatment attenuation of hemodynamic and hematologic effects of heparin-protamine interaction

Wakefield¹,

Hantler²,

Lindblad³

et al. 1986

Journal of Vascular Surgery

View full text Add to dashboard Cite

“…This ratio is largely dependent on the molecular weight and antithrombin III affinity. 25 Heparins are generally standardized in terms of pharmacologic activity as units per milligram. The methods used to determine the unitage of heparin, however, are of limited value in the potency standardization of heparin fractions and fragments.…”

Section: Fig 2 a Simplified Diagram To Illustrate Antithrombin III mentioning

confidence: 99%

“…10,85,86 This approach may alleviate the bleeding risk in patients treated with heparin. 9,10,25,30,48 The bioavailability of these fractions is far superior to that of conventional heparin and thus may prove to be more predictable and better antithrombotic agents. Also many of the byproducts of heparin manufacturing at this time are wasted.…”

Section: Fig 2 a Simplified Diagram To Illustrate Antithrombin III mentioning

confidence: 99%

Heparin, Its Fractions, Fragments and Derivatives Some Newer Perspectives

Fareed¹

1985

Semin Thromb Hemost

View full text Add to dashboard Cite

A brief attempt has been made to provide an overview of the field of heparinology. As stated, in coming years one should witness significant developments in this area. It is, however, important to caution that the newer products derived from heparin may not behave like heparin, and one must consider their individual molecular and biochemical interactions. The available limited data on heparin may or may not be applicable to the newer heparin fractions or derivatives. Independent preclinical and clinical trials are needed to investigate the pharmacology and therapeutic actions of newer heparin derivatives.

show abstract

“…Suffolk sheep weighing [25][26][27][28][29][30][31][32][33][34][35] kg were anesthetized by mask with 1-2% halothane (Halocarbon Laboratories, Hackensack, N.J.) in pure oxygen and surgically instrumented using sterile techniques. The right femoral artery was cannulated with a polyvinyl chloride catheter advanced to the midthoracic aorta to sample blood and monitor systemic blood pressure (Psa).…”

Section: Animal Preparationmentioning

confidence: 99%

Neutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep.

et al. 1990

View full text Add to dashboard Cite

Protamine reversal of heparin anticoagulation in patients is occasionally associated with life-threatening acute pulmonary hypertension. In a sheep model, we evaluated the effect on this adverse cardiopulmonary reaction of modifying the type of heparin (low molecular weight heparin compared with unfractionated heparin) and the type of heparin antagonist (polybrene compared with protamine). Protamine reversal of low molecular weight heparin (LMWI) and polybrene reversal of unfractionated heparin induced more than a 10-fold increase of plasma thromboxane B2 levels, a threefold increase of pulmonary vascular resistance and pulmonary artery pressure, and a 25% decrease of Pao2. A similar adverse reaction followed protamine reversal of conventional unfractionated heparin. However, with polybrene (1 mg/lkg) reversal of LMWH (1 mg/kg), we measured neither pulmonary hypertension (pulmonary artery pressure was 22.6±3.6 mm Hg at 1 minute after polybrene reversal of LMWH compared with 47.9±4.2 mm Hg after protamine reversal of unfractionated heparin, p

show abstract

In vivo complement activation by polyanion-polycation complexes: Evidence that C5a is generated intravascularly during heparin-protamine interaction

Cited by 34 publications

References 24 publications

Protamine pretreatment attenuation of hemodynamic and hematologic effects of heparin-protamine interaction

Protamine pretreatment attenuation of hemodynamic and hematologic effects of heparin-protamine interaction

Heparin, Its Fractions, Fragments and Derivatives Some Newer Perspectives

Neutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep.

Contact Info

Product

Resources

About