In vivo covalent binding of cismethrin and bioresmethrin to hepatic proteins

Hoellinger, H.; Sonnier, Michelle; Pichon, J.; Lecorsier, A; Do-Cao-Thang,; Nguyen‐Hoang‐Nam,

doi:10.1016/0378-4274(83)90280-1

Cited by 7 publications

(1 citation statement)

References 11 publications

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“…It is possible that the trans-permethrin concentrations resulted from increased binding of trans-permethrin by hepatic or circulatory proteins, but literature reports suggest that covalent binding rates of pyrethroids by hepatic proteins are generally low. An in vivo study (Hoellinger et al, 1983) found that less than 6% of each of the type I pyrethroids cismethrin and bioresmethrin were covalently bound to rat liver proteins.…”

Section: Kineticsmentioning

confidence: 99%

Environmentally Relevant Mixtures in Cumulative Assessments: An Acute Study of Toxicokinetics and Effects on Motor Activity in Rats Exposed to a Mixture of Pyrethroids

Starr¹,

Scollon

Hughes³

et al. 2012

Toxicological Sciences

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Due to extensive use, human exposure to multiple pyrethroid insecticides occurs frequently. Studies of pyrethroid neurotoxicity suggest a common mode of toxicity and that pyrethroids should be considered cumulatively to model risk. The objective of this work was to use a pyrethroid mixture that reflects human exposure to common pyrethroids to develop comparative toxicokinetic profiles in rats, and then model the relationship between brain concentration and motor activity. Data from a national survey of child care centers were used to make a mixture reflecting proportions of the most prevalent pyrethroids: permethrin, cypermethrin, β-cyfluthrin, deltamethrin, and esfenvalerate. The mixture was administered orally at one of two concentrations (11.2 and 27.4 mg/kg) to adult male rats. At intervals from 1 to 24h, motor activity was assessed and the animals were sacrificed. Pyrethroid concentrations were measured in the blood, liver, fat, and brain. After controlling for dose, there were no differences in any tissue concentrations, except blood at the initial time point. Elimination half-lives for all pyrethroids in all tissues were < 7h. Brain concentrations of all pyrethroids (when cis- and trans-permethrin were pooled) at the initial time point were proportional to their relative doses. Decreases in motor activity indicated dose additivity, and the relationship between pyrethroid brain concentration and motor activity was described by a four-parameter sigmoidal E(max) model. This study links environmental data with toxicokinetic and neurobehavioral assays to support cumulative risk assessments of pyrethroid pesticides. The results support the additive model of pyrethroid effect on motor activity and suggest that variation in the neurotoxicity of individual pyrethroids is related to toxicodynamic rather than toxicokinetic differences.

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Section: Kineticsmentioning

confidence: 99%

Environmentally Relevant Mixtures in Cumulative Assessments: An Acute Study of Toxicokinetics and Effects on Motor Activity in Rats Exposed to a Mixture of Pyrethroids

Starr¹,

Scollon

Hughes³

et al. 2012

Toxicological Sciences

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Synthese des Metabolites de L'Insecticide Deltamethrine : Acides Phenoxy‐3 Benzoiques (carboxyle ¹⁴C), Alcools Phenoxy‐3 Benzyiques (hydroxyméthyle ¹⁴C)

Do-Cao-Thang

Nguyen‐Hoang‐Nam

Hoellinger

et al. 1985

Labelled Comp Radiopharmac

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Synthese Du Metabolite De l'Insecticide Deltamethrine: Alcool Hydroxy‐5 Phenoxy‐3 Benzylique Et De Son Derive Methoxy‐5 Deuteries Et Trities

Do-Cao-Thang

Nguyen‐Hoang‐Nam

Hoellinger

et al. 1988

Labelled Comp Radiopharmac

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L a b o r a t o i r e d e Chimie e t Biochimie P h a r m c o l o g i q u e s e t Toxicologiques -Unit6 Associee au CNRS en D6veloppement Concert6 avec 1'INSEW (UA-400), 65 rue d e s S a i n t s -P e r e s , 75270 PARIS Cedex 06, France. SUMMARY P a r t i a l h y d r o l y s i s of LiBH4 w i t h d e u t e r a t e d , t r i t i a t e d water i n THF s o l u t i o n provided a simple and cheap method for the p r e p a r a t i o n of d e u t e r a t e d , t r i t i a t e d a l c o h o l s by r e d u c t i o n of esters : (a-2H) a l c o h o l , 5-hydroxy 3-phenoxybenzyl a l c o h o l ( m e t a b o l i t e of d e l t a m e t h r i n , t h e p y r e t h r o i d i n s e c t i c i d e ) . and (a- 5-methoxy-3-phenoxybenzylKey Words : Deuterium, T r i t i u m , P y r e t h r o i d . D e l t a m e t h r i n , Phenoxybenzyl alcohol.

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In vivo covalent binding of cismethrin and bioresmethrin to hepatic proteins

Cited by 7 publications

References 11 publications

Environmentally Relevant Mixtures in Cumulative Assessments: An Acute Study of Toxicokinetics and Effects on Motor Activity in Rats Exposed to a Mixture of Pyrethroids

Environmentally Relevant Mixtures in Cumulative Assessments: An Acute Study of Toxicokinetics and Effects on Motor Activity in Rats Exposed to a Mixture of Pyrethroids

Synthese des Metabolites de L'Insecticide Deltamethrine : Acides Phenoxy‐3 Benzoiques (carboxyle ¹⁴C), Alcools Phenoxy‐3 Benzyiques (hydroxyméthyle ¹⁴C)

Synthese Du Metabolite De l'Insecticide Deltamethrine: Alcool Hydroxy‐5 Phenoxy‐3 Benzylique Et De Son Derive Methoxy‐5 Deuteries Et Trities

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In vivo covalent binding of cismethrin and bioresmethrin to hepatic proteins

Cited by 7 publications

References 11 publications

Environmentally Relevant Mixtures in Cumulative Assessments: An Acute Study of Toxicokinetics and Effects on Motor Activity in Rats Exposed to a Mixture of Pyrethroids

Environmentally Relevant Mixtures in Cumulative Assessments: An Acute Study of Toxicokinetics and Effects on Motor Activity in Rats Exposed to a Mixture of Pyrethroids

Synthese des Metabolites de L'Insecticide Deltamethrine : Acides Phenoxy‐3 Benzoiques (carboxyle 14C), Alcools Phenoxy‐3 Benzyiques (hydroxyméthyle 14C)

Synthese Du Metabolite De l'Insecticide Deltamethrine: Alcool Hydroxy‐5 Phenoxy‐3 Benzylique Et De Son Derive Methoxy‐5 Deuteries Et Trities

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Synthese des Metabolites de L'Insecticide Deltamethrine : Acides Phenoxy‐3 Benzoiques (carboxyle ¹⁴C), Alcools Phenoxy‐3 Benzyiques (hydroxyméthyle ¹⁴C)