In vivo coronary plaque histology in patients with stable and acute coronary syndromes

Pucci, Angela; Sheiban, Imad; Formato, L.; Celeste, Angela; Brscic, Elvis; Moretti, Claudio; Bernardi, Alberto De; Alberti, Alessandro; Bergamasco, Laura; Trevi, G. P.; Fuster, Valentín

doi:10.1016/j.atherosclerosis.2006.07.026

Cited by 20 publications

(16 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, we confirmed the clinical diagnosis of UA to be associated with higher atheroma content and lesser plaque collagenization, in keeping with previous studies [11,22,34].…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

C‐reactive protein and coronary composition in patients with percutaneous revascularization

Pucci

Brscic²,

Tessitore

et al. 2008

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…Finally, we confirmed the clinical diagnosis of UA to be associated with higher atheroma content and lesser plaque collagenization, in keeping with previous studies [11,22,34].…”

Section: Discussionsupporting

confidence: 92%

“…Results of histology and immunohistochemistry were planimetrically quantified using a computer‐based morphometry software (Image Pro Plus 4·5, Media Cybernetics), as described previously [11]. Total and segmental areas for each plaque component were quantified on trichrome stain.…”

Section: Methodsmentioning

confidence: 99%

C‐reactive protein and coronary composition in patients with percutaneous revascularization

Pucci

Brscic²,

Tessitore

et al. 2008

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…Accordingly to the AHA histological classification of atherosclerosis, most vulnerable plaques (87%) of the present study corresponded to type VI complicated lesions [2,3]. Conversely, intra-plaque b-GGT was inversely correlated with fibrosis and microcalcifications, commonly observed in stable plaques in either carotid or coronary arteries [10,12].…”

Section: Discussionmentioning

confidence: 45%

b-Gamma-glutamyltransferase activity in human vulnerable carotid plaques

Pucci¹,

Franzini

Matteucci

et al. 2014

Atherosclerosis

Self Cite

View full text Add to dashboard Cite

a b s t r a c tObjective: The atherosclerotic plaque that is vulnerable to rupture and to superimposed thrombosis is mainly represented by a thin-cap fibroatheroma with or without ulceration/thrombosis and inflammatory infiltrates. Total serum gamma-glutamyltransferase (GGT) activity is an independent predictor for cardiovascular events. Four GGT fractions have been identified in plasma and only one of them (b-GGT) in atherosclerotic plaques, but the possible role of GGT in plaque pathophysiology has not been assessed yet. We investigated the relationships between plaque b-GGT activity and the histological features of plaque vulnerability. Methods and results: Plaque GGT activity was investigated in 65 patients undergoing carotid endarterectomy; plaques were histologically characterized and immunostained for GGT. Intra-plaque total and fractional GGT activity was determined by a cost-effective test of molecular size exclusion chromatography, and compared with histological markers of plaque vulnerability. Plaque cholesterol content was also measured by chromatography. b-GGT was the only fraction detected within the atherosclerotic plaques and intra-plaque b-GGT activity correlated to plaque cholesterol content (r ¼ 0.667, P < 0.0001), plasma b-GGT and f-GGT fractions (r ¼ 0.249; r ¼ 0.298, both P < 0.05). Higher b-GGT activity was found in thin-cap fibroatheromas and it was associated to histological markers of vulnerable plaques, i.e., larger necrotic areas, greater macrophage infiltration and higher cholesterol content (P < 0.05). Conclusions: intra-plaque b-GGT activity correlates with the histological markers of vulnerable plaque and with plasma b-GGT in human carotid atherosclerosis; these data support the possible role of b-GGT in clinically significant atherosclerotic disease.

show abstract

“…While patients with prior hypercholesterolemia have greater atherosclerotic burden and inflammatory levels, these effects may be mitigated by the pleiotropic properties of preadmission statin therapy either directly through LDL-C reduction or via an indirect effect on vasomotor function, coagulation, or inflammatory modulation. 16 The fact that patients with prior hypercholesterolemia are more likely to be taking medications such as aspirin, clopidogrel, β-blockers, statins, and angiotensin-converting enzyme inhibitors prior to their ACS admission further supports this explanation; these medications may individually or synergistically contribute to the paradoxically lower risk of these diagnosed patients. While insurance status also correlates with health care use, the association between hypercholesterolemia and mortality that we observed persisted even after adjusting for insurance status and hospital factors.…”

Section: Discussionmentioning

confidence: 95%

Hypercholesterolemia Paradox in Relation to Mortality in Acute Coronary Syndrome

Wang

Newby

Chen

et al. 2009

Clinical Cardiology

View full text Add to dashboard Cite

show abstract

In vivo coronary plaque histology in patients with stable and acute coronary syndromes

Cited by 20 publications

References 30 publications

C‐reactive protein and coronary composition in patients with percutaneous revascularization

C‐reactive protein and coronary composition in patients with percutaneous revascularization

b-Gamma-glutamyltransferase activity in human vulnerable carotid plaques

Hypercholesterolemia Paradox in Relation to Mortality in Acute Coronary Syndrome

Contact Info

Product

Resources

About