In Vivo Confocal Endomicroscopy in the Diagnosis and Evaluation of Celiac Disease

Leong, Rupert W.; Nguyen, Nam Q.; Meredith, Christopher; Al–Sohaily, Sam; Kukic, Darko; Delaney, Peter; Murr, Elise R.; Yong, Jim; Merrett, Neil D.; Biankin, Andrew V.

doi:10.1053/j.gastro.2008.08.054

Cited by 95 publications

(76 citation statements)

References 23 publications

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“…Confoc al endomic rosc opy (CEM) is a novel method that permits magnific ation in vivo of the gastrointestinal muc osa by up to 1000-fold. In persons with known CD, accuracy of CEM in diagnosing CD was reported to be exc ellent, with rec eiver operator c harac teristic s under the curve of 0.946, sensitivity of 94%, and specificity of 92% [64] . CEM was also sensitive in the detec tion of histologic al c hanges following treatment with a GFD.…”

Section: Mucosal Histologymentioning

confidence: 99%

Recent advances in celiac disease

Freeman

Chopra²,

Clandinin³

et al. 2011

WJG

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Celiac disease now affects about one person in a hundred in Europe and North America. In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease. This review will be of use to all internists, pediatricians and gastroenterologists.

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Section: Mucosal Histologymentioning

confidence: 99%

Recent advances in celiac disease

Freeman

Chopra²,

Clandinin³

et al. 2011

WJG

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“…Narrow-band imaging (NBI), which utilizes blue and green wavelengths of light for illumination, can be incorporated for contrast enhancement of vascular patterns on the mucosal surface (37). It is also possible to inspect multiple mucosal layers simultaneously for the presence of pathology, using confocal laser endomicroscopy, also known as visual biopsy (38). The scale invariance property of multi-scale and multi-orientation wavelet transforms can also be applied for texture recognition and classification of pathologic regions in VCE images acquired from untreated celiac disease patients (39).…”

Section: Videocapsule Quantitative Featuresmentioning

confidence: 99%

Coeliac disease and the videocapsule: what have we learned till now

et al. 2017

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Celiac disease is diagnosed in part by finding areas of pathology in the small bowel (SB) mucosa.This can often be difficult because the pathologic alterations, including atrophy of the small intestinal villi, can often be sparse and subtle. Some of the quantitative methods for detecting and measuring the presence of villous atrophy from videocapsule endoscopy (VCE) images are presented and discussed. These methods consist of static features of measurement including texture, gray level, and presence and abundance of fissures contained within each acquired image. The methods also consist of dynamic measurements including spectral analysis, and determining motion from a sequence of endoscopic images as obtained from a VCE clip. Thus far, several methods have been found useful to characterize the SB mucosa of untreated celiac disease patients versus control patients lacking villous atrophy, which have revealed significant differences in texture, frequency, and motion on analysis of VCE. In untreated celiac patients undergoing endoscopy, there tends to be greater magnitude of changes and spatial differences in textural descriptors, longer periodic components, indicating slower periodic activity, and differences in feature location, suggesting alterations in motility at areas of pathology as compared to patients without villous atrophy. Improvements in the quantitative analysis of VCE imaging in celiac patients is important to detect pathology in suspected patients, so that biopsies can be obtained from pertinent regions of the small intestinal mucosa. Improvements are also necessary so that patients with celiac disease can be monitored to evaluate the progress of mucosal healing after onset of treatment.

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“…A number of recently developed techniques have been found useful to enhance the endoscopic images of villous atrophy, including magnification endoscopy [10], with or without chromoendoscopy [11], immersion techniques [12], and confocal endoscopy [13][14][15][16]. However, some of these methods typically require sophisticated instrumentation, special training, and expertise.…”

Section: Enhancement Of Endoscopic Images By I-scan and Other Meansmentioning

confidence: 99%